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Indocyanine green disposition in healthy dogs and dogs with mild, moderate, or severe dimethylnitrosamine-induced hepatic disease.
1992
Boothe D.M. | Brown S.A. | Jenkins W.L. | Green R.A. | Cullen J.M. | Corrier D.E.
Disposition kinetics of indocyanine green (ICG) were used to evaluate hepatic function in healthy Beagles (group 1; n = 6) and Beagles with progressive hepatic disease induced by oral administration of dimethylnitrosamine, a hepatospecific toxin. Three classes of hepatic disease were defined by histologic features: mild (group 2; n = 5), moderate (group 3; n = 6), and severe (group 4; n = 5). Disposition of ICG was studied 3 weeks following the last dose of toxin. A rapid IV injection of 0.5 mg of ICG/kg was administered and serum samples were obtained at certain intervals during 60-minute periods. Serum ICG was analyzed by use of visible spectrophotometry. Disposition kinetics were determined from serum ICG concentrations vs 15- and 60-minute time curves and compared between one another and among groups. Data based on 60-minute time curves were not significantly different from those based on 15-minute curves. Area under the curve for ICG was greatest in group 3. Clearance of ICG was decreased and mean resident time was increased in groups 3 and 4, compared with those in groups 1 and 2. When disposition data (60 minutes) were normalized for differences in hepatic weight among dogs, group-3 mean resident time was significantly greater than that of group 4. This study supports the diagnostic benefits of using ICG disposition kinetics as a method of evaluating hepatic function in dogs with progressive liver disease.
Show more [+] Less [-]Effect of Artemisia Iwayomogi water extract on hepatic injury by carbon tetrachloride in rats - (1) - Effect of serum AST, ALT, LDH activities, lipid content and liver peroxide content.
1992
Kim K.S. | Park J.H.
Ultrastructure of virus particles in the liver of piglets infected with porcine enterovirus serotype 3.
1992
Shin T.K | Lee C.S. | Huh M.D.
A pathological observation on the experimental rabbit viral hepatitis
1992
Jyeong, J.S. (Kyungpook Animal Health Experimental Inst., Taegu (Korea Republic). ) | Kwon, Y.R. | Lee, C.S. (Kyungpook Nat'l Univ., Taegu (Korea Republic). Coll. of Veterinary Medicine) | Shin, T.K. (Cheju Nat'l Univ., Cheju (Korea Republic). Dept. of Veterinary Medicine)
Effect of Artemisia Iwayomogi water extract on hepatic injury by carbon tetrachloride in rats - (2) - Effect on serum ALP, LAP activities, total protein, bilirubin content and liver glycogen content
1992
Kim, K.S. (Kyungpook National University, Taegu (Korea Republic). Department of Veterinary Medicine) | Park, J.H. (Choong Ang Chemical Company, Seoul (Korea Republic))
Indocyanine green excretion test and changes of plasma enzyme activites in Korean native cattle and dairy cattle
1992
Son, M.S. | Choi, I.K. | Kim, J.G. | Hur, J.H. | Kang, C.B. (Gyeongsang Nat'l Univ., Chinju (Korea Republic). Coll. of Veterinary Medicine) | Kim, C.H. (Gyeongsangnamdo Veterinary Service Laboratory, Chinju (Korea Republic). )
The effect of caffeine on promotion step of dimethylnitrosamine-initiated hepatic altered foci in a mid-term induction system
1992
Kim, S.H. (Korea Atomic Energy Research Inst., Seoul (Korea Republic). Korea Cancer Center Hospital) | Lee, C.S. (Kyungpook Nat'l Univ., Taegu (Korea Republic). Coll. of Veterinary Medicine)
Indocyanine green excretion test and changes of plasma enzyme activities in dogs
1992
Kim, C.H. (Gyeongsangnamdo Veterinary Service Laboratory, Chinju (Korea Republic). ) | Choi, I.K. | Son, M.S. | Kim, J.G. | Kang, C.B. (Gyeongsang Nat'l Univ., Chinju (Korea Republic). Coll. of Veterinary Medicine)
Studies on the ploidy distributions of the hepatocytes isolated in hepatocarcinogensis of rats
1992
Choi, K.C. | Lee, Y.S. (Seoul Nat'l Univ., Suwon (Korea Republic). Coll. of Veterinary Medicine)
Anatomical studies on pattern of branches of hepatic arteries in Korean native cattle
1992
Kim, C.S. (Gyeongsang Nat'l Univ., Chinju (Korea Republic). Coll. of Veterinary Medicine)
