In the conditions of immunization of swine by experimental produced at Vitebsk Biofactory in the Republic of Belarus vaccines in blood of experimental swine there stated the morphological changes which pointed to formation of immune response.

After immunization of 30-35 day old piglets against a salmonellosis, pasteurellosis and streptococcosis (SPS) with special produced in the Republic of Belarus SPS vaccine in combination with immunostimulant sodium thyosulfate and vitamin C there was observed an activation myeloblastic hemopoiesis and lowering of erythropoeisis.

Analysis of morphological characteristic and parameters of a thyroid gland of a thyroid gland of growing cattle stock made it possible to specificate the age-specific and species-specific parameters of adaptation of cattle in concrete conditions of environment was realized in the conditions of cattle breeding complexes of the Republic of Belarus. As a result of studies there were obtained new data on form-building processes, macromorphology, topography and referential parameters of thyroid gland of cattle breeds.

Analysis of national studies and literary sources on problems of haemophilus pleuropneumoniae of swine was realized in the conditions of the republic of Belarus. Research was realized in the conditions of Agricultural Production Co-operative Uritskoe (Gomel region, Belarus). It was established that medical actions gave positive result only at early stages of disease.

Results of studying the local of irritating properties of preparative forms of marsh cinquefoil (Comarum palustre) which were intended for treatment of parasitic of diseases of animals, namely, strongylatosis of gastro-intestinal tract of sheep and calves realized in the conditions of the Republic of Belarus were presented. Preparative forms of Comarum palustre (liquor, tincture, liquid extract and powder) had poorly expressed irritating properties after application into skin of animals and weak irritating action, excluding native forms of tincture and liquid extract on mucous coat eye, that confirms their low toxicity action as a whole on organism of animals.

Morphological and structural changes in bone marrow of piglets which were immunized with produced in the Republic of Belarus SPS vaccine (against salmonellosis (Salmonella), pasteurellosis (Pasteurella) and streptococcus) in combination with immunostimulants and without them were analyzed in the conditions of the Republic of Belarus. Piglets of the first group were vaccinated against salmonellosis, pasteurellosis and streptoccocusis by SPS vaccine. Piglets of the second group were vaccinated by SPS vaccine with vitamin C. Piglets of the third group were vaccinated by SPS vaccine with immunotstimulant sodium thiosulphate. The fourth (control) group of animals was administrated with normal saline. Animals were immunized twice, intramuscularly with 7 day interval in dose of 4 ml (primary), and 5 ml (secondary). Vitamin С was administrated in dose of 0,05g per head. Sodium thiosulfate was administrated in combination with the vaccine in 30% concentration. Alongside with myelogram there were derived formulas of different cell groups of bone marrow: leucoerythroblastic index; intramedullary index of neutrophil maturity; intramedullary index of eosinophile maturity. Detailed myelogram of piglets on the 14-th day after the second immunization was presented. Research results showed that in all groups of vaccinated animals there was noted the activation of myeloblastic hematogenesis and decreasing of erythropoeisis. Piglet immunization was accompanied by strengthening of myeloblastic hematogenesis, increased number of lymphocytes and plasma cells in bone marrow

Development of axial skeleton bones of meat type broiler chickens of Kobb-500 and Ross-308 crosses at the postnatal ontogenesis period was investigated in the conditions of the Republic of Belarus. In course of studies there were used broilers of 5 age groups (1 day old, 20 days old, 30 days old and 40 days old) which were selected in accordance with analogous principle with 10 heads per each group. Research results showed that live weight gain as well as axial skeleton weight gain of both crosses chickens increased wavily. The highest growth intensity of body weight and axial skeleton weight was stated at broiler chickens of Kobb-500 cross at the last age period. The opposite way, there was noted the increasing of axial skeleton growth for broiler chickens of Ross-308 cross at the age of 20 days. At the further age periods till the end of fattening-off there was stated the slowing of axial skeleton and body weight. In the period of 1 to 10 days there was stated an intensive growth of cervical spine of spinal column of broiler chickens of both crosses. High intensity of absolute weight growth of cervical spine of spinal column for Kobb-500 cross chickens was stated at the age period 30-40 days; for Ross-308 cross chickens - at the age 10-20 days

Comparison of morphological changes in placenta in the conditions of physiological pregnancy and pregnancy complicated acute asphyxia in farrow with deadborn piglets was realized in the conditions of the Republic of Belarus. There were realized complex clinical and morphological studies of placenta of pregnant sows. The experimental group was formed by pegnant sows with intranatally dead fetus because of acute asphyxia in course of farrowing caused by abnormality in placental circulation(prolapse of funis or loop of cord). The second (control) group consisted of healthy bred sows with physiological farrowing and alive newborn piglets. The groups were comparable to age, number of farrowings (no more two) and housing conditions. Detailed macrographic examinations of placenta (form, size, square, weight, volume, fetus-plecentary coefficient, amnion status and so on) and cord were realized. The research result showed that in the conditions of a complicated pregnancy in the thickness index placenta there were visualized a lot of connective tissue changed locus, infarcts as well as areas, and changes in morphometric indexes. All mentioned above factors proved to be a morphological substrate of fetoplacental insufficiency, which subsequently caused asphyxia, hypoxia, small-for-gestational-age fetus, and dead birth

For the determination of efficiency of a new produced in the Republic of Belarus preparation Ehkvikar there was modeled a test with a diaphoresis of guinea pigs by means of their staying in a thermostat at a temperature of 45-50 deg C in course of 30 minutes. Before and after the test there was taken a blood test for its analysis. Results of the experiment showed that together with sudo the animals lost 1-2 % of their body. There was stated the increasing of all blood corpuscles as well as lowering in 1,3-1,47 times of such elements as chlorine, sodium, potassium, and also T lymphocytes and bursa-derived lymphocytes. Application Ehkvikar promoted the stabilization of biochemical and morphological parameters of blood, and also the immune status of laboratory animals. Thus, Ehkvikar preparation promoted the compensation of losses of electrolytes with sudor of guinea pigs and in future can be studied by an example of horses for completion of electrolytes losses in the conditions of increased physical exercises.

Development of a new national preparation for the preventive maintenance of cow mastitis, fissures of milking tubes skin of cow udder was realized in the conditions of the Republic of Belarus. The preparation Maz' Solnechnaya ("Unguent Solnechnaya") did not contain antibiotics, hormones and other synthetic components. Natural components of a preparation provide long anti-inflammatory action, stimulate local blood circulation, regeneration of epidermis and accelerate processes of healing of microtraumas. Besides it possesses high efficiency at preventive maintenance of mastitises at cows.