In the conditions of the Republic of Belarus there was studied the formation of nonspecific protection factors of the first year foals. By a principle of conditional analogues there was generated a group of clinically healthy foals at which monthly from bulbar veins there were taken tests of blood for hematological and biochemical analysis. From the obtained data it was visible, that within the first year of foal life there were taking place the processes of formation of nonspecific protection factors of an organism which were accompanied by a gradual increasing of quantity of erythrocytes, haemoglobin, leukocytes, certain change in the diagramme, and also increasing of bactericidal and lysozyme activity of blood serum. However, at seven-month age there was marked a considerable decrease in number of erythrocytes, leukocytes, concentration of haemoglobin, bactericidal and lysozyme activity of blood serum is marked, in leukogram share reduction of segmented neutrophils, and at the same time, the content of eosinocytes and lymphocytes increased. It testified the decreasing of protective forces of an organism during this period. Consequently, the seventh month in the postnatal period of foal life proved to be the most critical.

As a result of realized in the conditions of the Republic of Belarus research it was revealed that application of immunostimulative drugs of sodium thyosulphate and vitamin С (ascorbic acid) in combination with a vaccine against salmonellosis, pasteurellosis and streptococcosis of pigs promoted the statistically authentic increasing of leukocytes, absolute quantity of T- and B-lymphocytes content in peripheral blood. Also, it promoted the activation of phagocytic activity and digested ability of neutrophils; activization of mieloblastic hemopoiesis and decreasing of erythrocytopoiesis; activization of morphological reactions in a tissue at a place of administration of the vaccine, lymphatic nodules and spleen. | Проведенные исследования показали, что применение иммуностимуляторов натрия тиосульфата и витамина С с вакциной против сальмонеллеза, пастереллеза и стрептококкоза свиней способствует статистически достоверному повышению в периферической крови содержания лейкоцитов, абсолютного количества Т- и В-лимфоцитов, активизации фагоцитарной активности и перевариваемой способности нейтрофилов; активизации миелобластического кроветворения и снижению эритропоэза; активизации морфологических реакций в ткани на месте введения вакцины, лимфоузлах и селезенке.

Research on determination of changes of morphological and biochemical blood indexes of sheep with fasciolosis after application of the drug Klozantsid (menizol 20%, produced in the Republic of Belarus) was carried out. The research realized in the conditions of the Scientific and Research Institute of Applied Veterinary Medicine and Biotechnology of the Vitebsk State Academy of Veterinary Medicine. In course of the experiment there were used sheep of Romanovskaya breed at the age from 1,5 till 5 years which were spontaneously infected with fasciola. The experimental animals were administrated with the examined antihelminthic preparation. It was found out that after administration of the preparation there was stated the restoration of a level of erythrocytes, haemoglobin, leukocytes, enzymes, proteins and other blood indexes. Klozantsid did not render toxic influence on studied animals. | Проведены исследования по выяснению изменений морфологических и биохимических показателей крови у овец с фасциолёзной инвазией при применении препарата Клозанцид. Исследования проводили в условиях клиники и лаборатории кафедры паразитологии и инвазионных болезней, лаборатории кафедры клинической диагностики, научно-исследовательского института прикладной ветеринарной медицины и биотехнологии учреждения образования «Витебская ордена «Знак Почёта» государственная академия ветеринарной медицины». Объектом исследования являлись овцы романовской породы в возрасте от 1,5 до 5 лет, спонтанно зараженные фасциолами, которым применяли испытуемый препарат, обладающий антигельминтными свойствами. При этом выяснено, что после введения препарата происходит восстановление уровня эритроцитов, гемоглобина, лейкоцитов, ферментов, белков и других показателей. Клозанцид не оказывал токсического влияния на организм животного.

In the conditions of the Republic of Belarus there was determined the parasitizing influence of Oesophagostomum and their larvae on a metabolism of experimentally infested animals. In course of the study there were generated experimental and control groups of two-month old piglets. Animals of the experimental group were infested in a dose of 15000 invasion larvae per one kg of body weight. Animals of the control group were not infested. Infestation was realized through a mouth with invasion larvae with wet forage. Invasion larvae received by cultivation of excrement tests from infested pigs at temperature of 24 deg C. As a result of the realized research it was established, that Oesophagostomum invasion rendered a substantial influence on the experimental animals. At bimestrious pigs after the experimental infection with Oesophagostomum larvae there were stated the following changes: the disease on 4-30th day was characterized by frustration of function of a gastroenteric path - diarrhea, fever, anaemia, and in the subsequent - stagnation and juvenilism of animals. Oesophagostomum in a host organism caused the pathological changes of haemotological and biochemical blood value which were expressed in quantity decrease of erythrocytes, concentration of haemoglobin, leucocytosis. Eosinophilia was observed in a leukogram. In blood serum there was stated the lowering of crude protein and its fractions content; gradually, but authentically there was noted the increasing of activity serum glutamic oxalacetic transaminase and glutamic-pyruvic transaminase. Bactericidal and lysozymic activity of blood serum decreased. Activity of alkaline phosphatase increased.

In the conditions of the Republic of Belarus there was studied the influence of herbal infusion, tincture, liquid and dry extracts of elecampane (Inula helenium) on morphological and biochemical indexes of pig blood. In course of the study it was established, that preparative forms of elecampane stimulated the formation of blood corpuscle, and also increased of the hemoglobin level in blood of pigs. Administration of elecampane preparations did not cause any authentic changes in blood leukogram of swine; all indicators were within normal limits. Elecampane preparations did not cause changes on the part of biochemical blood indexes of and did not influence the activity of enzymes. Research results showed that herbal infusion, tincture, liquid and dry extracts of elecampane did not render negative influence on swine.

In the conditions of the Republic of Belarus there was realized a comparative studying of immune reactivity of broiler chickens immunized against Marek's disease by means of vaccines of Russian production. In course of the study it was established, that in broiler chickens vaccinated against Marek's disease (by means of cultural dry viral vaccine on the basis a virus of herpes of turkeys FS-126 and by liquid bivalent cultural virus vaccine Bimarek on the basis of strains of a herpes virus of turkeys and a herpes virus of hens) the revealed morphological changes in immune system organs of did not essentially differ and testified to the development of intense postvaccinal immunity. Economic efficiency of immunization of broiler chicken against Marek's disease under production conditions made 4,87 and 2,94 Belarusian roubles per 1 rouble of expenses, respectively. | Целью исследования явилось сравнительное изучение иммунной реактивности организма цыплят-бройлеров, иммунизированных против болезни Марека вакцинами российского производства. В ходе исследований установлено, что у цыплят-бройлеров, вакцинированных против болезни Марека культуральной сухой вирусвакциной из вируса герпеса индеек ФС-126 и жидкой бивалентной культуральной вирусвакциной Бимарек из штаммов вируса герпеса индеек и вируса герпеса кур выявленные морфологические изменения в органах иммунной системы существенно не отличаются и свидетельствуют о выработке напряженного поствакцинального иммунитета. Экономическая эффективность иммунизации цыплят против болезни Марека в производственных условиях составляет 4,87 и 2,94 рубля на 1 рубль затрат соответственно.