Water scarcity, its necessity in food production, and environmental protection in the world have forced human beings to seek new water sources. Nowadays, application of unconventional water resources (wastewater) has been proposed in countries facing the crisis of water resources shortage; however, a few studies have dealt with this issue. The present study has evaluated the changes in the elements of the soil, irrigated with wastewater. For so doing, an experiment has been conducted on a randomized complete block design with three replications. Soil samples have been collected from the studied regions at two depths of 0-30 cm and 30-60 cm and the studied parameters have included sodium, total calcium, magnesium, some acidity, and electrical conductivity of the soil. Three regions of study (namely no irrigation, irrigation with treated wastewater, and irrigation with river waters) have been taken into consideration. Results have shown increased calcium, magnesium, and pH of the effluent from Zabol Wastewater Treatment Plant compared to the control; however, electrical conductivity and chloride have decreased in wastewater-irrigated soil. The electrical conductivity in the surface layer of wastewater samples, treated with an amount of 2.25 (ds/m), has had the most significant difference to the control and other treatments. It can be concluded that wastewater increases some soil properties, contributing to its restoration.