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Characteristics of air pollutants inside and outside a primary school classroom in Beijing and respiratory health impact on children
2019
Zhang, Lulu | Morisaki, Hiroshi | Wei, Yongjie | Li, Zhigang | Yang, Lu | Zhou, Quanyu | Zhang, Xuan | Xing, Wanli | Hu, Min | Shima, Masayuki | Toriba, Akira | Hayakawa, Kazuichi | Tang, Ning
This study investigated the spatial and temporal distributions of particulate and gaseous air pollutants in a primary school in Beijing and assessed their health impact on the children. The results show that air quality inside the classroom was greatly affected by the input of outdoor pollutants; high levels of pollution were observed during both the heating and nonheating periods and indicate that indoor and outdoor air pollution posed a threat to the children's health. Traffic sources near the primary school were the main contributors to indoor and outdoor pollutants during both periods. Moreover, air quality in this primary school was affected by coal combustion and atmospheric reactions during the heating and nonheating periods, respectively. Based on the estimation by exposure-response functions and the weighting of indoor and outdoor pollutants during different periods, the levels of PM2.5, PM 10 and O3 at school had adverse respiratory health effects on children. Longer exposures during the nonheating period contributed to higher health risks. These results emphasized that emission sources nearby had a direct impact on air quality in school and children's respiratory health. Therefore, measures should be taken for double control on air pollution inside and outside the classroom to protect children from it.
Show more [+] Less [-]Coal mine fire effects on carcinogenicity and non-carcinogenicity human health risks
2019
Roy, Debananda | Singh, Gurdeep | Seo, Yong-Chil
Atmospheric particulate matter (PM) pollution levels and human health risks resulting from exposure to non-anthropogenic pollution sources, such as coal mine-fires, are serious global issues. The toxicity of PM₁₀-bound metals and polycyclic aromatic hydrocarbons (PAHs) was assessed according to their non-cancer and cancer risks (CRs) at the mine-fire and in an adjacent city area. Health risks were estimated for inhalation, ingestion, and dermal absorption pathways. The non-cancer risks, presented in terms of the hazard index (HI) and hazard quotient (HQ), were found to be significant (>1) at all locations, except in the mining (for HQ-dermal) and city background area (for HQ-ingestion and HQ-dermal) in children and adults, respectively. The total CR was estimated to be highest at the city nearby the mine-fire area (3.31E-02 and 1.93E-02) followed by the mine-fire area (2.66E-02 and 1.71E-02) for children and adults, respectively. The total CR and CR via individual exposure routes were estimated to be in the high risk (10⁻³ ≤ CR < 10⁻¹) category at the mine-fire site and adjacent city area. For all exposures, CR levels were calculated to be higher than the acceptable range (from 1.00E-06 to 1.00E-04), except for the CR-inhalation level at the A5 location. Among all elements, Cd and BaPₑqᵤ were more significant for the CR at the coal mine-fire and the adjacent city area. Hence, this study concluded that non-anthropogenic sources, such as coal mine-fires, could be part for the significant health risk (carcinogenic and non-carcinogenic) levels in the study area.
Show more [+] Less [-]Parabens in breast milk and possible sources of exposure among lactating women in Korea
2019
Park, Na-Youn | Cho, Yoon Hee | Choi, Kyungho | Lee, Eun-hee | Kim, Yang Jee | Kim, Jung Hoan | Kho, Younglim
Parabens, broad-spectrum antimicrobial preservatives widely used in various consumer products and food, are suspected to be linked with several adverse health effects in humans, especially newborn babies, infants, and young children. While human exposure to parabens has been frequently reported by measuring the concentration of parabens in urine, similar measurements in breast milk have rarely been made. To determine paraben concentrations in breast milk and possible sources of exposure, four major parabens, including methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butylparaben (BP) were measured in breast milk samples collected from 260 lactating women in South Korea. Demographic, socioeconomic, and behavioral factors associated with the presence of parabens in breast milk were determined. EP concentrations were detected at the highest levels in breast milk samples, followed by MP, PP, and BP. Pre-pregnancy BMI, parity, use of basic skin care products, use of cosmetics, canned beverage, and type of milk consumption were associated with higher frequencies of paraben detection. In addition, type of milk, parity, and drinking status were significantly associated with the concentration of EP. Multiple regression analyses showed that colostrum and transitional milk samples had higher levels of EP than mature milk samples. The estimated daily intake of parabens in infants via breastfeeding appears to be negligible when compared to the acceptable daily intake values set forth by the European Food Safety Authority (EFSA); however, considering the vulnerability of breastfed infants and ubiquitous sources of exposure from daily use of household and personal toiletries, efforts to identify sources and mitigate exposure are warranted.
