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Immuno-enhancing Effects of Lactobacillus salivarius JWS 58 and Lactobacillus plantarum JWS 1354 isolated from duck
2011
Choi, H.J., Chungbuk National University, Cheongju, Republic of Korea | Kim, J.Y., Chungbuk National University, Cheongju, Republic of Korea | Shin, M.S., Chungbuk National University, Cheongju, Republic of Korea | Lee, S.M., Chonbuk National University, Iksan, Republic of Korea | Lee, W.K., Chungbuk National University, Cheongju, Republic of Korea
Lactobacillus salivarius JWS 58 (JWS 58) and Lactobacillus plantarum JWS 1354 (JWS 1354) are isolated from duck intestine and have ability to produce bacteriocin. The objective of this study was to evaluate the immunomodulatory effects of JWS 58 and JWS 1354. The nitric oxide (NO) and cytokines (IL-1β and TNF-α) were measured in C57BL/6 mouse peritoneal macrophages to determine immune enhancing effects of JWS 58 and JWS 1354. A Listeria (L.) monocytogenes challenge mice model was used to evaluate immune enhancement ability of JWS 58 and JWS 1354 in vivo. The results showed that JWS 58 and JWS 1354 increased the production of NO or cytokines by peritoneal macrophages and that oral administration of viable probiotic strains in mice elicited the immuno-modulatory effect upon L. monocytogenes challenge. JWS 1354 showed stronger immune enhancing effects than JWS 58. Collectively, this study demonstrated that Lactobacillus strain JWS 58 and JWS 1354 possess immune enhancing effect. Furthermore, two stains are expected to use feed supplement to prevent diseases by pathogenic bacteria through releasing bacteriocin and enhancing host immune responses in animal.
Show more [+] Less [-]Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats
2013
Oh, H., Jeju National University, Jeju, Republic of Korea | Ahn, M., Jeju National University, Jeju, Republic of Korea | Matsumoto, Y., Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan | Shin, T., Jeju National University, Jeju, Republic of Korea
To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.
Show more [+] Less [-]Involvement of macrophages in germ cell death in the rat testis with acute experimental testicular torsion
Moon, C.J.;Shin, T.K.(Cheju National University, Jeju, Republic of Korea)E-mail:shint@cheju.ac.kr
Ischemia/reperfusion(I/R) injury of the rat testis causes germ cell death and infiltration of inflammatory cells. To investigate the mechanism of germ cell death in torsion of the rat testis, apoptosis and macrophage activation were studied using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling(TUNEL) method and immunohistochemistry in the testes of Sprague-Dawley rats subjected to 1.5 h of ischemia, followed by 0, 1, 3, 6, 12, 24, 48 and 96 h of reperfusion.
Show more [+] Less [-]Immunohistochemical localization of galectin-3 in the brain with Theiler's murine encephalomyelitis virus (DA strain) infection
2013
Shin, T., Jeju National University, Jeju, Republic of Korea | Carrillo-Salinas, F.J., Instituto Cajal, CSIC, Madrid, Spain | Mart'nez, A.F., Instituto Cajal, CSIC, Madrid, Spain | Mecha, M., Instituto Cajal, CSIC, Madrid, Spain | Guaz,a C., Instituto Cajal, CSIC, Madrid, Spain
Galectin-3 is a β-galactoside-binding lectin that plays a role in neuroinflammation through cell migration, proliferation, and apoptosis. In the present study, regulation of galectin-3 was examined in the brain of mice infected with the Daniel strain of Theiler’s murine encephalomyelitis virus (TMEV) at days 7 and 81 post-infection by immunohistochemistry. Immunohistochemistry revealed that galectin-3 was mainly localized in ionized calcium-binding adapter 1-positive macrophages/activated microglia, but not in Iba-1-positive ramified microglia. Galectin-3 was also weakly detected in some astrocytes in the same encephalitic lesions, but not in neurons and oligodendrocytes. Collectively, the present findings suggest that galectin-3, mainly produced by activated microglia/macrophages, may be involved in the pathogenesis of virus induced acute inflammation in the early stage as well as the chronic demyelinating lesions in Daniel strain of TMEV induced demyelination model.
