Investigation of method of gastroenteritis treatment of stores by means of application of enterosorbents was realized in the conditions of the Republic of Belarus. For the experiment there was used preparation Lactofiltrum containing 80% of hydrolyzed lignin and 20% of lactulose applied in dose of 0,3 g/kg once a day during 7 days. Efficiency of application of Lactofiltrum was compared with enterosorbent SV-2, which contained alcaline hydrolyzed lignin applied in dose of 1 g/kg once a day during 7 days. Four experimental groups piglets sick with gastroenteritis in the age of 1,5-2 months, with body weight of 15-17 kg were used in the experiment. The first group piglets were entered 0,3 g/kg body mass of Lactofiltrum once a day during 7 days. The second group piglets were entered enterosorbent SV-2 in dose of 1 g/kg in course of 7 days. For the piglets of the third group there was applied the complex of analysed preparations in same course of treatment. The fourth group of piglets was entered enrotim 10% in dose of 1 ml/ 20 kg of body mass. All animals had the same conditions of feeding and keeping. Research results showed that application of Lactofiltrum, SV-2 and their complex provided high antioxidative, detoxification, gepathoprotective activities. These preparations proved to be effective means of pathogenetic therapy for the treatment of gastroenteritis of piglets, both as individual preparations, and complex application. Comparative estimation of treatment methods of gastroenteritis showed that these preparations (except enrotim 10%) made it possible to regulate the metabolic processes due to elimination of intoxication, positive influence on hematopoiesis. The preparations lowered the duration of clinic manifestation of a disease and facilitated its duration, had gepathoprotective and antioxidative activity

Determination of degree and relations between derangements of metabolic processes in calves with respiratory syndrome in the milking period was realized in the conditions of the Republic of Belarus. Research results showed that the calves with the respiratory syndrome had expressed metabolic processes disturbances, which were marked in the analyzed biochemical blood indexes (total protein; albumins; urea; creatinine; glucose; cholesterin; triglycerids; bilirubin; ALP; AAT; SGPT; calcium; phosphorous; magnesium; iron; manganese; cobalt; cuprum; zinc). In calves with respiratory syndrome there was noted the increased content of crude protein in blood serum (71,42 +/- 2,57 g/l P less than 0,05), low urea level (3,08 +/- mmol/l). There was the increased level of creatine (574,11 +/- 65,26 mkmol/l; P less than 0,01) and bilirubin (8,11 +/- 1,15 mkmol/l; P less than 0,05). Glucose concentration in blood of diseased calves was at below standard level (3,49 +/- 0,69 mmol/l). Glucose indexes varied and were changing during a day; and depended on muscular activity, intervals between feeding and hormonal regulation. Diseased calves had high cholesterol level in blood serum (4,07 +/- 0,34 mmol/l; P less than 0,05), which was stated in case of liver disease and hypothyroidism. Phosphor level was higher than the standard indexes of healthy calves (2,85 +/- 0,03 and 2,05 +/- 0,05, respectively). Content of magnesium, cobalt and zinc in blood of the diseased calves was lower than in healthy ones. Calves with respiratory pathology had protein, fat, hydro-carbonic and mineral metabolic processes

