An effort to demonstrate the mechanism of homeostatic alteration of high-producing cows at the period of increasing milking capacity and peculiar features of its changing in the conditions of introduction into cattle diets of carbohydrate containing and carbohydrate compensative additives was realized in the conditions of the Republic of Belarus. In course of the experiment there were used white-and-black breed cows of 3-4 lactations with body weight of 700 kg and milk yield over the last lactation of 7000-8000 kg of milk. Experimental cows in two weeks before the supposed calving were administrated with 50 ml of propylene glycol, 6 g of niacin and 50 ml of glycerin; and in course of 60 days after calving the administration of the additives was realized in doses of 125 ml; 6 g; 50 ml, respectively. Research results showed that application of mentioned above additives rendered the positive effect on cow liver that was proved by the improved hemic function of experimental cows: increasing of quantity of erythrocytes, hemoglobin, and hematocrit

Evaluation of efficiency of chelate forms of trace elements in rations of pregnant sows as a factor of improvement of their production indices and quality of obtained litter. It was determined that introduction into pregnant sows rations of chelate forms of zinc and iron starting from the 84th day of pregnancy and till farrowing led to authentic increasing of milk yield, weight of a litter at birth and at weaning periods, to increasing of live weight of obtained litter, and also proved to be a form of hypothrophics prevention in piglets.

Determination of the influence of new premixes on sperm quality and natural resistance of sire bulls during winter and summer periods was realized in the conditions of the republic of Belarus. Application of the developed vitamin and mineral additive in rations of sire bulls in course of winter and summer periods made it possible to increase their natural resistance, that was proved by the 7,2-8,8% increasing of the bactericidal activity of blood serum indicators, 0,6% increasing of lysozymic activity of blood serum, and 3,3-5,1% increasing of the phagocytic ability of leukocytes. There was determined the possibility to increase sire bull sperm quality during different year periods by means of application of the enhanced doses of vitamins and trace elements. As a result, the ejaculate volume increased on 7,4-2,4%, concentration of male germ cells in ejaculate on - 6,3-7,8%, sperm activity - on 6,7-7,3%, and also there was stated the decrease of spoilage percent of sperm production. Results of the industrial testing have confirmed efficiency of use of the recommended vitamin and mineral additive and calculated on its basis premixes. Its application made it possible to increase the quality of bull of sperm production on 3,6-10,8%

Development of diarrheal diseases of newborn animals has a miltifactorial character and it is very difficult to optimize the structure of microbial population in alimentary tract and to carry out the correction of the microbe status only by means medical preparations. Therefore, for regulation of standard structure of intestine microflora in a complex of medical and preventive measures for diarrhea diseases of young poultry an important role is played by application of probiotics, prebiotics, and immunoamplifiers. In course of study there were used biologically active preparations produced on the basis of ecologically pure products of a natural origin: immunostimulant Alveozan, probiotics Bifidoflorin liquid and Dialakt, and prebiotics Biofon АIL and Biofon. Research was realized on one-day-old broiler chickens of Kobb-500 cross. The obtained data on the positive influence of the studied preparations on microbiocenosis of an alimentary tract of broilers chickens correlated with the indexes of natural resistance (autarcesis).The analyzed preparations made it possible to increase the local protection, stimulation of hematopoiesis (increasing of hematoglobulin, erythrocytes and leukocytes); to increase the blood content of whole protein, albumens and globulins, bactericidal activity of blood serum. Complex introduction of the analysed preparations stimulated the natural disease resistance factors, normalized the metabolic function of poultry, promoted the increasing of chicken livability and productivity

In conditions of the Republic of Belarus much attention is given to optimization of energy and protein content in diets of dry cows. Analysis of the influence of different energy and protein ratio in dry cows diets on their productivity was realized. Increasing of protein and energy balance standards of dry cows during the winter period on 10 and 15% at the expense of introduction of protein, vitamin and mineral supplements (PVMS) made it possible to increase the daily average weight gain of animals on 5,4% and 12,2%, live weight of calves at a birth on 3,6% and 8,1% and their daily average weight gain over the first month - on 3,9% and 12,1%, respectively. Feeding with PVMS produced on the basis of peas and rape made it possible to raise the digestibility of nutritive substance on 1,4-14% and accessibility of all mineral substances on 0,4-10%. The increasing of energy and protein ratio on 15% in diets of pregnant dry cows rendered the positive effect on dairy efficiency. Fodder expenses for fodder unit production decreased on 5,5 and 6,8%, respectively. Inclusion of PVMS in mixture with pea and rape flour for dry pregnant cows during the summer period made it possible to raise their live weight on 5,9% and 9,7%, weight of calves at birth on 4,2% and 7,3%, and their daily average weight gain - on 5,7 and 9,4%. Optimization of power and protein fodder of pregnant dry cows promotes the increasing of milk yields in the first 100 days of the subsequent lactation on 5,1% and 9,9% and the decreasing of forage expenses for production unit on 4,6-9,1%

