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Chemopreventive effects of garlic and mugwort mixture extract on Helicobacter pylori-associated mouse gastric carcinogenesis
2014
Youm, S.Y., Chungbuk National University, Cheongju, Republic of Korea | Kim, T.W., Chungbuk National University, Cheongju, Republic of Korea | Shin, S.K., Chungbuk National University, Cheongju, Republic of Korea | Jeong, H.S., Chungbuk National University, Cheongju, Republic of Korea | Kang, J.K., Chungbuk National University, Cheongju, Republic of Korea | Kim, T.M., Chungbuk National University, Cheongju, Republic of Korea | Kim, K.H., Cosan Institute of Water Science, Seoul, Republic of Korea | Ahn, B.W., Chungbuk National University, Cheongju, Republic of Korea
Garlic and mugwort have long been used in traditional medicine to prevent various diseases. Several in vitro studies have reported protective efficacies of garlic and mugwort in cases of gastric cancer. In the present study, we investigated the cancer preventive effects of garlic and mugwort mixture extract (GME) in a Helicobacter (H.) pylori-associated gastric carcinogenesis mouse model. To induce gastric cancer, C57BL/6 mice were treated with N-methyl-N-nitrosourea and H. pylori. Various concentrations of GME (0, 100, 500, and 1,000 ppm) were then fed to the mice for 38 weeks, after which the tumor tissues were examined for histopathology, mucin histochemistry and ¥�-catenin. The incidence of gastric tumors was significantly lower in the highest dose GME-treated mice (46.7%) than control mice (85.7%) (p 0.05). The multiplicity and size of tumors were also significantly reduced by GME feeding in a dose-dependent manner (p 0.01). Furthermore, GME suppressed the H. pylori-associated chronic inflammation measured by histologic grading of H. pylori density, chronic gastritis, glandular atrophy and intestinal metaplasia in non-tumorous gastric mucosae. Our data suggest that GME suppresses gastric tumorigenesis via suppression of H. pylori-associated chronic inflammation.
Show more [+] Less [-]Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
2014
Yu, E.A., Tongyeong National Quarantine Station, Ministry of Health & Welfare, Tongyeong, Republic of Korea | Cha, C.N., Gyeongsang National University, Jinju, Republic of Korea | Park, E.K., (Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan, Republic of Korea | Yoo, C.Y., Department of Computer Information, Gyeongnam Provincial Namhae College, Namhae, Republic of Korea | Kim, S., Gyeongsang National University, Jinju, Republic of Korea | Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea
This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20§¡/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4 ¡¿MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
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