Show more [+] Less [-]Perfluoroalkyl acids in paired serum, urine, and hair samples: Correlations with demographic factors and dietary habits
2019
Kim, Da-Hye | Lee, Jong Hyeon | Oh, Jeong-Eun
We analyzed paired serum, urine, and hair samples from 94 Korean children and adults to investigate levels of 11 perfluoroalkyl acids (PFAAs). The effects of demographic factors and dietary habits on PFAA exposure were also assessed based on the paired samples. The total PFAA concentrations were 2.4–31 ng/mL in serum, not detected–9.5 ng/mL in urine, and 0.48–15 ng/g in hair. Levels of perfluoropentanoic acid (PFPeA) and perfluorohexanoic acid (PFHxA), which have short carbon chains, were 1.5–5 fold higher in urine and hair than in serum. The PFAA concentrations in serum exhibited a decreasing trend with age from young childhood to adolescence, followed by an increasing trend after adolescence. For most PFAA species, concentrations in serum were higher in adult males than in adult females (p < 0.01). No sex difference was evident in the urine and hair samples. In addition, there was no age difference in the urine samples, but in the hair samples, we observed higher concentrations of PFAAs in children than in the other age groups (p < 0.01). The consumption rates of fish and water showed significant correlations with serum (positive correlation) and hair (negative) concentrations, respectively. No relationships between serum and hair/urine levels for most PFAAs were observed, except between serum and hair levels for perfluorooctanoic acid (PFOA).
Show more [+] Less [-]Abundances and concentrations of brominated azo dyes detected in indoor dust
2019
Dhungana, Birendra | Peng, Hui | Kutarna, Steven | Umbuzeiro, Gisela | Shrestha, Sujan | Liu, Jing | Jones, Paul D. | Subedi, Bikram | Giesy, John P. | Cobb, George P.
Dust samples were collected from four indoor environments, including childcare facilities, houses, hair salons, and a research facility from the USA and were analyzed for brominated compounds using full scan liquid chromatography high-resolution mass spectrometry. A total of 240 brominated compounds were detected in these dust samples, and elemental formulas were predicted for 120 more abundant ions. In addition to commonly detected brominated flame retardants (BFRs), nitrogen-containing brominated azo dyes (BADs) were among the most frequently detected and abundant. Specifically, greater abundances of BADs were detected in indoor dusts from daycares and salons compared to houses and the research facility. Using authentic standards, a quantitative method was established for two BADs (DB373: Disperse Blue 373 and DV93: Disperse Violet 93) and 2-bromo-4,6-dinitroaniline, a commonly used precursor in azo dye production, in indoor dust. Generally, greater concentrations of DB373 (≤3850 ng/g) and DV93 (≤1190 ng/g) were observed in indoor dust from daycares highlighting children as a susceptible population to potential health risk from exposure to BADs. These data are important because, to date, targeted analysis of brominated compounds in indoor environments has focused mainly on BFRs and appears to underestimate the total amount of brominated compounds.
Show more [+] Less [-]A comprehensive risk assessment of human inhalation exposure to atmospheric halogenated flame retardants and organophosphate esters in an urban zone
2019
Hu, Yuan-Jie | Bao, Lian-Jun | Huang, Chun-Li | Li, Shao-Meng | Zeng, E. Y. (Eddy Y.)
Inhalation exposure to flame retardants used as additives to minimize fire risk and plasticizers is ubiquitous in human daily activities, but has not been adequately assessed. To address this research gap, the present study conducted an assessment of human health risk for four age groups through inhalation exposure to size fractionated particle-bound and gaseous halogenated flame retardants (polybrominated diphenyl ethers (PBDEs) and alternative halogenated flame retardants (AHFRs)) and organophosphate esters (OPEs) at indoor and outdoor environments (school, office, and residence) in three districts of a megacity (Guangzhou, China). Results demonstrated that OPEs were the dominant components among all targets. Indoor daily intakes of PBDEs and OPEs were 13–16 times greater than outdoor levels for all age groups. Gaseous OPEs contributed significantly greater than particle-bound compounds to daily intakes of all target compounds. Based on the different life scenarios, hazard quotient (HQ) and incremental life cancer risk (ILCR) from adults exposure to PBDEs and OPEs in indoor and outdoor settings were the greatest, followed by adolescents, children, and seniors. The estimated HQ and ILCR for all age groups both indoors and outdoors were lower than the safe level (HQ = 1 and ILCR = 10−6), indicating that the potential health risk for local residents in Guangzhou via inhalation exposure to atmospheric halogenated flame retardants and OPEs was low.
