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Pharmacokinetics, effects on renal function, and potentiation of atracurium-induced neuromuscular blockade after administration of a high dose of gentamicin in isoflurane-anesthetized dogs.
1996
Martinez E.A. | Mealey K.L. | Wooldridge A.A. | Mercer D.E. | Cooper J. | Slater M.R. | Hartsfield S.M.
Pharmacokinetic model for cefazolin distribution during total hip arthroplasty in dogs.
1996
Marcellin Little D.J. | Papich M.G. | Richardson D.C. | DeYoung D.J.
Pharmacologic effects and detection methods of methylated analogs of fentanyl in horses.
1989
Weckman T.J. | Tai C.L. | Woods W.E. | Tai H.H. | Blake J.W. | Tobin T.
Pharmacologic effects of alpha-methylfentanyl and 3-methylfentanyl, analogs of fentanyl, were investigated in mares. The ability of an 125I-labeled fentanyl radioimmunoassay (125I-RIA) to detect these methylated fentanyl analogs in individual and pooled urine samples from horses was evaluated. Also, the ability of 7 fentanyl antibodies to react with fentanyl and fentanyl derivatives (sufentanil, alfentanil, and carfentanil) was investigated. Mares were studied in a locomotor test to determine the amount of stimulation methylated fentanyl analogs might induce. Two mares each were given alpha-methylfentanyl at 1, 2, 4, 8, or 13 microgram/kg of body weight, IV, or 3-methylfentanyl at 0.4, 0.7, or 1 microgram/kg IV. The cross-reactivity of sufentanil, alfentanil, carfentanil, alpha-methylfentanyl, and 3-methylfentanyl with 7 fentanyl antibodies was studied, using the 125I-RIA. All fentanyl analogs, with the exception of alfentanil, cross-reacted well with a C1 antibody raised to fentanyl. Less satisfactory cross-reactivity was determined with 6 other antibodies raised to fentanyl derivatives. When the C1 antibody was combined with an iodinated analog to fentanyl, good detectability of alpha-methylfentanyl and 3-methylfentanyl, in terms of fentanyl equivalents, was obtained from urine samples of dosed mares. The ability of the 125I-RIA to detect methylated fentanyl analogs in forensic urine samples pooled in groups of up to 20 samples was evaluated. When these methylated analogs were administered to mares in doses that induced measurable locomotor stimulation, the analog's presence was readily detected in individual or pooled samples.
Show more [+] Less [-]Effect of probenecid administration on cephapirin pharmacokinetics and concentrations in mares.
1989
Juzwiak J.S. | Brown M.P. | Gronwall R. | Houston A.E.
Pharmacokinetics and bioavailability of ceftriaxone administered intravenously and intramuscularly to calves.
1988
Soback S. | Ziv G.
Pharmacokinetics of amikacin in pony foals after a single intramuscular injection.
1986
Brown M.P. | Gronwall R.R. | Martinez D.S. | Beal C.
Thiacetarsamide in dogs: disposition kinetics and correlations with selected indocyanine green kinetic values.
1986
Holmes R.A. | Wilson R.C. | McCall J.W.
Pharmacokinetics of digoxin in sheep: limitations of theuse of biological half-life for interspecies extrapolation.
1985
Dix L.P. | Bai S.A. | Rogers R.A. | Anderson D.L.
Disposition and excretion of 6-methoxy-2-naphthylacetic acid, the active metabolite of nabumetone in horses.
1996
Soma L.R. | Uboh C.E. | Rudy J.A. | Smith M.S.
Pharmacokinetics of heparin and its pharmacodynamic effect on plasma lipoprotein lipase activity and coagulation in healthy horses.
1995
McCann M.E. | Watson T.D.G. | Boudinot F.D. | Moore J.N.
We evaluated the pharmacokinetics of IV administered sodium heparin and the pharmacodynamic effect of heparin on lipoprotein lipase (LPL) activity Horses were allotted to 3 groups. Plasma samples were obtained from each horse before and at various times for 6 hours after heparin administration for determination of heparin concentration, LPL activity, and activated partial thromboplastin time (APTT). The disposition of heparin was dose dependent. The area under the plasma heparin concentration vs time curve (AUC) increased more than proportionally with dose, indicating that heparin elimination was nonlinear. Total clearance of heparin was similar after the 40 and 80 IU/kg of body weight dosages, averaging 0.45 and 0.36 IU/kg/min, respectively. However, after administration of the 120 IU/kg dose, clearance was significantly less than that after the 40 IU/kg dose. The half-life of heparin averaged 53, 70, and 136 minutes after 40, 80, and 120 IU/kg, respectively, with significant differences observed between the low and high doses. In contrast to heparin, the area under the plasma concentration vs time curve for LPL activity increased less than proportionally with dose. Maximal LPL activity observed was independent of dose, averaging 4.8 micromole of free fatty acids/ml/h. The APTT was significantly prolonged for 120 minutes after administration of the 40 IU/kg dose. Correlation coefficients for LPL activity vs either plasma heparin concentration or APTT were less than 0.7, indicating that neither laboratory measure can be used to accurately predict plasma LPL activity.
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