Investigation of acute and subchronic (chronic) toxicity of complexinates of trace elements in experiments with calves was realized in the conditions of the Republic of Belarus. The realized experiments were based on developed in Belarus veterinary preparations for the treatment and prevention of diseases connected with disorders of trace elements exchange containing chelate compounds of trace elements with sodium ethylene diamine acetate: Cuprovet (on the basis of CuNa); Cobalvet (on the basis of CoNa), Zinkovet (on the basis of ZnNa), and Feravet (on the basis of FeNa). There were the following indexes of ferrum in nephros - 55,3 +/- 2,26, in muscles - 134 +/- 26,6 mkg/g, and in liver - 565 +/- 35,5 mkg/g after administration of Feravet. There were the following index of zinc in nephros - 56,3 +/- 2,64, in muscles -25, 8 +/- 1,23 and in liver - 84,4 +/- 3,29 mkg/g after administration of Zinkovet. There were the following indexes of cuprum in nephros - 4,1 +/- 0,325, in muscles - 2,33 +/- 0,117, and in liver - 12,3 +/- 1,12 mkg/g after administration of Cuprovet. There were the following indexes of cobalt in nephros - 40,35 +/- 2,29, in muscles - 12,5 +/- 0,98, and in liver - 126,5 +/- 10,45 ng/g after administration of Cobalvet. Parameters of toxicity of all preparations were by the example of laboratory mice, rats and calves given. Content of trace elements in blood of calves in dynamics of the experiment was analyzed. There were determined parameters of acute toxicity of the analyzed preparations: they all could be referred to substance hazard category 4 (low-hazardous substances). The determined parameters of acute toxicity made it possible to recommend them for treatment and prophylaxis of microelementoses of cattle, as well as to use them as feed additives taking into consideration that defect action levels of the analysed preparations exceed the deficiency needs of cattle in case of their limited cumulation

Investigation of efficiency of electrochemically active solutions in complex therapy of calves with diseases of the digestive apparatus and respiratory organs was realized in the conditions of the Republic of Belarus. Calves diseased with dyspepsia and bronchopneumonia were chosen for investigation of gastrointestinal diseases and respiratory diseases. At the first stage there was studied the therapeutic efficacy of water solution of electrochemically active neutral anolyte and sodium hypochloride solution Akvamed for calves sick with dyspepsia. At the second stage there was analyzed the therapeutic efficacy of 0,04 % solution sodium hypochloride Akvamed for the treatment of bronchopneumonia of calves. Research results showed that inclusion into complex therapeutic regimen of calves of electrochemically active solutions promoted the reduction of disease duration and severity. Electrochemically active solutions had high biocidal activity and could be produced in large volumes, had practical safety, low price and acute therapeutic effect

Realization of veterinary and sanitary examination of meat and slaughter products of calves treated with hyperimmune serum against cattle colibacillosis was conducted in the conditions of the Republic of Belarus. There were formed two groups calves of 3-5 days old. Calves of the first group were treated with serum biological preparation of trial series produced at Vitebsk Biofabrika (Belarus). Calves of the second group were intact animals. Calves of each group were killed in 14 days after preparation application for realization of veterinary-sanitary examination. Slaughter meat was studied in accordance with the following indexes: pH; peroxidase activity; presence of products of primary protein breakdown; moisture content; relative biological value of meat; bacterial examination. The research results of organoleptic indicators showed that meat of both groups corresponded to the standards. Hyperimmune serum against colibacillosis of live-stock animals did not render negative influence on organoleptic, physical and chemical indexes of meat. Indexes of the relative biological value in meat of calves treated with the examined serum were higher than the similar indexes of intact animals. Meat of all examined animals did not have any germs of toxico-infections and toxicoses

Increase of diets nutrition energy in our experiment showed no significant effect on usage of nitrogen in feeds. Diets with different energy levels have no negative effect on hematological indices of animals

Investigation of connection of experimental trichophytosis and relations between changes of clinical implications of disease and dimensions of some immunological indexes was realized in the conditions of the Republic of Belarus. At the first stage of the experiment there analyzed 48 guinea pigs (Cavia porcellus) infected with Trichopyton verrucosum. Phagocytic ability of phagocytes and level of circulating antibodies in indirect hemagglutination test were investigated each 5 days before and during disease. The second stage was realized by the example of 2,5-6 months old calves. In course of study there were analyzed blood and blood serum indexes, indexes of nonspecific resistance, as well as some indexes of cell-mediated immune response and antibody mediated immunity. Comparative analysis the following morphological and biochemical blood indexes of clinically healthy calves, calves after trichophytosis, and calves sick with mild, moderate and severe of disease were presented: erythrocytes; hemoglobin; leukocytes; basophils; eosinophiles; rods; microxyphils; lymphocytes; monocytes; ESR; total albumin; albumins; alpha globulins; beta globulins; gamma globulins; carotene; calcium; inorganic phosphorous; alkaline reserve; copper. The realized experiment made it possible to conclude that determination intensity of leukocyte absorption of microconidia of the agent, antibodies against the agent, and specific for cytoplasm fungus, morphological and biochemical blood indexes made it possible to control the development of inflammatory phenomenon in centers of infection, as well as to predict the formation of face, infiltrative and suppurant disease forms

