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Assessing exposure risks for aquatic organisms posed by Tamiflu use under seasonal influenza and pandemic conditions
2014
Chen, Wei-Yu | Lin, Jiarong | Liao, Chung-Min
Environmental pollution by anti-influenza drugs is increasingly recognized as a threat to aquatic environments. However, little is known about empirical data on risk effects posed by environmentally relevant concentrations of anti-influenza drug based on recently published ecotoxicological researches in Taiwan. Here we linked ecotoxicology models with an epidemiological scheme to assess exposure risks of aquatic organisms and environmental hazards posed by antiviral oseltamivir (Tamiflu) use in Taiwan. Built on published bioassays, we used probabilistic risk assessment model to estimate potential threats of environmentally relevant hazards on algae, daphnid, and zerbrafish. We found that Tamiflu use was unlikely to pose a significant chronic environmental risk to daphnia and zebrafish during seasonal influenza. However, the chronic environmental risk posed by Tamiflu use during pandemic was alarming. We conclude that no significant risk to algal growth was found during seasonal influenza and high pandemic Tamiflu use.
Show more [+] Less [-]Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins
2014
Fernández, Ignacio | Santos, Adriana | Cancela, M Leonor | Laizé, Vincent | Gavaia, Paulo J.
Warfarin-induced vitamin K (VK) recycling impairment is used worldwide as a rodenticide and human thromboembolic prophylactic. Since VK metabolism/signaling pathways have been conserved throughout vertebrate evolution, its release to the environment might impact on aquatic organisms. Present study assessed the toxic effect of warfarin (0, 5, 25 and 125 mg L−1) on zebrafish development and characterized underlying mechanisms of action through qPCR analysis of VK-related genes. Expression of pregnane X receptor (pxr), the nuclear receptor binding vitamin K, was ubiquitous in zebrafish and suggests that warfarin exposure may interfere with several biological processes. Indeed, warfarin exposure of zebrafish larvae caused hemorrhages in brain, skeletal deformities and triggered ectopic calcifications, which may be the consequence of an altered γ-carboxylation of VK-dependent proteins and/or pxr signaling. This study provides new insights into warfarin effects as a bone homeostasis disruptor and soft tissue calcification inductor, and its potential risk for aquatic environments.
Show more [+] Less [-]Toxic assessment of urban atmospheric particle-bound PAHs: Relevance of composition and particle size in Barcelona (Spain)
2014
Mesquita, Sofia Raquel | van Drooge, Barend L. | Reche, Cristina | Guimarães, Laura | Grimalt, Joan O. | Barata, Carlos | Piña, Benjamin
Zebrafish embryotoxicity and dioxin-like activity levels were tested for particulate air samples from an urban background site in Barcelona (Spain). Samples were collected during 14 months, and maximal values for both biological activities corresponded to samples collected during late autumn months, correlating with elevated PAH levels. Vehicle and combustion emissions appeared as the potentially most toxic sources, whereas total PM mass and mineral content appeared to be poor predictors of the biological activity of the samples. Samples simultaneously collected at different particle size cut-offs (10, 2.5, and 1 μm) did not differ significantly in dioxin-like PAH levels and biological activity, indicating that the sub-micron particle fraction (PM1) concentrated essentially all observed toxicity. Our results support the need for a tighter control on sub-micron particle emissions and show that total PM mass and, particularly, PM10, may not fully characterize the toxic potential of air samples.
Show more [+] Less [-]Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment
2014
Vignet, Caroline | Devier, Marie Helene | Le Menach, Karyn | Lyphout, Laura | Potier, Jérémy | Cachot, Jérôme | Budzinski, Hélène | Bégout, Marie-Laure | Cousin, Xavier | Laboratoire d'Écotoxicologie (LEX) ; Biogéochimie et Ecotoxicologie (BE) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Environnements et Paléoenvironnements OCéaniques (EPOC) ; Observatoire aquitain des sciences de l'univers (OASU) ; Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) | Laboratoire Ressources Halieutiques (LRH) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) | ANR ConPhyPop (2009-002) ; CPER A2E ; European Regional Development Fund ; Region Poitou-Charentes ; Ifremer | ANR-09-CESA-0002,CONPHYPOP,Contamination et physiologie des poissons aux polluants(2009)
A natural sediment spiked with three individual polycyclic aromatic hydrocarbons (PAHs; pyrene, phenanthrene and benzo[a]pyrene) was used to expose zebrafish embryos and larvae during 4 days. The total PAH concentration was 4.4 μg g−1 which is in the range found in sediment from contaminated areas. Quantification of metabolites in the larvae after exposure confirmed the actual contamination of the larvae and indicated an active metabolism specially for pyrene and benzo[a]pyrene. After a transfer in a clean medium, the larvae were reared to adulthood and valuated for survival, growth, reproduction, and behavior. Measured endpoints revealed a late disruption of growth (appearing at 5 months) and a trend toward a lower reproductive ability. Adults of embryos exposed to sediment spiked with PAHs displayed lethargic and/or anxiety-like behaviors. This latter behavior was also identified in offspring at larval stage. All together, these effects could have detrimental consequences on fish performances and contribution to recruitment.
