In the conditions of the Republic of Belarus there were presented the results of a veterinary and sanitary assessment and bacteriological investigation of sheep slaughter products, which showed meat serviceability for consumption after application of Triclafen suspension. Application Triclafen suspension did not render negative influence on an organism of animals. It was proved by organoleptic and laboratory research of meat of slaughter animals of experimental and control groups. The meat obtained from healthy sheep which were administrated the suspension in accordance with microbiological indicators proved to be of good quality and corresponded to the established norms (Sanitary regulations and standards 11 - 63 Republic of Belarus 98): it had the general bacterial content within admissible limits and did not contain agents of anthropozoonosts, alimentary toxicosis and toxinfections and it can be sold without any restrictions.

In the conditions of the Republic of Belarus there were studied the anthelminthic properties of preparative forms of elecampane (Inula helenium) (herbal infusion, tincture, liquid and dry extracts). Research results showed that the analyzed preparative forms in the administrated doses possesed high therapeutic efficiency against strongyloidosis and strongylatosis of gastroenteric path of sheep. Thus, according to results of research it was established, that the highest therapeutic effect rendered herbal infusion of elecampane in a dose of 6 ml/kg live weight once a day three days continuously; and the antiparasitic efficiency was 60%. Application of elecampane tincture in a dose of 1 ml/kg live weight once and 0,5 ml/kg of live weight twice rendered the 100% therapeutic effect. Administration of a liquid extract of elecampane in a dose of 0,2 ml/kg live of weight once and 0,1 ml/kg of live weight twice rendered 100% therapeutic effect. Application of elecampane dry extract in a dose of 30 mg/kg of live weight once and 25 mg/kg of live weight twice rendered 100% therapeutic effect.

In the conditions of the Republic of Belarus there were determined the parameters of acute and subacute toxicological characteristics of the developed in the Vitebsk State Academy of Veterinary Medicine anthelmintic preparations of durable action Febolvetum-О for control of sheep strongylatosis and Febolvetum for control of strongylatosis of cattle young stock. Data on determination of toxicological parameters of the prolonged action bolus were presented. Research results showed that the preparations did not render negative influence on laboratory animals (white mice). According to the parameters of acute oral toxicity the Febolvetum was qualify as the third hazard class. In accordance with the results of study of subacute toxicity parameters of the preparations, it was concluded, that in the conditions of free feeding of Febolvetum boluse in combination with forages in course of 30 days in doses of 200 mg/kg; 150 mg/kg; 100 mg/kg of body weight in animals there were found no signs of intoxication; there were not stated any is not fixed deviations in physiological state; and were stated no mice death.

Results of serological examinations of blood serum of sheep on revelation of virus respiratory infections (parainfluenza-3, adenovirus and respiratory syncytial) realized in the conditions of the Kyrgyz Republic were presented. Research results showed that in farm and peasant farm holdings of all studied districts of the Kyrgyz Republic of three types of pneumo viral infections simultaneously give high levels of antibody titers in relation to parainfluenza-3 – 1:128, adenovirus – 1:32, respiratory syncytial infection – 1:16. In some districts sheep population was diseased only by parainfluenzal infection in relation with titer of specific antibodies 1:256

Studying of topical-product-induced irritation properties of pharmaceutical forms elecampane (Inula helenium) (herbal infusion, tincture, liquid and dry extracts) on skin integuments and conjunctiva of experimental animals (Guinea pigs (Cavia porcellus), rabbits (Oryctolagus), sheep and piglets). Research results showed that the preparative forms of elecampane had poorly expressed irritating properties after application on the skin of animals, as well as weak irritating action with the exception of the native forms of tincture and liquid extract of eye conjunctiva, that proved their total low toxic effect. Topical-product-induced irritation effect of herbal infusion (1:10), tincture and liquid extract in constitution (40 % concentration) and suspension of dry extract in strength of 10%, 15%, and 20% after the single application on skin could be referred to the I class – absence of irritating action. Topical-product-induced irritation effect of herbal infusion and liquid extract in native form (70% concentration) could be referred to the II class – light irritating action. Irritating activity of herbal infusion of eye conjunctiva was evaluated as light, as it was insignificant and short. Irritating action of suspended matter of dry extract in strength of 10%, 15%, and 20% was estimated as a limited one, which disappeared in 24 hours. Irritating action of tincture and liquid extract in constitution (40 % concentration) was evaluated as a high-grade one, which did not disappear in 24 hours. Irritating action of tincture and liquid extract in native form (70 % concentration) was evaluated as a pronounced one, which did not disappear for than 24 hours

Serological properties of leptospirae bacteria grown on differential nutritive media were studied by the example of sheep in the conditions of the Republic of Belarus. In the experiment there were used 6 pathogenic industrial leptospirae stock: Leptospira pomona VGNKI-6; Leptospira tarassovi VGNKI-4; Leptospira grippothyphosa VGNKI-1; Leptospira icterrohaemorragia VGNKI-2; Leptospira conicola VGNKI-3; Leptospira hardjo VGNKI-5. The results showed a serological difference of leptospirae grown on conventional and experimental media derived from ram's blood.

