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Detection of native interferon-γ in nyala (Tragelaphus angasii): Towards diagnosing tuberculosis
2019
Roux, Lezaan(University of Pretoria Faculty of Veterinary Science Department of Veterinary Tropical Diseases, Bovine Tuberculosis and Brucellosis Research Programme) | McCall, Alicia J.(Veterinary Services Department of Agriculture and Rural Development) | Michel, Anita L.(University of Pretoria Faculty of Veterinary Science Department of Veterinary Tropical Diseases, Bovine Tuberculosis and Brucellosis Research Programme)
Mycobacterium bovis is the main cause of tuberculosis in wildlife. In South Africa, African buffaloes (Syncerus caffer) are a wildlife maintenance host while a number of other species are considered spillover hosts. Nyala (Tragelaphus angasii), a large antelope species from Southern Africa, is frequently traded and can be infected with M. bovis. Interferon gamma (IFN-γ) release assays that detect cell-mediated immune (CMI) responses to M. bovis infection have shown promise in elephants, rhinoceroses and buffaloes. The BOVIGAM® assay is a commercial IFN-γ release assay designed to detect tuberculosis in cattle and has been validated in buffaloes. We tested the suitability of the BOVIGAM® assay to detect native IFN-γ release in nyala. Blood samples collected from 17 nyalas were stimulated with different mitogens and IFN-γ release measured. We found that incubating whole blood with phorbol 12-myristate 13-acetate and calcium ionophore (PMA/CaI) resulted in the highest levels of IFN-y release. Samples stimulated with tuberculin purified protein derivatives of M. bovis (PPDb) and M. avium (PPDa) did not show significant IFN-γ production. An intradermal tuberculin test (IDT) and culture of tissues from 15 of the 17 culled nyala were also performed, which supported the findings of the BOVIGAM® assay, suggesting the potential value of this assay for the diagnosis of tuberculosis in nyala.
Show more [+] Less [-]Detection of native interferon-γ in nyala (Tragelaphus angasii): Towards diagnosing tuberculosis
2019
Roux, Lezaan(University of Pretoria Faculty of Veterinary Science Department of Veterinary Tropical Diseases, Bovine Tuberculosis and Brucellosis Research Programme) | McCall, Alicia J.(Veterinary Services Department of Agriculture and Rural Development) | Michel, Anita L.(University of Pretoria Faculty of Veterinary Science Department of Veterinary Tropical Diseases, Bovine Tuberculosis and Brucellosis Research Programme)
Mycobacterium bovis is the main cause of tuberculosis in wildlife. In South Africa, African buffaloes (Syncerus caffer) are a wildlife maintenance host while a number of other species are considered spillover hosts. Nyala (Tragelaphus angasii), a large antelope species from Southern Africa, is frequently traded and can be infected with M. bovis. Interferon gamma (IFN-γ) release assays that detect cell-mediated immune (CMI) responses to M. bovis infection have shown promise in elephants, rhinoceroses and buffaloes. The BOVIGAM® assay is a commercial IFN-γ release assay designed to detect tuberculosis in cattle and has been validated in buffaloes. We tested the suitability of the BOVIGAM® assay to detect native IFN-γ release in nyala. Blood samples collected from 17 nyalas were stimulated with different mitogens and IFN-γ release measured. We found that incubating whole blood with phorbol 12-myristate 13-acetate and calcium ionophore (PMA/CaI) resulted in the highest levels of IFN-y release. Samples stimulated with tuberculin purified protein derivatives of M. bovis (PPDb) and M. avium (PPDa) did not show significant IFN-γ production. An intradermal tuberculin test (IDT) and culture of tissues from 15 of the 17 culled nyala were also performed, which supported the findings of the BOVIGAM® assay, suggesting the potential value of this assay for the diagnosis of tuberculosis in nyala.
Show more [+] Less [-]The epidemiology of tuberculosis in free-ranging African buffalo (Syncerus caffer) in the Kruger National Park, South Africa
2001
De Vos, V. (South African National Parks, Skukuza (South Africa). Kruger National Park) | Bengis, R.G. | Kriek, N.P.J. | Michel, A. | Keet, D.F. | Raath, J.P. | Huchzermeyer, H.F.K.A.
A review of the infectious diseases of African wild ruminants
2001
Worthington, R.W. | Bigalke, R.D.
Tuberculosis in buffaloes (Syncerus caffer) in the Kruger National Park [South Africa] : Spread of the disease to other species
1996
Keet, D.F. (Kruger National Park, Skukuza (South Africa). State Veterinarian) | Kriek, N.P.J. | Penrith, M.-L. | Michel, A. | Huchzermeyer, H.
An outbreak of bovine tuberculosis in a free-living African buffalo (Syncerus caffer-Sparrman) population in the Kruger National Park [South Africa]: a preliminary report
1996
Bengis, R.G. (Department of Agriculture, Skukuza (South Africa). Directorate of Animal Health) | Kriek, N.P.J. | Keet, D.F. | Raath, J.P. | De Vos, V. | Huchzermeyer, H.F.A.K.
A preliminary investigation of tuberculosis and other diseases in African buffalo (Syncerus caffer) in Queen Elizabeth National Park, Uganda
Kalema-Zikusoka, G. | Bengis, R.G. | Michel, A.L. | Woodford, M.H.
Tuberculosis in kudus (Tragelaphus strepsiceros) in the Kruger National Park
2001
Keet, D.F. (State Veterinarian, Skukuza (South Africa)) | Kriek, N.P.J. | Bengis, R.G. | Michel, A.L.
Validity of intradermal tuberculin testing for the screening of bovine tuberculosis in Madagascar
2001
Quirin, R. | Rasolofo, V. | Andriambololona, R. | Ramboasolo, A. (Veterinary Services, Antananarivo (Madagascar)) | Rasolonavalona, T. | Raharisolo, C. | Rakotoaritahina, H. | Chanteau, S. | Boisier, P.
Tuberculosis, caused by Mycobacterium bovis, in a kudu (Tragelaphus strepsiceros) from a commercial game farm in the Malelane area of the Mpumalanga Province, South Africa
2001
Bengis, R.G. | Keet, D.F. (State Veterinarian, Skukuza (South Africa)) | Michel, A.L. | Kriek, N.P.J.