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Indocyanine green disposition in healthy dogs and dogs with mild, moderate, or severe dimethylnitrosamine-induced hepatic disease.
1992
Boothe D.M. | Brown S.A. | Jenkins W.L. | Green R.A. | Cullen J.M. | Corrier D.E.
Disposition kinetics of indocyanine green (ICG) were used to evaluate hepatic function in healthy Beagles (group 1; n = 6) and Beagles with progressive hepatic disease induced by oral administration of dimethylnitrosamine, a hepatospecific toxin. Three classes of hepatic disease were defined by histologic features: mild (group 2; n = 5), moderate (group 3; n = 6), and severe (group 4; n = 5). Disposition of ICG was studied 3 weeks following the last dose of toxin. A rapid IV injection of 0.5 mg of ICG/kg was administered and serum samples were obtained at certain intervals during 60-minute periods. Serum ICG was analyzed by use of visible spectrophotometry. Disposition kinetics were determined from serum ICG concentrations vs 15- and 60-minute time curves and compared between one another and among groups. Data based on 60-minute time curves were not significantly different from those based on 15-minute curves. Area under the curve for ICG was greatest in group 3. Clearance of ICG was decreased and mean resident time was increased in groups 3 and 4, compared with those in groups 1 and 2. When disposition data (60 minutes) were normalized for differences in hepatic weight among dogs, group-3 mean resident time was significantly greater than that of group 4. This study supports the diagnostic benefits of using ICG disposition kinetics as a method of evaluating hepatic function in dogs with progressive liver disease.
Show more [+] Less [-]Ultrastructure of virus particles in the liver of piglets infected with porcine enterovirus serotype 3.
1992
Shin T.K | Lee C.S. | Huh M.D.
A pathological observation on the experimental rabbit viral hepatitis
1992
Jyeong, J.S. (Kyungpook Animal Health Experimental Inst., Taegu (Korea Republic). ) | Kwon, Y.R. | Lee, C.S. (Kyungpook Nat'l Univ., Taegu (Korea Republic). Coll. of Veterinary Medicine) | Shin, T.K. (Cheju Nat'l Univ., Cheju (Korea Republic). Dept. of Veterinary Medicine)
The effect of caffeine on promotion step of dimethylnitrosamine-initiated hepatic altered foci in a mid-term induction system
1992
Kim, S.H. (Korea Atomic Energy Research Inst., Seoul (Korea Republic). Korea Cancer Center Hospital) | Lee, C.S. (Kyungpook Nat'l Univ., Taegu (Korea Republic). Coll. of Veterinary Medicine)
