In India there is no present government policy to survey and evaluate adverse drug events (ADEs) / Pharmacovigilance programme in veterinary medicine. Therefore, essential information such as frequency, severity of treated animal ADRs and reliable data about frequent ADR-producing drugs remains unknown. The objective of the study is to assess and communicate risks and benefits in the market. Ultimately to educate the veterinarians and the stake holders on the safety and efficacy of veterinary drugs and biologicals. To this purpose, a 12 month pilot study based on WHO recommendations was conducted to monitor ADRs in the livestock treated by field veterinarian in the state of Tamil Nadu in India for frequently used drugs and common labeled signs. The present study warrants for the need for sustained veterinary pharmacovigilance programmers in livestock for timely ADR presenting drug reactions and drug safety improvement. 

We estimated the incidence of clinical mastitis (CM) and antimicrobial agent (AMA) usage for its treatment in an organized dairy farm over a period of six months. The incidence of mastitis at different stages of lactation was also quantified. The incidence of mastitis was higher in Sahiwal cows (9.52%) compared to crossbred cows (3.61%). Among different AMA usage, enrofloxacin (22%), ampicilin with cloxacillin (18.57%), gentamicin (18.29) and ceftriaxone (12.57%) drugs were most commonly used against CM cases. Penicillin group and their combinations (29.43%) was found to be the most commonly used AMA for CM followed by fluoroquinolone (22%), aminoglycosides groups (21.43%) and cephalosporins group (16.86%) of drugs. Tetracyclines (9.14%) and chloramphenicol (1.14%) were least choice as evidenced by less frequent usage. From the findings of the study it may be concluded that the incidence of mastitis was high in Sahiwal cows milked with machine milking system and mastitis animals needed an average of five days treatment for clinical cure. Further, â-lactam group of antimicrobial drugs were predominantly used in mastitis treatment, despite entry of new AMA in the market.

The  breeding  values  of  51  Sahiwal  sires  were estimated from the actual and predicted FL305DMY by applying four sire evaluation methods viz., least squares, simple regressed least squares, best linear unbiased prediction and derivative free restricted maximum likelihood. The derivative free restricted maximum likelihood method had lowest error variance for both actual and predicted first lactation 305-days milk yields and it was considered to be the most efficient method. The BLUP method was second efficient  followed by LSM and SRLS method.

An experiment was conducted to study the effect of dietary supplementation of calcium, carnitine, zinc and their combinations for 5 weeks in eighty adult crossbred cocks which were divided into eight treatment groups each consisting of ten cocks. Cocks were fed with treatment diets. The treatment groups consisted of control (T1), control + calcium 2 per cent (T2), control + carnitine 250 mg/kg (T3), control + zinc 100 mg/kg (T4), control + calcium 2 per cent + carnitine 250 mg/kg (T5), control + calcium 2 per cent + zinc 100 mg/kg (T6), control + carnitine 250 mg/kg + zinc 100 mg/kg (T7) and control + calcium 2 per cent + carnitine 250 mg/kg + zinc 100 mg/kg (T8). Semen volume revealed no significant difference between treatment groups during five weeks period. Overall sperm motility was significant (P<0.01) between treatment groups except between T4 and T5 groups. Overall sperm concentration was significantly (P<0.01) higher in all treatment groups compared to control. Inclusion of calcium, carnitine, zinc and their combinations had significantly (P<0.01) reduced the overall dead and abnormal of sperms when compared to the control group. The results revealed that inclusion of 2 per cent calcium, 250 mg/kg of carnitine, 100 mg/ kg of zinc and their combinations in feed improved the sperm motility and concentration in cross-bred cocks. 

Ten cattle with severe generalised skin lesions due to dermatophilosis were taken up for the study. Typical exudative dermatitis lesions with matting of hairs, thick scab formation and fissures on the skin were noticed in lower limbs, udder, perineum, inguinal region, axilla, neck and ears. Haematological analysis revealed anaemia and an increase in the absolute eosinophil count in affected animals. Serum biochemical estimations revealed hypoalbuminaemia, hyperglobulinaemia, a decrease in A/G ratio, increase in the blood urea nitrogen value and decrease in the zinc level in affected animals

An investigation among fifty each tribal and non-tribal dairy farmers in four dairy dominated development blocks of Cachar district of Assam revealed that, among tribal and non-tribal farmers attitude towards dairy farming, economic motivation and source of motivation for dairy communication were found to have favourable scores with positive and significant correlation with communication behaviour. Regression analysis revealed that source of motivation for dairy communication crucially influenced communication behaviour of dairy farmers. Further, there louid significant difference between the tribal and non-tribal dairy farmers indicating sensitive strategies for dairy development in the area involving the veterinarians. 

Swiss cheese samples collected aseptically from private dairies were analysed for the presence of Penicillium citrinum and for the efficacy of antimycotic agents against P.enicillium citrinum. The spore suspension of Penicillium citrinumand antimycotic agents like pimaricin and potassium sorbate at specified concentrations were added to cheese and stored at 250 C for 21 days. The keeping quality of cheese was assessed at 0, 7, 14 and 21 days. On statistical analysis, pimaricin at 10 ppm concentration was found to be highly significant (P <0.01) over 5 ppm of pimaricin, 500 and 1000 ppm of potassium sorbate with regard to anti-mycotic effect.

The study of the influence of aqueous and hydro alcoholic extracts of Tinospora cordifolia on human mammary tumor cell line MCF-7 is a common way of discovering potential therapeutics for treating people suffering from hormone-dependent problems and diseases. In the present study, the cells were treated with the extracts at three different doses viz., 200 μg/ml, 400 μg/ ml and 600 μg/ml. Both the extracts produced degenerative changes in the cell in dose-dependent manner with maximum effect being noticed at the dose level of 600 μg/ml. Thus, these findings suggest that the extracts from Tinospora cordifolia have potential for acting as an antiproliferative agent in mammary tumour.

The present study was carried out to evaluate the effect of curcumin on lipid peroxidation and antioxidant levels in DMBA (7, 12 Diemthyl Benanthracene) induced mammary carcinogenesis in rats. Twenty four Sprague-Dawley rats were equally distributed to control, DMBA, Tamoxifen (Standard drug) and curcumin groups. DMBA group showed significant (P<0.05) increase in lipid peroxidation and antioxidants superoxide dismutase (SOD) and catalase (CAT) levels besides reduced glutathione (GSH). Whereas, curcumin and Tamoxifen treated groups did not show any significant difference in lipid peroxidation and antioxidant status when compared to the control. Selective growth advantage of tumour cells was evident in the DMBA group and curcumin was able to prevent lipid peroxidation.

Campylobacter is the commonest reported bacterial cause of infectious intestinal disease. To study the epidemiology of Campylobacter infection among children, 100 stool samples along with patients anamnesis were collected from the clinical diarrheic reported to Enterology unit of Institute for child Health and centre for Children, Egmore, Chennai, Tamil Nadu between May 2013 to June 2013. Samples were subjected to traditional culture and modern PCR techniques, both of which revealed same results of 13% prevalence of Campylobacter sps (8% C.jejuni & 5% C.coli). Analyzing the patients anamnesis to study the epidemiological determinants, sex has a significance (P<0.05). Age and residential area have no significance and summer season and cross contamination could be probable determinants for the infection.