Determination of degree and relations between derangements of metabolic processes in calves with respiratory syndrome in the milking period was realized in the conditions of the Republic of Belarus. Research results showed that the calves with the respiratory syndrome had expressed metabolic processes disturbances, which were marked in the analyzed biochemical blood indexes (total protein; albumins; urea; creatinine; glucose; cholesterin; triglycerids; bilirubin; ALP; AAT; SGPT; calcium; phosphorous; magnesium; iron; manganese; cobalt; cuprum; zinc). In calves with respiratory syndrome there was noted the increased content of crude protein in blood serum (71,42 +/- 2,57 g/l P less than 0,05), low urea level (3,08 +/- mmol/l). There was the increased level of creatine (574,11 +/- 65,26 mkmol/l; P less than 0,01) and bilirubin (8,11 +/- 1,15 mkmol/l; P less than 0,05). Glucose concentration in blood of diseased calves was at below standard level (3,49 +/- 0,69 mmol/l). Glucose indexes varied and were changing during a day; and depended on muscular activity, intervals between feeding and hormonal regulation. Diseased calves had high cholesterol level in blood serum (4,07 +/- 0,34 mmol/l; P less than 0,05), which was stated in case of liver disease and hypothyroidism. Phosphor level was higher than the standard indexes of healthy calves (2,85 +/- 0,03 and 2,05 +/- 0,05, respectively). Content of magnesium, cobalt and zinc in blood of the diseased calves was lower than in healthy ones. Calves with respiratory pathology had protein, fat, hydro-carbonic and mineral metabolic processes

Investigation of acute and subchronic (chronic) toxicity of complexinates of trace elements in experiments with calves was realized in the conditions of the Republic of Belarus. The realized experiments were based on developed in Belarus veterinary preparations for the treatment and prevention of diseases connected with disorders of trace elements exchange containing chelate compounds of trace elements with sodium ethylene diamine acetate: Cuprovet (on the basis of CuNa); Cobalvet (on the basis of CoNa), Zinkovet (on the basis of ZnNa), and Feravet (on the basis of FeNa). There were the following indexes of ferrum in nephros - 55,3 +/- 2,26, in muscles - 134 +/- 26,6 mkg/g, and in liver - 565 +/- 35,5 mkg/g after administration of Feravet. There were the following index of zinc in nephros - 56,3 +/- 2,64, in muscles -25, 8 +/- 1,23 and in liver - 84,4 +/- 3,29 mkg/g after administration of Zinkovet. There were the following indexes of cuprum in nephros - 4,1 +/- 0,325, in muscles - 2,33 +/- 0,117, and in liver - 12,3 +/- 1,12 mkg/g after administration of Cuprovet. There were the following indexes of cobalt in nephros - 40,35 +/- 2,29, in muscles - 12,5 +/- 0,98, and in liver - 126,5 +/- 10,45 ng/g after administration of Cobalvet. Parameters of toxicity of all preparations were by the example of laboratory mice, rats and calves given. Content of trace elements in blood of calves in dynamics of the experiment was analyzed. There were determined parameters of acute toxicity of the analyzed preparations: they all could be referred to substance hazard category 4 (low-hazardous substances). The determined parameters of acute toxicity made it possible to recommend them for treatment and prophylaxis of microelementoses of cattle, as well as to use them as feed additives taking into consideration that defect action levels of the analysed preparations exceed the deficiency needs of cattle in case of their limited cumulation

Investigation of efficiency of electrochemically active solutions in complex therapy of calves with diseases of the digestive apparatus and respiratory organs was realized in the conditions of the Republic of Belarus. Calves diseased with dyspepsia and bronchopneumonia were chosen for investigation of gastrointestinal diseases and respiratory diseases. At the first stage there was studied the therapeutic efficacy of water solution of electrochemically active neutral anolyte and sodium hypochloride solution Akvamed for calves sick with dyspepsia. At the second stage there was analyzed the therapeutic efficacy of 0,04 % solution sodium hypochloride Akvamed for the treatment of bronchopneumonia of calves. Research results showed that inclusion into complex therapeutic regimen of calves of electrochemically active solutions promoted the reduction of disease duration and severity. Electrochemically active solutions had high biocidal activity and could be produced in large volumes, had practical safety, low price and acute therapeutic effect

Evaluation of antagonistic activity of strains of lactic and bifid bacteria, metabolite producers, as well as the treatment and prophylactic efficacy of Laktimet and Batsinil probiotics was realized in the conditions of the Republic of Belarus. In course of study there were estimated 29 strains of lactic acid bacillus of different kinds, 13 strains of bifid bacteria and 35 strains of bacillus (Bac. subtilis and Bac. pumilis). There were studied 3 strains of bifid bacteria: Bifidobacterium adolescentis MS-42; Bifidobacterium adolescentis BIM V-01; Bifidobacterium adolescentis BIM V-87; 2 strains of lactic acid bacillus: Lactococcus lactis subsp. Lactis BIM V-132, Lactococcus casei subsp. rhamnosus BIM V-189; and 6 strains of Bacillus subtilis. Research results showed that the main part of the studied strains had steady antagonistic activity to test-cultures of opportunistic pathogenic bacteria. Zone of growth delay of test-cultures of the main quantity of strains (from 54 up to 92%) was from 11 up to 30. Research results showed that application of cell-free probiotics Laktimet and Batsinil promoted the increasing of resistance by means of increasing or lowering of total protein, insignificant increasing of blood serum bactericidal activity and increasing of phagocytic activity of leukocytes on 7,3%

