In the conditions of application of enzyme preparations there is the possibility of inclusion into mixed fodders structure of such cheap fodder grains as rye. Determination of the optimal dose of introduction of the liquid enzymatic fodder additive (xylanase – 8800 units; phytase – 600 units; cellulose – 880 units; r-gluco – 4000 units; a- amylase – 200 units) and its influence on stores productivity during the completion of growing and fattening periods was realized in the conditions of the Republic of Belarus. Research results showed the following: inclusion into mixed fodders of the increased amount of rye grain (without the enzyme additive) for stores feeding during the completion of growing (20%) and fattening (30%) periods did not render negative influence on experimental animals; the optimal dose of the trial enzyme for stores during the completion of growing period - (SK-21 including rye grain - 20%) was 200 ml per 1 t of mixed fodders; the optimal dose of the trial enzyme for stores during the fattening period (KDS-26 including rye -30%) was 150 ml per 1 t of mixed fodders. Application of the experimental fodder additive promoted the increasing live weight gain. There was noted the tendency of the positive influence of the analyzed enzyme on dry and organic matter, fat, dietary fibre and nitrogen-free extractive substances digestibility

In process of animal husbandry intensification much attention should be given to maintenance of the high-grade balanced feed of animals. Forage supplement Profat (Protected Fat) is a protected fat in dry-sand mould with 84% of fat content. Application of 0,5-0,8 kg of dry fat supplement in cows diets per 1 head a day (4,7-10,0% in mixed forage content) promotes the increasing of prime cost of milk yield with basic fatness at 1,8-2,8% within fatness growth at 0,1-0,24% without protein content decrease. During the analysis of morphological and biochemical blood structure there was not established any considerable inter-group distinctions. At the same time, it is necessary to notice, that in blood of animals of two experimental groups there was stated a little bit higher protein content. However, in proportion to application of experimental fat additive up to 0,8 kg per head a day the protein content decreased. The increased number of erythrocytes and hemoglobin content in blood of animal of trial groups proved the strengthening of metabolic processes. In blood of trial groups it was noted high quantity of vitamin A and phosphorus as well as lower amount of calcium

The purpose of research is to study influence of fodder additive Water Trit liquid on dynamics of live weight, natural resistance and determination of an optimal dose for pigs on growing. Thanks to рН decrease of intestines contents and presence of organic acids the additive is applied for disease prevention. Presence of organic acids stimulates the development of useful Lactobacillus micro flora in intestines gleam. From the received data positive influence of the fodder additive on a gain of body weight is visible. In the beginning of experiment the difference in body weight of a control and a trial groups was insignificant and made from 9,2 kg to 9,4 kg in the experimental group, and 9,3 kg - in the control group. In the end of experiment the difference in body weight was essential: 28,6 kg, 30,5 kg, 29,5 kg in the trial groups and 28,05 kg in the control. After application of the fodder additive Water Trit liquid in the trial groups there were noted the raised daily average weight gains: on 2,6% in the second, on 13,4% (P less than 0,05) - in the third and on 8,5% - in the fourth group in relation to control group. For studying of the influence of the fodder additive on animal organism there was carried out the blood testing: phagocytosis, bactericidal activity of blood serum, lysozyme activity of blood serum. Indexes on phagocytal index at animal of the control and trial groups were in the beginning of experiment approximately at one level. At 45-day age the indexes in the second and fourth trial groups were above the control ones on 5,2% and 8,9%, respectively. By the end of the experiment the phagocytal index in all four groups changed insignificantly. At studying of lysozyme activity of blood serum at pigs the given research have shown, that at 30-day age the indexes in the third and fourth trial groups were above the control, and indexes in the first group were above the standard of the control. At 70-day age the highest lysozyme activity of blood serum was in the second trial group and has made +16,0% to the control. It is necessary to notice, that on the 70th day this indicator was above the control in all three trial groups

