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Anthelmintic activity of the macrocyclic lactone F28249-alpha in sheep.
1990
Shoop W.L. | Egerton J.R. | Eary C.H. | Suhayda D.
The macrolytic lactone F28249-alpha was titrated in experimentally infected sheep and found to be highly effective against most of the common gastrointestinal nematodes as a single oral dose, given at a rate of 0.025, 0.05, or 0.1 mg/kg. Specifically, maximal activity was evident at even the lowest dosage against adult Haemonchus contortus, Ostertagia circumcinta, Trichostrongylus axei, and T colubriformis and L4 O circumcinta. Activity against Oesophagostomum columbianum was also high at all dosages, with a calculated ED95 of 0.029 mg/kg. Cooperia curticei was eliminated at 0.1 mg/kg, but control was erratic at the lower dosages. The greatest weakness of this compound was its activity against C oncophora. The activity against this parasite was weak (<less than or equal to 85%) at all dosages, and the dosage-response curve was flat, suggesting dosages substantially higher than those given would be necessary for high-order control of this species.
Show more [+] Less [-]Deconvolution study of the absorption rate and disposition kinetic values of lindane in sheep.
1990
Dagorn M. | Guillot P. | Sanders P. | Laurentie M. | Toutain P.L.
Absorption rate and plasma and fat disposition of lindane after various lindane percutaneous treatments in shorn and unshorn sheep were investigated. To analyze data with a deconvolution method, IV administration was performed to determine the basic pharmacokinetic values of lindane in sheep. After IV administration, the steady state volume of distribution was very high (8.07 +/- 3.60 L/kg of body weight), and the mean residence time was long (28.1 +/- 11.7 hours). Deconvolution analysis indicated that lindane absorption was continuous until 33 to 41 days after spraying with a 0.025% lindane solution. Total amount of absorbed lindane in shorn (15,171 +/- 4,463 microgram/kg) sheep was about twice that in unshorn (7,615 +/- 3,128 microgram/kg) sheep; from deconvolution analysis, it was calculated that the time required for 50% of the available dose to be absorbed was between 115 and 179 hours. After percutaneous lindane administration, the fat concentration was compared with the available lindane dose. The apparent half-life of lindane elimination in fat was 225 +/- 47.4 hours, which is similar to the value calculated for the absorption rate constant. By comparing fat and plasma concentrations, it was calculated that for a mean plasma concentration of 5 ng/ml, the fat lindane concentration was 1.65 +/- 0.87 microgram/g (ie, lower than the generally accepted tolerance level of 2 microgram/g).
Show more [+] Less [-]Infectivity, reproductive capacity and distribution of Trichinella spiralis and T. pseudospiralis larvae in experimentally infected sheep
1990
Alkarmi, T. (Kuwait Univ.) | Behbehani, K. | Abdou, S. | Ooi, H.K.
Effect of orally administrated fluids in artificially dehydrated ruminant
1990
Kang, D.M. | Yang, I.S. | Lee, I.S. (Seoul National University, Suwon (Korea Republic). College of Veterinary Medicine)
Osmotic fragility of erythrocyte in cattle, sheep and goats
1990
Min, B.M. | Lee, B.W. (Chonnam National University, Kwangju (Korea Republic). College of Agriculture)
Seasonal changes in pasture populations of infective larvae of gastrointestinal nematodes of sheep
1990
Suh, G.H. (National Animal Breeding Institute, Namwon (Korea Republic). Namwon Branch) | Lee, C.G. | Park, Y.J. | Lee, C.Y. (Chonnam National University, Kwangju (Korea Republic). College of Veterinary Medicine)