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Somatosensory-evoked and spinal cord-evoked potentials in response to pudendal and tibial stimulation in cats
1989
Sims, M.H. | Selcer, R.R.
Somatosensory-evoked potentials (SEP) and spinal cord-evoked potentials (SCEP) were recorded in clinically normal adult cats in response to electrical stimulation of pudendal and tibial nerves to provide normative data that can be used in a clinical evaluation of pudendal nerve function in cats after sacral or sacrococcygeal luxations or fractures. Responses to tibial nerve stimulation were included in the study as an internal control because it is usually not involved in these types of injuries and because its SEP and SCEP are easily recorded. Evoked potentials were characterized by the latencies (ms) of positive (P or p) and negative (N or n) peaks. The SEP resulting from percutaneous pudendal nerve stimulation consisted of a prominent P-N-P potential in the 30- to 80-ms range. The pudendal SCEP was not successfully recorded because of large muscle artifacts evoked from the sacral area. The tibial SEP was similar to the pudendal SEP, except that the prominent P-N-P series in the 35- to 81-ms range was preceded by a smaller p-n-p-n sequence in the 7- to 23-ms range. The tibial SCEP consisted of a P-N-P series in the 2- to 4-ms range.
Show more [+] Less [-]Characterization of osteosarcoma cells from two sibling large-breed dogs
1989
Norrdin, R.W. | Powers, B.E. | Torgersen, J.L. | Smith, R.E. | Withrow, S.J.
Neoplastic cells were isolated from 2 sibling Great Dane/Labrador Retriever mixed-breed dogs in which telangiectatic type osteosarcomas arose concurrently. Cells from various sites in the same osteosarcoma appeared similar in culture, but there were differences between the 2 osteosarcomas in growth characteristics and appearance of cells. Cells from 1 osteosarcoma had a small, but significant (P less than 0.05), cyclic adenosine monophosphate response to parathyroid hormone stimulation, indicating a low order of osteoblastic differentiation. Cells from the other osteosarcoma had no response to parathyroid hormone stimulation. Cells from both osteosarcomas and a concentrated cell-free filtrate from the osteosarcoma with osteoblastic differentiation were injected into nude mice, but osteosarcomas were not induced. Results of ultrastructural examination of osteosarcoma samples for viral particles were negative and supernatant fluids from cultured cells were considered negative for viral reverse transcriptase activity.
Show more [+] Less [-]Neochondrogenesis in free intra-articular, periosteal, and perichondrial autografts in horses
1989
Vachon, A. | McIlwraith, C.W. | Trotter, G.W. | Norrdin, R.W. | Powers, B.E.
Periosteal autografts were obtained from the medial aspect of the proximal portion of the tibia, and perichondrial autografts were obtained from the sternum. Using arthroscopic visualization, each autograft was placed as a loose body into 1 tarsocrural joint in 6 young horses (2 to 4 years old). Horses were hand-walked daily, starting the day after surgery, for a total of 6 h/wk for 8 weeks. Eight weeks after autograft implantation, radiographs were taken of each tarsocrural joint and were interpreted with regard to mineralization in the transplanted autografts. Autografts were then surgically removed, and examined macroscopically and microscopically for viability, size, and production of chondroid tissue. All autografts appeared viable and most had evidence of growth. Longest-by-shortest axis value, cross-sectional area, and perimeter were greater in perichondrial autografts than in their periosteal counterparts in 3 horses, but the difference was not significant. Neochondrogenesis was observed in 5 of 6 periosteal grafts and in 1 of 6 perichondrial grafts. Futhermore, the amount of chondroid tissue produced in periosteal autografts was significantly (P less than 0.05) greater than that produced in the 1 perichondrial graft. The chondroid tissue produced by periosteal autografts had morphologic and matrical staining properties similar to those of hyaline cartilage.
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