Studies of morphological and morphometrical particularities of rennet of newborn calves with different degree of antenatal hypotrophy were realized in the conditions of the Republic of Belarus. Scientific-and-production researches were spent in 2007 - 2008 on the basis of agricultural production co-operative Dembrovo (Shchuchinskij district, Grodno area, Belarus), agricultural production co-operative Okhovo (Pinsk district, Brest region, Belarus) and research laboratory of Grodno State Agrarian University (Belarus). For an estimation of morphofunctional maturities there were used 165 1-day old calves. Research results showed that in the studied calves the basic indexes of glanderous apparatus of rennet proved the different degree of morphofunctional immaturity. In calves with hypertrophy in the first days after birth there stated an active morphogenesis of all cytological components of rennet

Investigation of spreading of diseases of micronutrient deficiencies at cow breeding farms of Grodno district of the Republic of Belarus depending on the season and character of polymicroelementoses, as well as the determination of relations between polyhypomicroelementoses and state of new born calves were realized. Clinical investigation of 1350 milked and calf-bearing dry cows and biochemical analysis of 450 blood samples taken at nongrazing time (before cows pasture) and at pasture time were conducted. The following animal groups were selected: the first group – cows after calving; the second group – the cows of three month pregnancy; the third group – calf-bearing dry cows. The following groups were selected among calf-bearing dry cows in nongrazing and pasture time: clinically healthy cows, which had biochemical blood changes, showing development of subclinical polyhypomicroelementoses (n = 20); clinically healthy cows with blood indicators, standing in limits of physiological standards. Number of calves was considered after calving of cows of both groups. Body weight, realization of staying and sucking position, evidence of sucking reflex, and calves disposition to neonatal pathology were considered in the study. Research result showed that cow microelementoses were marked by the development of subclinical polyhypomicroelementoses. Among cow polyhypomicroelementoses there was noted the domination of states followed by lowering of zinc, cobalt and cuprum content. Polyhypomicroelementoses were developing both in winter housing season and in course of grazing season. Polyhypomicroelementoses involve cows of different physiological states and were spreading more intensively at cow dry period and after calving. Calves obtained from cows with polyhypomicroelementoses often had the state of hypotrophy and high incidence of dyspepsia at colostric period. Clinical and biochemical status of the analyzed calves was characterized by signs of intoxication and hepatic insufficiency

The physical and biological properties of a produced in the conditions of the Republic of Belarus nonspecific blood serum of animals according to an improve technology corresponded to all necessary standards. The prophylactic efficiency of nonspecific blood serum of animals was 80%, that was on 10% higher than serum of convalescents. Therapeutic effectiveness of nonspecific blood serum was 90%, that was on 8% higher than serum of convalescents

Determination of the positive aspects of application of a feed additive on the basis of sodium humate and malt sprouts fortified with oaky extract in diets of high-productive cows in dry period was realized in the conditions of the Republic of Belarus. Cows of black-and-white breed with average body weight 600 kg and milk-yield 6000-7000 kg were used in the experiment. Cows of experimental groups in addition to their main diet were fed with the resolved additive in doses 10-20 ml/100kg of live weight. Formula of humic additive with draft name Ehkolin-3 was developed on the basis of Ehkolin additive. Ehkolin additive in its composition contained the following compounds: organic substances; mineral substances; humic substances; melanoids; reducing agents; phenolic compounds; organic acids, and total nitrogen. Research results showed that application of the analyzed additive promoted the increasing enzyme activity in blood serum. Body weight of new born calves in experimental groups was higher than in control group. Symptoms of diseases of the digestive tract disappeared in 4-5 days in the experimental calves. Cows of the experimental groups had good colostral milk with density 1056 kg/mE3 and 55% of immunoglobulins. Impregnation capacity of in one experimental group was 50% after the first insemination, and only 33,3% and 20% in the control and the second experimental group, respectively

In course of realized in the conditions of the Republic of Belarus evaluation of growing intensity and level of meat productivity depending on cattle sex there was conducted the scientific and economic experiment by an example of two groups of white-and-black bull-calves and heifer calves. In the first growing period the animals of experimental groups were fed with milk substitute. At the stage of completion of growing and fattening the bulls and heifers of experimental groups obtained ration containing haylage, plus 2 kg of flattened grains and 2 kg mixed fodders. Results of linear and weight indexes analysis showed that in changes of exterior of bulls and heifers of black-and-white breed there was noted a certain regularities in their growth and development. The most intensive growth and development of analyzed young cattle was stated at age from 6 till 12 months. At the same time, bulls exceeded heifers according to the main exterior indexes. According to the visual evaluation of bulls and heifers there were determined the differences in constitutional type

Comparative effectiveness of application of SV-1 and SV-2 sorbents for preventive treatment of abomazoenterite of 1-2 month old calves was studied in the conditions of the Republic of Belarus. Research results showed that application of SV-1 and SV-2 sorbents rendered a positive influence on hematological and biochemical blood indexes, in particular, there was an increasing of hemoglobin level, albumins content, alkaline reserve, calcium and phosphorous in blood serum. They also rendered the stimulatory effect on natural resistance. The prophylactic effectiveness in experimental group was 100%, in a control one – 60%.