There was studied the data on antagonistic activity of a new metabolic probiotic substance derived from the probiotic substance Diamixan. Research of antagonistic activity Diamixan has shown its high activity in the relation of the test-strains of microorganisms: Staphylococcus aureus ATSS 6538, Staphylococcus aureus 209R, Escherichia coli ATSS 71229, Pseudomonas aeruginosa ATSS 9017, Pseudomonas marcescens, Proteus mirabilis ATSS 14153, Bacillus subtilis ATSS 6633, Citrobacter freundii, Candida albicans ATSS 10231, Salmonella enteritidis R1991, Salmonella typhimurium ATSS 24853. In the presence of the preparation, dissolved 1:1, there was a full suppression of growth of all bacteria within 48 hours of cultivation at delution 1:2 and 1:4 the high antagonistic activity of the preparation as the majority of samples remains sterile remained. In the tabular form data on antagonistic activity of the preparation in delution 1:1; 1:2; 1:4 are presented. | Целью работы явилось изучение антагонистической активности метаболитного пробиотика диамиксан. Исследование антагонистической активности диамиксана показало его высокую активность в отношении тест-штаммов микроорганизмов: Staphylococcus aureus АТСС 6538, Staphylococcus aureus 209Р, Escherichia coli ATCC 71229, Pseudomonas aeruginosa ATCC 9017, Pseudomonas marcescens, Proteus mirabilis ATCC 14153, Bacillus subtilis ATCC 6633, Citrobacter freundii, Candida albicans ATCC 10231, Salmonella enteritidis P1991, Salmonella typhimurium ATCC 24853. В присутствии разведённого 1:1 препарата происходило полное подавление роста всех бактерий в течение 48 часов культивирования, при разведении 1:2 и 1:4 сохранялась высокая антагонистическая активность препарата, так как большинство образцов оставалось стерильными. В табличной форме представлены данные по антагонистической активности препарата в разведении 1:1; 1:2; 1:4.

In the conditions of the Republic of Belarus there was studied the activity of hepatic specific enzymes of blood serum of bull calves of black-and-white breed in course of application of various doses of zinc-containing preparations. Application of zinc-containing preparations led to multidirectional change of activity of hepatic specific serum enzymes. Application of Zinkovet preparation in dose of 1,8 g/100 kg of live weight made it possible to essentially grade the indexes of hepatic tissue affect. In the experimental group at animals there was marked the lowering in activity alanine-aminotransferase, serum glutamic oxalacetic transaminase and gamma-glutamyl transpeptidase. At the same time, there was noted the increasing of zinc-containing enzymes activity (sorbitol dehydrogenase and glutamate dehydrogenase). All these processes were caused by zinc inclusion into the metabolic process.

Influence of various levels of the organic form of selenium of Sel-Pleks on the formation of reproductive function of breeding bull-calves is studied in the conditions of the Republic of Belarus. Feeding of organic selenium to bull-calves promoted volume increase of ejaculate on 5,0%, quantities of male germ cells in ejaculate - on 9,1% and concentration of male germ cells in ejaculate - on 7,5% in comparison with animals in which rations sodium selenit was used. Application in winter period of the premix with inclusion of selenium in a dose of 0,4 mg per 1 kg of a dry matter of a ration allows to increase the quantity and quality of sperm of bull-calves: volume ejaculate - on 9,5%, concentration of male germ cells in ejaculate - on 16,4% (Р less than 0,05) and activity of male germ cells - on 8,9% (Р less than 0,001). Increasing of a dose of selenium up to 0,4 mg per 1 kg of a dry matter in rations of bull-calves in summer period allows to increase quantity and quality of sperm. At bull-calves of the third experimental group the ejaculate volume has increased on 4,5%, concentration of male germ cells in ejaculate - on 15,7% (Р0,05) and activity of male germ cells - on 7,3% (Р less than 0,001).

In the conditions of the Republic of Belarus there was studied the influence of various doses of kizelgur on metabolic processes and natural resistance of poultry by an example of lying hens. Use of the mineral additive rendered the positive influence on protein, carbohydrate, lipidic and mineral metabolism in hens. It was marked that in blood the content there was an increasing of crude protein on 11,5-11,7% (Р less than 0,05), crude lipids - on 1,9-5,3%, glucose - on 25,1-54,6% (Р less than 0,01), calcium - on 0,8-12,4%, phosphorus - on 8,9-15,9%, iron - on 9,2-24,6% (Р less than 0,01) and magnesium - on 9,3-21,6%. The laying hens which were fed with the mineral kizelgur additive were characterized by better resistance reactions. Bactericidal activity of blood serum of the experimental hens was higher on 2,7-15,3% (Р less than 0,01), lysozymic activity - on 1,3 22,5% (Р less than 0,05).