On the basis of analysis of literary sources and realized studies there was realized an evaluation of the degree of losses caused by ruminant monieziasis in the conditions of modern agricultural production in the Republic of Belarus; the strategy of medical and preventive measures was presented. In course of studies there were analyzed sheep and cattle of different classes bred in farm holding of Belarus and imported from abroad, as well as different anthelmintic agents. Studying of antihelminthefficiency was tested on lambs with body weight 20 kg. Lambs were infested with moniezia (Moniezia expansa). Analysis of anthelmintic agent Alverm efficiency was realized by the example on infested heifers. Albazen was administrated once in dose of 0,8 mg/1 kg. Prazikvantel was administrated once in dose of 5,0 mg/1kg. Alverm was administrated once in dose of 80,0 mg/1 kg. Research results showed 100% extencefficiency and intencefficiency of albazen and prazikvantel. Alverm administrated once in dose of 80,0 mg/1 kg gly had 100 % 100 % extencefficiency and intencefficiency

Research results showed that in the conditions of correct organization and application of technological methods of livestock breeding and feeding it was possible to achieve high livability rate of sheep and lambs up to 90%. Also it was possible to get a substantial break of infection chain of many sheep diseases (especially those which had a respiratory nature). Research results showed that simultaneous application of convalescent-phase serum against sheep acute respiratory diseases, as well as Nitox 200 and Invamek for treatment of sheep and especially 2-3 month old lambs with respiratory infectious diseases promoted the recovery of 80-100% of animals.

In the conditions of the Republic of Belarus there was studied the nonspecific resistance of lambs of Latvian Black Face breed during the colostrum and milk fed period of their growth development. In course of the experiment there were used 10 newborn lambs. Analysis of resistance was realized in accordance with a scheme: before colostral milk sucking; in 6, 12, 24 hours; in 3, 7, 14, 21 days; in 1, 2 and 3 months after birth. In lambs during the colostrum and milk fed period of growth there were marked two critical periods, which were characterized by low indicators of resistance: before colostral milk uptake and at 7-21 day-old age. Increasing of leukocytes, bactericidal, lysozymic activity of blood serum, phagocytal activity of leukocytes, crude protein and antibodies in the first days of lamb life took place due to their entrance in blood with colostral milk, just because at this time the intestines wall possessed ability to transit in native condition the antibodies, enzymes, and leukocytes. At 7-21 day-old age in connection with reduction of these factors quantity of in colostral milk, and also due to reduction of intestines capacity, their was stated that their entrance in blood of newborn lambs decreased, but at 3 month old age of lambs there were stated to form internal protective factors of resistance because of which their quantity in blood started to increase.

Evaluation of a quantity and phagocyte activity of leucocytes, immunoglobulins, T- and B-lymphocytes in blood serum of sheep in the process of stimulation of central nervous system with caffeine sodiobenzoate for the increasing of nonspecific animal resistance was realized in the conditions of the Republic of Belarus. Romanov yeld ewes were divided into two groups. Experimental sheep were entered caffeine sodiobenzoate intramuscularly in dose 0,012 g/kg of live weight twice a day with 6 hours interval. Controlled group of sheep were entered physiological salt solution in accordance with the same scheme. Blood samples were taken before preparation entering and after 1, 3, 6, 12 and 24 hours of test beginning. Immunoglobulin concentration in blood serum was estimated by electrophoresis method in polyacrylamide gel. Quantity of T- and B- lymphocytes was estimated by active rosette test. Phagocyte activity of leucocytes was estimated with application of germ culture St. albus. Leucocytes number was accounted in Gorjaev's chamber. Research results showed that under conditions of central nervous system stimulation by caffeine sodiobenzoate there was stated the increasing of nonspecific resistance. It was proved by the increasing of the total number and phagocytic activity of leukocytes, immunoglobulins (IgG, IgA and IgM), T- and B- lymphocytes