Show more [+] Less [-]Overexpression of Galectin-3 in Macrophages of C57BL/6 mice with Experimental Autoimmune Encephalomyelitis
2011
Kim, D.S., Jeju National University, Jeju, Republic of Korea | Hwang, I.S., Jeju National University, Jeju, Republic of Korea | Park, S.J., Jeju National University, Jeju, Republic of Korea | Ahn, G.N., Jeju National University, Jeju, Republic of Korea | Park, S.J., Kyungpook National University, Daegu, Republic of Korea | Park, H.J., Jeju National University, Jeju, Republic of Korea | Joo, H.G., Jeju National University, Jeju, Republic of Korea | Jee, Y.H., Jeju National University, Jeju, Republic of Korea
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease in the murine central nervous system (CNS) and has long been used as an animal model for human multiple sclerosis. Development of EAE requires coordinated expression of a number of genes that are involved in the activation and effector functions of inflammatory cells. Galectin-3 (Gal-3) is a member of the beta-galactoside-binding lectin family and plays an important role in inflammatory responses through its functions on cell activation, cell migration or inhibition of apoptosis. We investigated the functional role of Gal-3 in EAE mice following immunization with myelin oligodendrocyte glycoprotein (MOG)∧35-55 peptide. During the peak stage of EAE, the localization of Gal-3 in inflammatory cells markedly increased in subarachnoid membranes and perivascular regions of CNS. In contrast, Gal-3 was weakly detected in cerebrum and spinal of the recovery stage of EAE. Consistent with this finding, western blot analysis revealed that Gal-3 expression was significantly increased at the peak stage while it was slightly decreased at the recovery stage in the CNS. In addition, the population of CD11b+ macrophage expressing Gal-3 in spleen of EAE mice was markedly increased compared with control mice. In fact, most of activated macrophages isolated from spleen of EAE mice expressed Gal-3. Taken together, our results demonstrate that the over-expression of Gal-3 in activated macrophages may play a key role in promoting inflammatory cells in the CNS during EAE.
Show more [+] Less [-]Expression of galectin-3 in the spinal cords of Lewis rats and NOD mice with experimental autoimmune encephalomyelitis
Kim, H.C.;Joo, H.G.;Moon, C.J.;Ahn, M.J.;Jee, Y.H.;Lim, Y.K.;Shin, T.K.(Cheju National University, Jeju, Republic of Korea)E-mail:shint@cheju.ac.kr | Koh, C.S.(Shinshu University, Matsumoto, Japan)
The aim of this study was to evaluate the expression of galectin-3, one of beta-galactoside-binding proteins, in the experimental autoimmune encephalomyelitis(EAE) model of Lewis rats or non-obese diabetic (NOD) mice. Western blot analysis showed that galectin-3 was weakly expressed in the spinal cords of complete Freund's adjuvant(CFA) immunized control rats. In EAE, however, galectin-3 expression was significantly increased at the peak stage(days 14 post-immunization), while it was decreased slightly at the recovery stage(day 21 post-immunization).
Show more [+] Less [-]Role of obioactin on toxoplasmacidal activity within mouse peritoneal macrophages
1994
Yang, M.P. (Chungbuk National University, Cheongju (Korea Republic). College of Veterinary Medicine)
Isolation of adenovirus from porcine alveolar macrophages
1997
Kweon, C.H. | Cho, J.J. | Kwon, B.J. | Song, J.Y. (National veterinary Research Institute, RDA, Anyang (Korea Republic)) | Chae, C.H. (Seoul National University, Suwon (Korea republic). College of Veterinary Medicine)
Effect of Bupleurum falcatum on the immune system
1994
Cho, J.G. | Kim, J.M. (Chonbuk National University, Chonju (Korea Republic). College of Veterinary Medicine)