In the conditions of the Republic of Belarus there was studied the veterinary and sanitary quality and safety of poultry slaughter products after application of a natural biological corrector VitoLAD produced in Belarus on the basis of cultivation of nonpathogenic strain of fungi Fusarium sambuninum MKF-2001-3 used for restoration of dysfunction disorders. As a result of the realized bacteriological research there were marked no pathogenic and opportunistic organisms in all experimental samples of meat and internal organs. Indices of biological value of meat of three experimental and control group had no authentic differences. Displays of toxicity for infusorians were not marked. Poultry meat of investigated samples in control, and all three experimental groups (doses of 0,25 ml/head - the second experimental group, a dose of 0,5 ml/head - the third experimental group and a dose of 1 ml/head - the fourth experimental group) in diets of which there was added the natural biological corrector VitoLAD, proved to be good-quality and harmless. In accordance with organoleptic, physical and chemical, bacteriological indexes, as well as biological value and harmlessness did not concede to meat of the control group. The complex veterinary and sanitary estimation of bird carcasses of three experimental and control groups did not show any deviations from existing standards that made it possible to organize production realization without restriction.

In the conditions of the Republic of Belarus there were studied the productive and interior indexes of bull calves which were fed with dried distiller's grains. Inclusion into bull calves diets of the mixed fodder containing 33% of dried distiller's grains made it possible to increase the concentration of volatile fatty acids on 16-18%, albuminous nitrogen - on 4-7%, quantity of infusorians - on 16-17%, as well as to reduce the ammonia level in a ruminal liquid from 23,4 up to 17 mg%. Inclusion of 33% of dried distiller's grains into structure of mixed fodder and feeding the same quantity of fresh distiller's grains promoted increasing of nutrient digestibility on respectively 4,0-5,9% and 3,5-4,5%, nitrogen retention - on 13%. Increasing of level of dried distiller's grains in structure of grain forage up to 67% increased the digestibility of nutrients on 1,5-2% and nitrogen retention - on 4%. Substitution in mixed fodder for bull-calves of 33 and 67% of fodder grain by dried distiller's grains made it possible to increase daily average live weight gain of animals respectively on 10 and 4%. Feeding of dried and fresh distiller's grains at simultaneous introduction in rations of complex mineral additive promoted the activation of metabolic processes that was proved by increasing of crude protein of blood at 6-7% and 5-8%, as well as decreasing of concentration of urea - on 25 and 22% respectively. Use of 33% of dried distiller's grains as a part of mixed fodder for cattle young stock proved to be economically effective and allowed to lower the cost price of a live weight gain on 10-11%. Feeding with fresh distiller's grains allowed to lower the prime cost price on 7% and to receive additional profit.

In the conditions of the Republic of Belarus there was analyzed the efficiency of application of an adsorbent mycotoxins Toxfin Dry (Belgium) for lowering of toxicity load on broiler chickens. In the course of the study there was given attention to poultry productivity, viability and forage expenses for broiler chickens breeding. There was developed a scheme of Toxfin Dry preparation feeding to broiler chickens. There were presented the results of weighing of control and experimental broiler chickens during the breeding periods; the basic zootechnical indices in the conditions of introduction Toxfin Dry; economic efficiency of its application. Research results showed that introduction of a mycotoxin adsorbent Toxfin Dry into diets of broiler chickens promoted the improvement of digestion and absorption of mixed fodder nutrients in a gastroenteric tract, that in its turn promoted the increasing daily average weight gain on 4,3%, broiler stock viability - on 2,6%; and to decrease the expenses for forages on 13,9%. On the basis of obtained experimental data it was recommended to include the mycotoxin adsorbent Toxfin Dry into rations of broiler chickens as a dry mix with mixed fodder in a dose of 5 g/kg of forage dry matter.