Despite of presence of a wide choice of antihelminthics, in the Republic of Belarus it is still a real problem of development of preparations that provide long-term treatment and preventive maintenance efficiency against helminthosis. At the same time, helminthes and anthelminthics render the immunosuppression action. The solution of this problem can be a combined application of antihelminthics and adjuvants. There were proposed preparations Albepolis and Averpolis. Their application made it possible not only to release an organism of animals from parasites, but also to correct the state of immune system. The obtained research data confirm the available data about the immunosuppression action of parasites on an organism of animals. There was also is noted the immunosuppression action of Albendazol and Aversektin C in therapeutic doses. Albendazol possess a wide spectrum of action against trematodes, nematodes, cestodes. It interrupts the metabolism, oppresses fumarate reductase activity and adenosine triphosphate synthesis of a parasite. It proved to be low-toxic for homoiothermal animals. Albendazol rendered positove influence on growth, development and increase of cattle productivity.

Research of immune activity of an experimental series of inactivated vaccine against swine pasteurellosis (Pasteurella) with application of adjuvants of Sepptic Montanida ISA 70 and Montanida ISA 206 was realized in the conditions of the Republic of Belarus. In the capacity of water phase there were used serovars A, B, and D Pasteurella multocida. Research results proved the possibility of application of adjuvants of Sepptic company for the development of vaccine against pasteurellosis. The vaccine with the presented adjuvants after its application did not cause after-trouble effects. In course of immunization there was noted the formation long-lived continuous immunity that was proved by high titres of specific anti-bodies in blood serum in all experimental groups of piglets. Single application of the proposed vaccine in doses 2 or 3 ml per animal proved to be effective. Also it was efficient to apply it twice in doses 1 and 2 ml per animal. For the vaccine production it was proposed to use adjuvant Montanida ISA 206 which did not have high reactogenicity

Analysis of the optimal scheme of doses and rates of combined administration of probiotic Dialakt and immunostimulant Alveozan was realized in the conditions of the Republic of Belarus by the example of 1500 broiler chickens of cross Kobb- 500. Chickens of the first (controlled) group were given only total ration, balanced with the main nutrients. For the chickens of the second group were administrated with immunostimulant Alveozan with water starting from one day old age, every day in dose of 10 mkg/kg of body weight once a day in course of 5 days successively and with 7 days interval till the end of growing period; and probiotic Dialakt was administrated with water in dose of 0,1-0,2 ml/head (10,0-20,0 mln microbial bodies) starting from one day old age, once a day in course of 5 days successively and with 6 and 14 days intervals till the end of growing period. Chickens of the third group were administrated Alveozan in dose of 10 mkg/kg of body weight with drinking water once a day in course of 5 days with 10 days interval till the end of growing period; and Dialakt in dose of 0,1-0,2 ml/head with drinking water starting from one day old age, every day in course of 5 days with 6 and 14 days interval till the end of growing period. The research results showed the following optimal regime of complex application of the analyzed preparations: immunostimulant Dialakt - in dose of 0,1-0,2 ml/head with drinking water starting from one day old age, once a day in course of 3 days successively with 6 and 14 days intervals till the end of growing period; and immunostimulant Alveozan - in doze of 10 mkg/kg of body weight with drinking water once a day in course of 5 days with 10 days interval till the end of growing period. Complex application of Dialakt and Alveozan promoted the increasing of organometric indexes, specific volume and size of thymus in 1,5-1,8 times (P less than 0,01), Fabritsiya bursa - in 2 times (P less than 0,01) and lien - on 11,1% (P less than 0,05)

The dynamics of changes of nonspecific cellular-humoral immunity parameters of sheep in the conditions of in the conditions of oppression of parasympathetic part of autonomic nervous system was studied in the conditions of the Republic of Belarus. For the experimental animals there was applied atropine sulfate. Experiment was realized by an example of two groups (control and experimental) of yeld ewes. Blood was taken from jugular vein before administration of the preparation, and then in 1, 3, 6, 12, 24 hours, 1, 2, 3 days after the beginning of experiment. As a result of realized study there was stated a directly-proportional dependence in changes of phagocytes activity of leukocytes.