Analysis of supply of first-calf heifer diets with the mineral substances and their blood level at the first period of lactation as well as the development of the optimal feed formula of the mineral premix which could make it possible to neutralize the possible deficit of nutritive elements was realized in the conditions of the Republic of Belarus. It was stated that in animal diets against the background of protein and carbon misbalance there was noted the deficit of a number of trace elements such as manganese, copper, cobalt and zinc. In spite of sufficient content of calcium and phosphorus in cow diets, their concentration in blood plasma in first-calf heifers did not correspond to standard criteria, that was probably caused by vitamin D deficiency in cow rations. There was marked a low level of zinc, cobalt and manganese in whole blood of the majority of cows. With the purpose of correction of the first-calf heifer rations and for the prevention of possible hypomicroelementoses there was developed the composition of premix taking into account the necessary of cow feeding standards

Studying of influence of various levels of selenium on growth, protein structure of blood serum, natural resistance, and reproductive performance of pedigree bull-calves was realized in the conditions of the Republic of Belarus. It was established, that feeding with an optimum dose of selenium (0,4 mg per 1 kg of dry matter) in rations of replacement bull-calves during the raising period promoted the increasing of daily average weight gain on 6,8%, indexes of natural resistance - on 0,5-13,9%, and sperm production quality - on 4,5-27,3%. In the conditions of optimization of selenium level of in diets the protein structure of blood serum of replacement bull-calves exceeded the similar index at control animals by the crude protein index - on 8,3 (Р less than 0,05), by albumine and alpha globulin -on 2,2% and 1,6%, respectively. Application of selenium in dose of 0,4 mg per 1 kg of dry matter made it possible to increase the indexes of natural resistance on 0,5-13,9%. Increase of selenium dose up to 0,4 mg per 1 kg of dry matter in made it possible to increase the quantity and quality of sperm of bull-calves, that was proved by the increasing of ejaculate volume on 4,5%, concentration of male germ cells in ejaculate – on 15,7% (Р less than 0,05) and male germ cells activity - on 7,3% (Р less than 0,001)

Research on studying of probiotics and prebiotics influence on natural resistance, hemogenesis, metabolism, growth, development and safety are spent on chickens of 1-37-day age in the conditions of clinic of the department of internal noncontagious diseases and the central resarch laboratory of research institute of applied veterinary medicine and biotechnology Vitebsk State Academy of Veterinary Medicine. It was established that the combined use of probiotics and prebiotics increases the defense, raises safety rate and stimulates body weight gain in broiler chickens. Hence, probiotics and prebiotics at joint application render expressed growth-promoting effect, promote high safety of young growth, disease decrease, increase in a weight gain, raise indicators of the general and local protection, stimulate hemogenesis and exchange processes during the most intense periods of bird cultivation. At separate application of probiotics and prebiotics these indicators were a little lower, but authentically above, than at chickens of control group | Исследования по изучению влияния пробиотиков и пребиотиков на естественную резистентность, гемопоэз, обмен веществ, рост, развитие и сохранность, проведены на цыплятах 1-37-дневного возраста в условиях клиники кафедры внутренних незаразных болезней и центральной научно-исследовательской лаборатории Научно-исследовательского института прикладной ветеринарной медицины и биотехнологии УО ВГАВМ. Совместное применение пробиотика и пребиотика усиливает защиту, повышает сохранность и стимулирует прирост массы тела цыплят-бройлеров. Следовательно, про пробиотики и пребиотики при совместном применении оказывают выраженное ростостимулирующее действие, способствуют высокой сохранности молодняка, снижению заболеваемости, увеличению прироста массы, повышают показатели общей и местной защиты, стимулируют гемопоэз и обменные процессы в наиболее напряженные периоды выращивания птицы. При раздельном применении пробиотиков и пребиотиков эти показатели были несколько ниже, но достоверно выше, чем у цыплят контрольной группы

There was developed a method of increasing the efficiency of used feeds and poultry productivity by means of stimulations of natural resistance of an organism by biologically active substances (Vigozin preparation, containing carnitine). Application of preparation Vigozin with potable water twice in a dose of 1 ml on 1 l of water within first 3 days and for 13th day of cultivation allows to raise safety of chickens-broilers on 2,3% at the expense of normalization of metabolism at young growth and preservation of a functional condition of a liver. Results of the general clinical and the immunological analysis of blood at chickens-broilers of control and trial groups (M+/-m, n=10), biochemical indicators of blood at chickens-broilers of control and trial groups in age dynamics (M+/-m, n=10) are presented. | Целью работы являлось научное обоснование и разработка способа повышения эффективности использования кормов и продуктивности птицы путем стимуляции естественной резистентности организма биологически активными веществами (препарат Вигозин, содержащий карнитин). Применение препарата Вигозин с питьевой водой двукратно в дозе 1 мл на 1 л воды в течение первых 3-х суток и на 13-й день выращивания позволяет повысить сохранность цыплят-бройлеров на 2,3% за счет нормализации обмена веществ у молодняка и сохранения функционального состояния печени. Представлены результаты общего клинического и иммунологического анализа крови у цыплят-бройлеров контрольной и опытной групп (M+/-m, n=10), биохимические показатели крови у цыплят-бройлеров контрольной и опытной групп в возрастной динамике (M +/- m, n=10).