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Effects of Suaeda asparagoides M∧IQ extracts on mice ileal motility
2006
Song, J.C. (Kyungpook National University, Daegu, Republic of Korea) | Park, C.H. (Kyungpook National University, Daegu, Republic of Korea) | Kim, H.T. (Kyungpook National University, Daegu, Republic of Korea) | Endale, Mehari (Kyungpook National University, Daegu, Republic of Korea) | Rhee, M.H. (Kyungpook National University, Daegu, Republic of Korea) | Park, S.C. (Kyungpook National University, Daegu, Republic of Korea) | Kim, K.S. (Kyungpook National University, Daegu, Republic of Korea) | Kim, T.W. (Kyungpook National University, Daegu, Republic of Korea), E-mail: twkim@mail.knu.ac.kr
Suaeda (S.) asparagoides M∧IQ, one of the halophyte groups, has been used as a folk remedy for digestive disturbances in Korea. However, its pharmacological activity on gastrointestinal motility has not been reported yet. In this study, the effects of this halophyte extracts with various solvent fractions (ethanol, hexane, chloroform, ethyl acetate, butanol, and water) on mice ileal spontaneous motility was examined. All solvent fractions at the concentration of 100 ㎍/ml showed inhibitory actions on spontaneous motility of ileum with the potency order of water greater-than 70% ethanol greater-than hexane much greater-than chloroform greater-than or equal to butanol greater-than or equal to ethyl acetate, respectively.
Show more [+] Less [-]Effect of transmural stimulation to motility on isolated gastric smooth muscle
1999
Kim, J.H. (Gyeongsang National University, Chinju (Korea Republic). College of Veterinary Medicine and Institute of Animal Medicine) | Shim, C.S. (Gyeongnam Livestock Promotion institute, Chinju (Korea Republic). Eastern Branch) | Hong, Y.G. | Gyeongsang National University, Chinju (Korea Republic). Department of Biochemistry, College of Natural Science)
To elucidate the action of the cholinergic and adrenergic nerve on isolated gastric fundus smooth muscle of rabbit, the effects of electrical transmural stimulation were investigated in the presence of atropine, cholinergic receptor blocker; phentolamine, nonselective alpha-adrenergic receptor blocker; propranolol, nonselective beta-adrenergic receptor blocker and L-arginine from the isometric contraction of physiological recording system. 1. The contractile response induced by electrical transmural stimulation was increased as the frequency(1~32Hz)-dependent manner on the isolated gastric fundus smooth muscle. 2. The contractile response induced by electrical transmural stimulation was markedly inhibited by the pretreatment of atropine(1 microM). 3. The contractile response induced by electrical transmural stimulation was inhibited by the pretreatment of phentolamine(1 microM). 4. The relaxative response induced by electrical transmural stimulation on presence of atropine (1 microM) was inhibited by the pretreatment of propranolol(1 microM). 5. The relaxative responses on precontraction induced by histamine(10 microM) with guanethidine (50 microM) and atropine(1 microM) by electrical transmural stimulation were incresed by L-arginine(1mM). These fingings suggest that it was the exciatory action of cholinergic and alpha-adrenergic nerve, and the inhibitory action of beta-adrenergic nerve and nonadrenergic noncholinergic nerve on the isolated gastric fundus smooth muscle of rabbit.
Show more [+] Less [-]Actions of acetylcholine, norepinephrine, histamine and prostaglandin F2alpha on motility of pig oviductal isthmic smooth muscle
1994
Rho, G.J. | Kim, J.H. | Choe, S.Y. (Gyeongsang National University, Chinju (Korea Republic). College of Veterinary Medicine) | Park, S.E. (Gyeongnam Veterinary Medicine, Masan (Korea Republic). Central Branch) | Shim, C.S. (Gyeongnam Veterinary Medicine, Yangsan (Korea Republic). Eastern Branch)