Determination of a degree of manifestation of immunomorphological changes in immune system organs of piglets vaccinated against salmonellosis, pasteurellosis and streptoccocusis with SPS vaccine (against salmonellosis (Salmonella), pasteurellosis (Pasteurella) and streptococcus) in combination with immunostimulative drugs and without them was realized in the conditions of the Republic of Belarus. Piglets of 30-35 days old were divided into 4 groups according to the analogue principle. Piglets of the first group were vaccinated against salmonellosis, pasteurellosis and streptoccocusis by SPS vaccine. Piglets of the second group were vaccinated by SPS vaccine with vitamin C. Piglets of the third group were vaccinated by SPS vaccine with immunotstimulant sodium thiosulphate. The fourth (control) group of animals was administrated with normal saline. Animals were immunized twice, intramuscularly with 7 day interval in dose of 4 ml (primary), and 5 ml (secondary). Vitamin С was administrated in dose of 0,05g per head. Sodium thiosulfate was administrated in combination with the vaccine in 30% concentration. The research results showed that immunization with SPS vaccine in combination with sodium thiosulphate and vitamin С promoted the activation of morphological reactions in tissues at locus of vaccine administration, lymphodnudus and lien. Immunization of piglets by SPS vaccine with sodium thiosulphate and with vitamin С activated the limphiod, micro- and macrophage reactions at locus of vaccine administration, as well as in organs and cells there was stated the well-marked vitamin C and glycogen distribution. Sodium thiosulphate showed higher immunostimulate influence in comparison with vitamin C

In the conditions of the Republic of Belarus there was realized a comparative studying of immune reactivity of broiler chickens immunized against Marek's disease by means of vaccines of Russian production. In course of the study it was established, that in broiler chickens vaccinated against Marek's disease (by means of cultural dry viral vaccine on the basis a virus of herpes of turkeys FS-126 and by liquid bivalent cultural virus vaccine Bimarek on the basis of strains of a herpes virus of turkeys and a herpes virus of hens) the revealed morphological changes in immune system organs of did not essentially differ and testified to the development of intense postvaccinal immunity. Economic efficiency of immunization of broiler chicken against Marek's disease under production conditions made 4,87 and 2,94 Belarusian roubles per 1 rouble of expenses, respectively. | Целью исследования явилось сравнительное изучение иммунной реактивности организма цыплят-бройлеров, иммунизированных против болезни Марека вакцинами российского производства. В ходе исследований установлено, что у цыплят-бройлеров, вакцинированных против болезни Марека культуральной сухой вирусвакциной из вируса герпеса индеек ФС-126 и жидкой бивалентной культуральной вирусвакциной Бимарек из штаммов вируса герпеса индеек и вируса герпеса кур выявленные морфологические изменения в органах иммунной системы существенно не отличаются и свидетельствуют о выработке напряженного поствакцинального иммунитета. Экономическая эффективность иммунизации цыплят против болезни Марека в производственных условиях составляет 4,87 и 2,94 рубля на 1 рубль затрат соответственно.

Results of studying of therapeutic efficiency of developed in the Republic of Belarus biological preparation of trial series against salmonellosis of animals and birds in the conditions of experimental salmonellosis of calves were presented. Research results showed that dualfold application of multivalent antitoxic serum against salmonellosis of calves, piglets and birds which was caused by association of S. Dublin, S. typhimurium, and S. enteritidis was accompanied by activation of humoral immunity. It was revealed in increasing of agglutinating activity of blood serum against S. enteritidis – in 11,5 times, against S. typhimurium – in 10,5 times, and against S. Dublin – in 10,0 times in 6 days after introduction of infection (4-th day after second application serum). Content of Ig M in blood serum calves which were treated with experimental serum increased in 2,0 times on the 6-th day after introduction of infection. Quantity of Ig G increased in 2,6 times by the 6-th day after introduction of infection. All these changes were typical for the clinical recovery of animals. Treatment efficiency of application of the analyzed serum was 75%

Determination of the optimal doses of monocomponents of the developing vaccine against rotavirus infection and cattle colibacillosis was realized in the conditions of the Republic of Belarus by the example of 80pregnant cows with body weight 400-450 kg. Immunological efficiency of the analyzed preparations was estimated in accordance with ascending rate of titres of specific antibodies before and after vaccination. Research results showed that the highest degree of expressed immunologic response to the monocomponents was stated for cows vaccinated in dose 2,5 cm3. Increasing of dose up to 5,0 cm3 did not render substantial influence on gain of specific antibodies level in blood serum of immunized cows. Decreasing of dose up to 1,0 cm3 caused to less intensive biosynthesis of antibodies, excluding animals which were administrated with antigen E. coli K88. In the majority of experimental groups of cows in blood serum there was stated the increasing of specific antibodies level after the second administration of the components. The obtained results proved the necessity of dualfold administration of the developing biological preparation. In course of study there was determined the choice of monocomponent doses of the vaccine. The optimal dose of monocomponent against cattle rotavirus in case of infection titre 7,0 lg 50% tissue cytopathic dose was 2,5-5 cm3 pr animal. The highest titres of the specific anticolibacillosis antibodies for E.coli with concentration of bacterial cells 10E9/ml for K99 and A20 in the conditions of antigen administration in dose 2,5 cm3, and for E.coli with adhesive antigens K88 - 1,0 cm3

