In the conditions of the Republic of Belarus there was determined the influence of multi-enzymatic veterinary drug preparations Vitazim (contained a complex of enzymes of carbohydrases: xilanase; cellulose; beta-glucanase) and Ehkosim (universal multi-enzymatic complex: beta-glucanase; endo-xilase; and cellulase) on microbial composition of intestinal bacterial population. Research was realized by an example of layer hens of four-linear cross Highsex white at the age of 34-51 weeks. Regimens of administration of the analyzed preparations were presented. Research results showed promoted the development of the regenerative process of physiological media in intestines of poultry which was necessary for subsisting of normal flora of pathogenic bacteria. The studied preparations Vitazim and Ehkosim can be applied for the preventive treatment and therapy of intestinal dysbacteriosis, normalization of its microbial flora, as well as for the antibacterial therapy.

Determination of interactions of monoinfestations and associations of parasites with the normal microflora of intestines of sheep was realized in the conditions of the Republic of Belarus. In the conditions of low associative infestations with Moniezia sp., Strongylata and Strongyloides nematodes, Eimeria protozoa there were stated changes in intestine microflora of sheep: sharp decrease of quantity of bifidus bacteria and lactic acid bacillus, colibacilli with the simultaneous presence of lactose-negative Bacillus coli, increasing number of aerobic bacteria. Recovery of monieziae in the conditions of presence in parasitocoenosis composition of nematodes of suborder Strongylata and Strongyloides species, Eimeria promoted the restoration of quality and quantity composition of microflora of sheep gastrointestinal tract

Complex application Alveozan and Dialact conducts to the increase of perservance of birds on 2,1%, daily average additional weight on 3,6%, and also to the decrease in expenses of forages counting on 1 kg of a gain of live weight by 4,1%. Complex influence of Alveozan and Dialact stimulates growth and development lacto- and bifidoflora in a gastroenteric path, reduces quantity of aerobic microorganisms and oppresses a reproduction and settling of a gastroenteric path by bacteria intestinally-paratyphus groups. The economic efficiency of wording out 11,1 rubles on 1 ruble of additional expenses

There was studied the influence of parasites on quantitative and qualitative characteristics of gastrointestinal microflora of animals. The digestive path represents open system by means of which contact of macroorganism to environment and present at it microbes is carried out. For normal functioning of digestive system the essential role is played by its microbiocenosis condition. During the research some regularities in the rumen and intestine microflora content under the influence of parasites (e.g. N. vitulorum and in assotiation with Eimeria spp. and Strongylata spp) have been postulated. They are expressed by quantity reduction of bifido- and lactoflora with simultaneous increase of content of conditional-pathogenic intestinal stick, aerobic bacillus and micromicet; decrease of quantitative and qualitative structure of protozoa rumen, decrease in their mobility, and also decrease in activity of cicatricial microflora. | Целью работы является изучение влияния паразитов на количественную и качественную характеристики микрофлоры желудочно-кишечного тракта животных. Пищеварительный тракт представляет собой открытую систему, посредством которой осуществляется контакт макроорганизма с внешней средой и присутствующими в нем микробами. Для нормального функционирования пищеварительной системы существенную роль играет состояние ее микробиоценоза. В ходе исследований установлены определенные закономерности в изменении микробиоценоза рубца и кишечника под влиянием паразитарных агентов у телят (а именно, при паразитировании Neoascaris vitulorum в виде моноинвазиии или в ассоциации с Eimeria spp. и Strongylata spp.), которые выражаются уменьшением количества бифидо- и лактофлоры с одновременным увеличением содержания условно-патогенной кишечной палочки, аэробных бацилл и микромицет; нарушением количественного и качественного состава простейших рубца, снижением их подвижности, а также снижением активности рубцовой микрофлоры.

Analysis of efficiency of prebiotics and probiotics and different systems of their application for the focused formation of bacteriocenosis of gastro-intestinal tract of calves was realized in the conditions of the Republic of Belarus. There were used 7 groups of calves: 1 – clinically healthy; 2 – calves with diarrheal syndrome which did not get preparations; 3 – calves were administrated daily with liquid probiotic Bifidoflorin Zhidkij in dose 20 ml in course of 20 days; 4 – calves were administrated daily with prebiotic Biofon with colostral milk or milk in dose 20ml in course of 20 days; 5 – calves were administrated daily with prebiotic Biofon-AIL in dose 20 ml in course 20 days; 6 – calves were administrated with probiotic Bifidoflorin Zhidkij simultaneously with prebiotic Biofon; 7 – calves were administrated with probiotic Bifidoflorin Zhidkij in combination with prebiotic Biofon-AIL. In course of studies there was analyzed the age-specific dynamics of bifidus bacteria, lactic acid bacillus, and Escherichia quantities in calves excrements. Research results showed that application of the proposed prebiotics and probiotics promoted the earlier and active contamination of intestines with obligate anaerobe gram-positive flora with its dominative position in relation to gram-negative nonsporeforming facultative anaerobic flora. At the stage of the second aging immunodeficiency the analyzed preparations rendered the resolving effect. The highest positive indexes were obtained after combined application of probiotic Bifidoflorin Zhidkij with prebiotic Biofon-AIL

Evaluation of influence of monoinvasions and mixed parasitoses on quality and quantity composition of microbiocenosis of gastro-intestinal tract of carnivore was realized in the conditions of the Republic of Belarus. Changes in intestinal microflora of gastro-intestinal tract of dogs with monoinvasions and associated parasitic diseases in comparison with indexes of healthy animals were typical for disbacteriosis and took place towards the reduction of quantity of normal intestinal microflora (bifidobacteria and lactobacteria) and increasing of transient microorganisms: aerobic bacilli, micromicetes, proteus spp, staphylococci, streptococci.