In the conditions of the Republic of Belarus there were studied circadian rhythms of some haemotological and biochemical blood indexes of clinically healthy calves and calves with a respiratory syndrome. There was analyzed the efficiency of administration a new complex mineral preparation CMP for correction of internal desynchronoses in complex therapy of calves with respiratory pathologies. Diseases of calves with a respiratory syndrome were accompanied by infringements of circadian fluctuations rhythm (internal desynchronosis) of haemotological and biochemical blood indexes. Application of an antimicrobial preparation Ampicillin for treatment of respiratory diseases of calves promoted the recovery of calves. Introduction of CМP preparation into therapeutic regimen of calves with respiratory syndrome proved to be rather effective; it promoted the correction of metabolic desynchronoses which accompanied the basic disease. Combined application of CМP and Ampicillin made it possible to speed up the clinical recovery of calves and on 30% to prevent animal mortality.

In the conditions of the Republic of Belarus there was studied a comparative efficacy of methods of drug administration for diseased animals with respiratory diseases. It was stated that enteral (internal) administration of Tromexin in a complex therapy of calves with respiratory pathology possesses rendered low therapeutic efficacy and could have a lethal outcome. Parenteral (intramuscular) administration of Enrotil and Dexafort for a complex therapy of calves with respiratory pathology rendered a moderate therapeutic efficacy and could lead to animal's state improvement. Parenteral (intravenous) administration of hypertonic solutions of norsulfazol, calcium chloride, sodium chloride and glucose in complex therapy of calves diseased with a respiratory pathology proved to render a high therapeutic efficacy and may lead in a complete clinical recovery.

In the conditions of the Republic of Belarus there was determined the therapeutic efficacy of combined application of a complex antibacterial veterinary drug (containing lincomycin and spectinomycin) and Trivitim for the treatment of calves with respiratory diseases. In course of the study of 12 1-1,5 month old calves with respiratory diseases there were analyzed the hematological blood indexes, white blood cell differential and content of total protein in blood serum before the beginning of treatment and on the seventh and fourteenth days after beginning treatment. Research results showed that application the antibacterial veterinary drug in complex therapy with Trivitim in treatment of calves proved to be efficient. Their administration shortened the terms of recovery and prevented animal death as well as promoted the normalization of hematological and biochemical blood indexes.

Results of serological examinations of blood serum of sheep on revelation of virus respiratory infections (parainfluenza-3, adenovirus and respiratory syncytial) realized in the conditions of the Kyrgyz Republic were presented. Research results showed that in farm and peasant farm holdings of all studied districts of the Kyrgyz Republic of three types of pneumo viral infections simultaneously give high levels of antibody titers in relation to parainfluenza-3 – 1:128, adenovirus – 1:32, respiratory syncytial infection – 1:16. In some districts sheep population was diseased only by parainfluenzal infection in relation with titer of specific antibodies 1:256

Determination of degree and relations between derangements of metabolic processes in calves with respiratory syndrome in the milking period was realized in the conditions of the Republic of Belarus. Research results showed that the calves with the respiratory syndrome had expressed metabolic processes disturbances, which were marked in the analyzed biochemical blood indexes (total protein; albumins; urea; creatinine; glucose; cholesterin; triglycerids; bilirubin; ALP; AAT; SGPT; calcium; phosphorous; magnesium; iron; manganese; cobalt; cuprum; zinc). In calves with respiratory syndrome there was noted the increased content of crude protein in blood serum (71,42 +/- 2,57 g/l P less than 0,05), low urea level (3,08 +/- mmol/l). There was the increased level of creatine (574,11 +/- 65,26 mkmol/l; P less than 0,01) and bilirubin (8,11 +/- 1,15 mkmol/l; P less than 0,05). Glucose concentration in blood of diseased calves was at below standard level (3,49 +/- 0,69 mmol/l). Glucose indexes varied and were changing during a day; and depended on muscular activity, intervals between feeding and hormonal regulation. Diseased calves had high cholesterol level in blood serum (4,07 +/- 0,34 mmol/l; P less than 0,05), which was stated in case of liver disease and hypothyroidism. Phosphor level was higher than the standard indexes of healthy calves (2,85 +/- 0,03 and 2,05 +/- 0,05, respectively). Content of magnesium, cobalt and zinc in blood of the diseased calves was lower than in healthy ones. Calves with respiratory pathology had protein, fat, hydro-carbonic and mineral metabolic processes

Investigation of efficiency of electrochemically active solutions in complex therapy of calves with diseases of the digestive apparatus and respiratory organs was realized in the conditions of the Republic of Belarus. Calves diseased with dyspepsia and bronchopneumonia were chosen for investigation of gastrointestinal diseases and respiratory diseases. At the first stage there was studied the therapeutic efficacy of water solution of electrochemically active neutral anolyte and sodium hypochloride solution Akvamed for calves sick with dyspepsia. At the second stage there was analyzed the therapeutic efficacy of 0,04 % solution sodium hypochloride Akvamed for the treatment of bronchopneumonia of calves. Research results showed that inclusion into complex therapeutic regimen of calves of electrochemically active solutions promoted the reduction of disease duration and severity. Electrochemically active solutions had high biocidal activity and could be produced in large volumes, had practical safety, low price and acute therapeutic effect

Immunomorphological changes in young hens vaccinated with an associated inactivated emulsion vaccine against bursal disease, infectious bronchitis and Newcasle disease was realized in the conditions of the Republic of Belarus. Replacement young hens of 130-158 days old were divided into 2 groups with 200 head in each according the analogue principle. At the age of 130 days old the first experimental group of chickens was immunized against bursal disease, infectious bronchitis and Newcasle disease with a liquid inactive emulsion vaccine (produced in the republic of Belarus) in dose of 0,5 ml intramuscularly. In course of the experiment chickens from each group were killed on the third, seventh, fourteenth, twenty-first and twenty-eighth days. For the analysis of immunomorphological reaction there were tested tissue pieces from the places of vaccine administration, as well as thymus, bursa of Fabritius, lien, cecal tonsils and Garder's gland. Research results showed that in tissues in places of the vaccine administration there were developed hemorrhages, serous inflammatory edema, necrobiosis and necrosis of muscular fibers, inflammatory cellular infiltration, and moderate plasmocytic reaction. At a later stage at the places of damaged structures there was noted the development of granulation tissue with presence of some lymphoid nodules. In response to vaccination in the central organs of poultry immunity there was stated the sinuated changes of morphological indexes. Immunization of chickens against infectious bursal disease, infectious bronchitis and Newcasle disease promoted the increasing of absolute weight of lien, activation of blastic and plasmocytic reaction in bursa of Fabritius and lien and did not render substantial influence on immunomorphological indexes of cecal tonsils and Garder's gland