Due to Herbal medicine it is possible to use cheap and ecological clean preparation. Studied medicinal forms of wormwood bitter (the wormwood bitter extract, fluid extract, Artemizitan) in therapeutic dose stimulate the factors of natural resistance beside animals. Results of studying of lysozyme activity in blood serum have shown that preparations of wormwood bitter have caused authentic increase of this indicator in comparison with control animals, both in pigs, and at sheep. Bactericidal activity of blood serum was authentically more than in control group, both at pigs, and at sheep after introduction of infusion of wormwood bitter. Studying of influence of wormwood bitter on phagocytosis indicators has shown, that all medicinal forms of plant have made stimulating impact on phagocytal activity of neutrophils and phagocytal number both in experiences on pigs, and on sheep. Artemitizan has caused authentic increase and phagocytal index. Thus, the research will be coordinated with literary data, that preparations of wormwood bitter make stimulating impact on indicators of natural resistance of animal blood | Благодаря фитотерапии возможно использование дешевых и экологически чистых препаратов. Изученные лекарственные формы полыни горькой (настой полыни горькой, жидкий экстракт полыни горькой, артемизитан) в терапевтических дозах стимулируют показатели естественной резистентности у животных. Результаты изучения лизоцимной активности в сыворотке крови показали, что препараты полыни горькой вызвали достоверное повышение этого показателя по сравнению с контрольными животными, как у свиней, так и у овец. Бактерицидная активность сыворотки крови была достоверно больше, чем в контрольной группе, как у свиней, так и у овец после введения настоя полыни горькой. Изучение влияния полыни горькой на показатели фагоцитоза показало, что все лекарственные формы растения оказали стимулирующее влияние на фагоцитарную активность нейтрофилов и фагоцитарное число как в опытах на свиньях, так и на овцах. Артемизитан вызвал достоверное повышение и фагоцитарного индекса. Таким образом, наши исследования согласуются с литературными данными, что препараты полыни горькой оказывают стимулирующее влияние на показатели естественной резистентности крови животных

There was studied the features of intra-bodies vessels of turkey thymus of white breed during postnatal ontogenesis. Results of the anatomic and histologic research which allowed to study law of transformations of intra-bodies vessels of turkey thymus are reflected. It is established, that age reorganisation of intra-bodies vessels of turkey thymus is interfaced to development of the basic structural body components. The microvascular thymus channel at the expense of presence hemato-thymus barrier accepts active participation in separation of blood and blood-groove regulation in parenchyma. The maximum factor of thymus blood supply of turkeys is noted in 70 days. Before puberty there is a growth of intra-bodies vessels at the expense of increase in their diameter and a thickness of a wall (mainly media), and after 220 days the haemodynamic potential of body decreases owing to increase of the involutional processes characterized by reduction of vesseldiameter and a thickening of their wall for the account of adventition. In the tabular form the sizes of intracapsular thymic vessels, the sizes of interlobular thymic vessels are presented. | Цель исследования - изучить особенности интраорганных сосудов тимуса индеек белой широкогрудой породы в постнатальном онтогенезе. Отражены результаты анатомических и гистологических исследований, позволивших изучить закономерности преобразований интраорганных артерий тимуса индеек белой породы в период постнатапьного онтогенеза. Установлено, что возрастная перестройка интраорганных артерий тимуса индеек сопряжена с развитием основных структурных компонентов органа. Микрососудистое русло тимуса за счет присутствия гематотимусного барьера принимает активное участие в сепарации крови и регуляции кровотока в паренхиме. Максимальный коэффициент кровоснабжения тимуса индеек отмечен в 70 суток. До полового созревания происходит рост интраоганных артерий за счет увеличения их диаметра и толщины стенки (преимущественно медии), а после 220 суток гемодинамический потенциал органа снижается вследствие нарастания инволюционных процессов, характеризующихся уменьшением диаметра артерий и утолщением их стенки за счет адвентиции. В табличной форме представлены размеры интракапсулярных артерий тимуса, размеры междольковых артерий тимуса.