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Острая и подострая токсичность препаративных форм девясила высокого
2009
Gurskaya, I.V. | Tolkach, N.G. | Gurskij, P.D., Vitebsk State Academy of Veterinary Medicine (Belarus) | Buzuk, G.N., Vitebsk State Medical Univ. (Belarus)
Investigation of acute and subacute toxicity of formulations of elecampane (Inula helenium) (herbal infusion, tincture, liquid and dry extracts) by the example of experimental white mice of both sexes ( body weight - 18-20 g) and white rats (body weight - 180-200 g) was realized in the conditions of the Republic of Belarus. In course of studies there were analyzed behavior (excitation or depression), physical activity, habitus, appetite, degree of reaction revelation to exogenous irritants, presence of shivering, cramps, paresis, comatose state, time and character of intoxication, dates of animal death). Results of the toxicological experiments showed that the developed preparative forms of elecampane could be referred to the substance hazard category 4, i.e. low-hazardous substances (lethal dose (LD) sub(50) more than 5000 mg/kg live weight). Median lethal dose of tincture was 14043 mg/kg for mice and 12684 mg/kg for rats. Median lethal dose of liquid extract was 13230 mg/kg for mice and 12285 mg/kg for rats
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