The metabolism disorders of subclinical nature in pregnant cows are characterized with intoxication processes development, swift of acid - alkaline balance and cytolyses activation. The listed factors promote occurrence of neonatal pathology - congenital calve hypotrophy. Degree of display of the given pathology depends on severity level of the metabolism disorders in pregnant dry cows. In the tabular form results of the spent haemotological and biochemical research are presented: haemotological and biochemical indicators of blood pregnant dry cows for the 14-21 day prior to assumed calving; haemotological, biochemical and immunologic indicators of blood of newborn calves with various degree of antenatal hypotrophy. | Нарушение обмена веществ субклинической природы у стельных сухостойных коров характеризуется развитием интоксикационных процессов, сдвигом кислотно-щелочного равновесия и активацией цитолиза. Перечисленные факторы способствуют возникновению неонатальной патологии - врожденной гипотрофии телят. Степень проявления данной патологии зависит от степени тяжести нарушения обмена веществ у стельных сухостойных коров. В табличной форме представлены результаты проведенных гематологических и биохимических исследований: гематологические и биохимические показатели крови стельных сухостойных коров за 14-21 день до предполагаемого отела; гематологические, биохимические и иммунологические показатели крови новорожденных телят с различной степенью антенатального недоразвития.

In the conditions of the Republic of Belarus there was determined the parasitizing influence of Oesophagostomum and their larvae on a metabolism of experimentally infested animals. In course of the study there were generated experimental and control groups of two-month old piglets. Animals of the experimental group were infested in a dose of 15000 invasion larvae per one kg of body weight. Animals of the control group were not infested. Infestation was realized through a mouth with invasion larvae with wet forage. Invasion larvae received by cultivation of excrement tests from infested pigs at temperature of 24 deg C. As a result of the realized research it was established, that Oesophagostomum invasion rendered a substantial influence on the experimental animals. At bimestrious pigs after the experimental infection with Oesophagostomum larvae there were stated the following changes: the disease on 4-30th day was characterized by frustration of function of a gastroenteric path - diarrhea, fever, anaemia, and in the subsequent - stagnation and juvenilism of animals. Oesophagostomum in a host organism caused the pathological changes of haemotological and biochemical blood value which were expressed in quantity decrease of erythrocytes, concentration of haemoglobin, leucocytosis. Eosinophilia was observed in a leukogram. In blood serum there was stated the lowering of crude protein and its fractions content; gradually, but authentically there was noted the increasing of activity serum glutamic oxalacetic transaminase and glutamic-pyruvic transaminase. Bactericidal and lysozymic activity of blood serum decreased. Activity of alkaline phosphatase increased.

The research directed on perfection of a cattle protein food system, taking into account its fractional structure, and also establishment of objective indicators of an estimation of forage protein nutrient density, have great value. It is established, that for young growth of cattle of 4-6 months of age the optimum parity of decomposable and un-decomposable protein in rations corresponds to size 68:32, allowed to raise digestibility of nutrients on 3-4%, nitrogen adjournment in an organism of animals on 10% and daily average a gain on 4% in comparison with parity 80:20. The optimum parity of fractional structure of protein makes positive impact on oxidation-reduction processes in organism to what testifies morphological-biochemical structure of blood. Thus concentration of crude protein raises on 1,7%, urea quantity decreases on 23%. The least cost price of a gain has appeared in group with a parity of decomposable and un-decomposable protein in rations 68:32, or it is better on 4,4% than an indicator of group with a parity 80:20%

Nowadays in connection with an interdiction for antibiotics use in animal feeding it is very actual to work out and apply new forms of probiotic preparations which should be as ecologically safe and harmless both to people and animal products. Probiotics make it possible to improve the digestibility of nutritive substances of forages, normalize metabolism, enrich with biologically active substances that promotes the increasing of their productivity. In the Republic of Belarus the probiotics are produced in the obviously insufficient quantity that creates problems of young stock livability. Influence of application of Akozil and Sublicin probiotics in diets of suckling calves on biochemical parameters of blood serum was analysed. It was stated that use of the analysed probiotics made it possible to decrease the level of urea and total cholesterol, to increase of the total protein content in blood serum of the experimental calves. There was noted the increasing of glucose level in blood serum of calves fed with Akozil. There was marked the tendency of more optimal level of calcium and phosphorus in calves having Sublicin in their diets. The obtained results testified the normalization of metabolic processes taking place in calves which were fed by the mentioned above probiotics