Analysis of efficiency of prebiotics and probiotics and different systems of their application for the focused formation of bacteriocenosis of gastro-intestinal tract of calves was realized in the conditions of the Republic of Belarus. There were used 7 groups of calves: 1 – clinically healthy; 2 – calves with diarrheal syndrome which did not get preparations; 3 – calves were administrated daily with liquid probiotic Bifidoflorin Zhidkij in dose 20 ml in course of 20 days; 4 – calves were administrated daily with prebiotic Biofon with colostral milk or milk in dose 20ml in course of 20 days; 5 – calves were administrated daily with prebiotic Biofon-AIL in dose 20 ml in course 20 days; 6 – calves were administrated with probiotic Bifidoflorin Zhidkij simultaneously with prebiotic Biofon; 7 – calves were administrated with probiotic Bifidoflorin Zhidkij in combination with prebiotic Biofon-AIL. In course of studies there was analyzed the age-specific dynamics of bifidus bacteria, lactic acid bacillus, and Escherichia quantities in calves excrements. Research results showed that application of the proposed prebiotics and probiotics promoted the earlier and active contamination of intestines with obligate anaerobe gram-positive flora with its dominative position in relation to gram-negative nonsporeforming facultative anaerobic flora. At the stage of the second aging immunodeficiency the analyzed preparations rendered the resolving effect. The highest positive indexes were obtained after combined application of probiotic Bifidoflorin Zhidkij with prebiotic Biofon-AIL

Results of studying of therapeutic efficiency of developed in the Republic of Belarus biological preparation of trial series against salmonellosis of animals and birds in the conditions of experimental salmonellosis of calves were presented. Research results showed that dualfold application of multivalent antitoxic serum against salmonellosis of calves, piglets and birds which was caused by association of S. Dublin, S. typhimurium, and S. enteritidis was accompanied by activation of humoral immunity. It was revealed in increasing of agglutinating activity of blood serum against S. enteritidis – in 11,5 times, against S. typhimurium – in 10,5 times, and against S. Dublin – in 10,0 times in 6 days after introduction of infection (4-th day after second application serum). Content of Ig M in blood serum calves which were treated with experimental serum increased in 2,0 times on the 6-th day after introduction of infection. Quantity of Ig G increased in 2,6 times by the 6-th day after introduction of infection. All these changes were typical for the clinical recovery of animals. Treatment efficiency of application of the analyzed serum was 75%

Possibility of increasing of meat productivity of ducklings of Temp cross after application of duck parental forms of German selection was studied in the conditions of the Republic of Belarus. In course of study there was revealed the dynamics of changes of live weight and feed expenses for live weight gain of linear and hybrid ducklings; as well as their meat qualities were determined. In course of studied there were used linear and hybrid ducklings obtained after crossbreeding of parental forms of Belarusian and German crosses of Peking breeds. There were formed 8 groups of one-day old ducklings. In the father's line the first (control) group was presented by pure bred line T1 of Temp cross; in the second group – by hybrid NT1 x T1, obtained after the direct crossing of male ducks of NT1 with female ducks of T1 lines; in the third group – by hybrid T1 x NT1, obtained after the backcrossing of male ducks of T1 with female ducks of NT1 lines; in the fourth group the combination NT1 was obtained by NT1 x NT1. In fifth group the maternal line was presented by pure line of T2 Temp cross (control); the sixth group was presented by hybrid T2N x T2 obtained after direct crossing of male ducks of T2N line with maternal ducks of T2 line; in the eighth group the combination T2N was obtained by T2N x T2N. Research results showed that application of Germal ducks in schemes of crossbreeding rendered the positive influence on live weight increasing of ducklings of father's line. In the carcasses of hybrid ducklings of all studied crossbreeds there was stated the decreasing number of skin with adipose layer and increasing number muscles including the pectoralis