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Evaluation of hemorheologic variables as implications for exercise-induced pulmonary hemorrhage in racing Thoroughbreds.
1992
McClay C.B. | Weiss D.J. | Smith C.M. II | Gordon B.
Hematologic and rheologic changes were examined in 49 Thoroughbreds before and after competitive racing. Mean postrace values for RBC count, hemoglobin concentration, and PCV increased by 58 to 61%, whereas blood viscosity increased 2 to 3 times. Postrace echinocyte numbers were 162% greater than prerace values. Smaller, but statistically significant, changes were found for mean corpuscular hemoglobin concentration, red cell distribution width, plasma total protein concentration, total WBC count, neutrophil count, and lymphocyte count. Variables measured did not predict whether a horse was a bleeder not treated with furosemide, a bleeder treated with furosemide, or a nonbleeder.
Show more [+] Less [-]Systemic and pulmonary antibody response of calves to Pasteurella haemolytica after intrapulmonary inoculation.
1992
McBride J.W. | Corstvet R.E. | Paulsen D.B. | McClure J.R. | Enright F.M.
Systemic and pulmonary antibody responses of calves to Pasteurella haemolytica were evaluated by measuring immunoglobulin production in blood for 9 days and in pulmonary lavage fluid for 7 days after intrapulmonary inoculation. Clinical signs, pulmonary lesions, pulmonary and systemic inflammatory response, and amount of antigen in lavage fluid were used to evaluate the response of calves to challenge with P haemolytica. The pulmonary response consisted of production of IgG, IgE, and IgM antibodies to P haemolytica antigens and a 17- to 68-fold increase of cells in lavage fluid 8 hours after inoculation, with a gradual decrease toward normal. Antibodies of the IgM isotype to P haemolytica were demonstrated as early as 8 hours through 7 days after inoculation in 3 of 3 calves. Of the anti-P haemolytica isotypes, IgM was found in the highest concentration. In all of the inoculated calves, IgE was found 1 to 2 days after inoculation, and IgG was found in 2 of 3 inoculated calves from day 1 through 7 after inoculation. Detection of IgG correlated with smaller pulmonary lesions. Immunoglobulin A was not detected in lavage fluid. Serum was evaluated for IgG and IgM antibody response to P haemolytica. Specific IgM was detectable 5 days after inoculation, and IgG was detectable 7 days after inoculation. Pasteurella haemolytica antigens were not detected in serum or plasma. A transient increase in neutrophil count was found 8 hours after inoculation, with return to baseline values by 24 hours after inoculation. Antigen was detected in lavage fluid by use of monoclonal antibodies against selected P haemolytica capsular antigen, outer membrane antigens, and leukotoxin in all inoculated calves 8 hours after inoculation. The monoclonal antibody specific for P haemolytica capsule provided the best detection of antigen. The other monoclonal antibodies detected antigen, but were less consistent.
Show more [+] Less [-]Detection of equine immunoglobulin-secreting cells by a plaque assay
1992
Goto, I. (Hokkaido Univ., Sapporo (Japan). Faculty of Veterinary Medicine) | Kamada, M. | Inaba, M. | Maede, Y.
Studies on the contact infection of canine demodicosis (1)
1992
Lee, C.Y. | Lee, C.H. | Seo, G.W. (Chonnam National University, Kwangju (Korea Republic). College of Veterinary Medicine)
Clinico-pathological studies on the experimental lead poisoning in goats-(1)-Clinical observations(clinical, hematological and urinary findings)
1992
Kwon, O.D. | Lee, J.M. | Chae, J.S. (Chonbuk Nat'l Univ., Chonju (Korea Republic). Coll. of Veterinary Medicine) | Lee, H.B. (Kyungpook Nat'l Univ., Taegu (Korea Republic). Coll. of Veterinary Medicine)