Show more [+] Less [-]Characteristic and human exposure risk assessment of per- and polyfluoroalkyl substances: A study based on indoor dust and drinking water in China
2019
Ao, Junjie | Yuan, Tao | Xia, Hui | Ma, Yuning | Shen, Zhemin | Shi, Rong | Tian, Ying | Zhang, Jun | Ding, Wenjin | Gao, Li | Zhao, Xiaodong | Yu, Xiaodan
Per- and polyfluoroalkyl Substances (PFAS) are ubiquitous in the environmental matrix, and their eco-toxicity on wide life and health risks on humans arising concerns. Due to the information gap, current risk assessments of PFAS ignore the indoor exposure pathway such as indoor dust and the different sources of drinking water. We collected and analyzed 168 indoor dust and 27 drinking water samples (including tap water, filtered water and bottled water). The mean concentrations of six typical PFAS measured in indoor dust and drinking water are in the range of 15.13–491.07 ng g⁻¹ and 0.31–4.14 ng L⁻¹, respectively. For drinking water, PFOA and PFOS were the dominant compounds, while PFHxS was the most abundant in indoor dust. Short-chain PFAS concentrations were higher than long-chain PFAS in both drinking water and indoor dust. Higher concentration of PFAS was observed in tap water and filtered water than bottled water. The total daily intake (TDI) of six PFAS are 20.67–52.97 ng kg⁻¹ d⁻¹ for infants, children, teenagers, and adults. As to children, teenagers, and adults, perfluorooctanoate (PFOA) is the major compound, accounting for 72.9–74.7% of the total daily intake. And PFOA (38.7%) and perfluorooctane sulfonate (PFOS, 42.2%) are the dominant PFAS for infants. The quantitative proportions of exposure sources are firstly revealed in this study, which in the order of foodstuff > indoor dust > drinking water > indoor air. Although the contribution to the PFAS intake of drinking water and indoor dust was not predominant (<9%), the health risks caused by long-term exposure need our attention. The hazard quotient (HQ) values of total PFAS were in the range of 0.154–0.498, which suggesting the relatively lower exposure risk in Chinese population. This study provides important reference to understand PFAS exposure status other than foodstuff.
Show more [+] Less [-]Assessment of airborne enteric viruses emitted from wastewater treatment plant: Atmospheric dispersion model, quantitative microbial risk assessment, disease burden
2019
Pasalari, Hasan | Ataei-Pirkooh, Angila | Aminikhah, Mahdi | Jafari, Ahmad Jonidi | Farzadkia, Mahdi
From a health prospective, it is critical to provide a comprehensive model which integrates all the parameters involved in virus transmission and its consequences on human body. In order to estimate the health risks, for workers and residents, associated with an exposure airborne viruses emitted from a wastewater treatment (WWTP), the concentration levels of viruses in emitted bioaerosols over a twelve-month period were measured by real-time polymerase chain reaction (RT-PCR). A combined Gaussian plum dispersion model and quantitative microbial risk assessment (QMRA) with Monte-Carlo simulation served as suitable explanatory tools to estimate the risk of acquiring gastrointestinal illness (GI) due to exposure to air containing Rotavirus (RoV) and Norovirus (NoV) bioaerosols. Additionally, DALY metric was applied to quantify the disability and mortality for workers and residents. RoV and NoV were detected above aeration tank with annual mean concentration 27 and 3099 (Viruses/m³.h), respectively. The medium calculated DALY indicator based on viral loads in contaminant source (RoV:5.76 × 10⁻² and NoV:1.23 × 10⁻¹) and estimated in different distances away (300–1000 m) (RoV:2.87 × 10⁻²- 2.75 × 10⁻² and NoV:1.14 × 10⁻¹-1.13 × 10⁻¹) were markedly higher than the threshold values recommended by US EPA (10⁻⁴ DALY pppy) and WHO (10⁻⁶ DALY pppy). The sensitivity analysis highlighted dose exposure and disease burden per case (DBPC) as two most influential factors for both workers and residents following exposure to two pathogens of concern. Due to high resistance and high concentration in the environment, the presence of RoV and NoV can intensify the consequences of diarrhea especially for children under five years of age; A comprehensible and transparent presentation of DALYs and QMRA can help decision makers and responsibilities to justify the priorities of exposure to wastewater in comparison with other risks of daily life.
