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Increased osteopontin expression in activated glial cells in experimental autoimmune encephalomyelitis
2006
Park, S.J. (Cheju National University, Jeju, Republic of Korea) | Hwang, I.S. (Cheju National University, Jeju, Republic of Korea) | Kim, G.B. (Cheju National University, Jeju, Republic of Korea) | Shin, T.K. (Cheju National University, Jeju, Republic of Korea) | Jee, Y.H. (Cheju National University, Jeju, Republic of Korea), E-mail: yhjee@cheju.ac.kr
Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). Autoimmune inflammation is maintained by secretion of a large number of protein. Previous studies have suggested that transcripts encoding osteopontin (OPN) are frequently detected in the mRNA population of MS plaques. To elucidate the functional role of OPN in initiation and development of EAE, we examined the expression and localization of OPN in the spinal cord during acute EAE.
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