Jegricka water body is part of the Main Drainage Channel System. The whole length of Jegricka (65 km, catchment surface 60.380 ha) is located in south part of Backa, Vojvodina Province. This highly modified water flow has become protected area since 2005 due to its specific natural features - diversity and uniqueness of biotic features, especially for birds and plants. In July 2008 survey of freshwater macroinvertebrates was conducted in order to assess water quality and conservation potential according to biotic characteristics according to conservation criteria within SERCON (System for Evaluating Rivers for Conservation) method. The aim of this paper was to evaluate the importance of macroinvertebrates as indicators of conservation potential of Jegricka water using SERCON. Results of analyses of species composition of freshwater invertebrates fauna showed presence of 12 higher taxonomic groups. Within these groups, 23 families were present at eight RHS river sections along investigated part of Jegricka water body. Togheter with SERCON based conservation criteria for macroinvertebrate, two types of biotic indices Biological Monitoring Working Party (BMWP) and Average Score Per Taxon (ASPT) were calculated in order to assess water quality. Results of the survey showed that Jegricka water body belongs probably to moderately polluted water type according to biotic indices. Results of conservation criteria Naturaless showed that observed and expected faunas are similar. Low values of SERCON family richness criteria based on whole length of water body indicate that Jegricka has low conservation potential, and that adequate rehabilitation measures should be considered in the future.