Show more [+] Less [-]Geochemical exposure of heavy metals in environmental samples from the vicinity of old gas mining area in northern part of Sindh Pakistan. Adverse impact on children
2019
Shaikh, Rafia | Kazi, Tasneem Gul | Afridi, Hassan Imran | Akhtar, Asma | Baig, Jameel Ahmed | Arain, Mohammad Balal
In early nineteen century, a gas field was operational in southern part of Sindh, Pakistan for power production. The plant was completely un-operational for last three decades, whereas all wastage and raw materials are still dumped there, which might be the source to contaminate the ground water. The most of the workers population still living in different villages nearby the gas field. In present study, evaluated the undesirable effects of the toxic metals (lead and cadmium) via consuming groundwater for drinking and other domestic purpose especially in children of ≤5.0 years. For comparative purpose groundwater of nonindustrial area (nonexposed) was also analysed and their impact on age matched children was carried out. Biological samples (scalp hair and blood) were collected from children of exposed and nonexposed areas. The Cd and Pb in scalp hair and blood samples were carried out by graphite furnace atomic absorption spectrometry. Whereas, Cd and Pb in groundwater obtained from both areas were determined prior to applied preconcentration method as reported in our previous works. The Cd and Pb contents in the groundwater of villages of exposed area were found in the range of 5.18–10.9 and 19.9–69.5 μg/L, respectively. Whereas, the groundwater of nonexposed area contains Cd and Pb in the range of 1.79–3.78 and 5.07–24.3 μg/L, respectively. It was observed that the concentrations of Cd and Pb in scalp hair and blood samples of children belongs to exposed area have ≥2.0 fold higher than the resulted data attained for age matched control children, indicating as the exposure biomarkers of toxic metals. The children belong to exposed area have poor health, anemic and low body mass index (<13 kg/m2). A significant positive correlations among Cd and Pb concentrations in biological samples of exposed subjects and groundwater was observed (p < 0.01).
Show more [+] Less [-]Contributions of artifactual materials to the toxicity of anthropogenic soils and street dusts in a highly urbanized terrain
2019
Howard, Jeffrey | Weyhrauch, Jonathan | Loriaux, Glenn | Schultz, Brandy | Baskaran, Mark
A study was undertaken to test the hypothesis that the presence of fly ash and other artifactual materials (AMs) significantly increases the toxicity of urban soil and street dust. AMs were distinguished as artifacts (artificial particles > 2 mm in size), and particulate artifacts (≤2 mm in size); street dust was the <63 μm fraction of street sediments. Reference artifacts, street dusts, and topsoils representing different land use types in Detroit, Michigan were analyzed for miscellaneous radionuclides, trace elements, magnetic susceptibility (MS), and acetic acid-extractable (leachable) Pb. Background levels were established using native glacial sediments. Street sediments were found to have a roadside provenance, hence street dusts inherited their contamination primarily from local soils. All soils and dusts had radionuclide concentrations similar to background levels, and radiological hazard indices within the safe range. Artifacts, fly ash-impacted soils and street dusts contained elevated concentrations of toxic trace elements, which varied with land use type, but none produced a significant amount of leachable Pb. It is inferred that toxic elements in AMs are not bioavailable because they are occluded within highly insoluble materials. Hence, these results do not support our hypothesis. Rather, AMs contribute to artificially-elevated total concentrations leading to an overestimation of toxicity. MS increased with increasing total concentration, hence proximal sensing can be used to map contamination level, but the weak correlation between total and leachable Pb suggests that such maps do not necessarily indicate the associated biohazard. Home site soils with total Pb concentrations >500 mg kg−1 were sporadically toxic. Thus, these results argue against street dust as the local cause of seasonally elevated blood-Pb levels in children. Lead-bearing home site soil tracked directly indoors to form house dust is an alternative exposure pathway.
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