Show more [+] Less [-]Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish - part I: survival and growth
2014
Vignet, Caroline | Le Menach, Karyn | Mazurais, David | Lucas, Julie | Perrichon, Prescilla | Le Bihanic, Florane | Devier, Marie Helene | Lyphout, Laura | Frère, Laura | Bégout, Marie-Laure | Zambonino-Infante, Jose-Luis | Budzinski, Hélène | Cousin, Xavier | Laboratoire d'Écotoxicologie (LEX) ; Biogéochimie et Ecotoxicologie (BE) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Environnements et Paléoenvironnements OCéaniques (EPOC) ; Observatoire aquitain des sciences de l'univers (OASU) ; Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) | Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR) ; Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM) ; Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) | LIttoral ENvironnement et Sociétés (LIENSs) ; La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS) | Laboratoire Ressources Halieutiques (LRH) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) | ANR ConPhyPop (2009-002) ; CPER A2E ; European Regional Development Fund ; Région Poitou-Charentes ; Ifremer ; Conseil Général de Charente-Maritime ; Ministère de l'Enseignement Supérieur de la Recherche | ANR-09-CESA-0002,CONPHYPOP,Contamination et physiologie des poissons aux polluants(2009)
The release of polycyclic aromatic hydrocarbons (PAHs) into the environment has increased very substantially over the last decades leading to high concentrations in sediments of contaminated areas. To evaluate the consequences of long-term chronic exposure to PAHs, zebrafish were exposed, from their first meal at 5 days post fertilisation until they became reproducing adults, to diets spiked with three PAH fractions at three environmentally relevant concentrations with the medium concentration being in the range of 4.6–6.7 μg g−1 for total quantified PAHs including the 16 US-EPA indicator PAHs and alkylated derivatives. The fractions used were representative of PAHs of pyrolytic (PY) origin or of two different oils of differing compositions, a heavy fuel (HO) and a light crude oil (LO). Fish growth was inhibited by all PAH fractions and the effects were sex specific: as determined with 9-month-old adults, exposure to the highest PY inhibited growth of females; exposure to the highest HO and LO inhibited growth of males; also, the highest HO dramatically reduced survival. Morphological analysis indicated a disruption of jaw growth in larvae and malformations in adults. Intestinal and pancreatic enzyme activities were abnormal in 2-month-old exposed fish. These effects may contribute to poor growth. Finally, our results indicate that PAH mixtures of different compositions, representative of situations encountered in the wild, can promote lethal and sublethal effects which are likely to be detrimental for fish recruitment.
Show more [+] Less [-]Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish—part II: behavior
2014
Vignet, Caroline | Le Menach, Karyn | Lyphout, Laura | Guionnet, Tiphaine | Frère, Laura | Leguay, Didier | Budzinski, Hélène | Cousin, Xavier | Bégout, Marie-Laure | Laboratoire d'Écotoxicologie (LEX) ; Biogéochimie et Ecotoxicologie (BE) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Environnements et Paléoenvironnements OCéaniques (EPOC) ; Observatoire aquitain des sciences de l'univers (OASU) ; Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) | Laboratoire Ressources Halieutiques (LRH) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) | ANR project ConPhyPoP (CES 09_002) and CPER A2E ; European Union and European Fund for Regional Development ; Région Poitou-Charentes ; Institut Français de Recherche pour l’Exploitation de la Mer ; LABEX COTE cluster of excellence “Continental to coastal ecosystems” | ANR-09-CESA-0002,CONPHYPOP,Contamination et physiologie des poissons aux polluants(2009) | ANR-10-IDEX-0003,IDEX BORDEAUX,Initiative d'excellence de l'Université de Bordeaux(2010)
International audience | In the last 10 years, behavior assessment has been developed as an indicator of neurotoxicity and an integrated indicator of physiological disruption. Polycyclic aromatic hydrocarbon (PAH) release into the environment has increased in recent decades resulting in high concentrations of these compounds in the sediment of contaminated areas. We evaluated the behavioral consequences of long-term chronic exposure to PAHs, by exposing zebrafish to diets spiked with three PAH fractions at environmentally relevant concentrations. Fish were exposed to these chemicals from their first meal (5 days postfertilization) until they became reproducing adults (at 6 months old). The fractions used were representative of PAHs of pyrolytic (PY) origin and of two oils differing in composition (a heavy fuel oil (HO) and a light crude oil (LO)). Several tests were carried out to evaluate circadian spontaneous swimming activity, responses to a challenge (photomotor response), exploratory tendencies, and anxiety levels. We found that dietary PAH exposure was associated with greater mobility, lower levels of exploratory activity, and higher levels of anxiety, particularly in fish exposed to the HO fraction and, to a lesser extent, the LO fraction. Finally, our results indicate that PAH mixtures of different compositions, representative of situations encountered in the wild, can induce behavioral disruptions resulting in poorer fish performance.
Show more [+] Less [-]Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish—part II: behavior
2014
Vignet, Caroline | Le Menach, Karyn | Lyphout, Laura | Guionnet, Tiphaine | Frère, Laura | Leguay, Didier | Budzinski, Hélène | Cousin, Xavier | Bégout, Marie-Laure | Unité Biogéochimie et Ecotoxicologie (BE) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Environnements et Paléoenvironnements OCéaniques (EPOC) ; Observatoire aquitain des sciences de l'univers (OASU) ; Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Centre National de la Recherche Scientifique (CNRS) | Laboratoire Ressources Halieutiques La Rochelle-L'Houmeau ( LRHLR) ; Unité Halieutique Gascogne Sud (HGS) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | Laboratoire de Physiologie et Génomique des Poissons (LPGP) ; Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) | ANR project ConPhyPoP (CES 09_002) and CPER A2E ; European Union and European Fund for Regional Development ; Région Poitou-Charentes ; Institut Français de Recherche pour l’Exploitation de la Mer ; LABEX COTE cluster of excellence “Continental to coastal ecosystems” | ANR-09-CESA-0002,CONPHYPOP,Contamination et physiologie des poissons aux polluants(2009) | ANR-10-IDEX-0003,IDEX BORDEAUX,Initiative d'excellence de l'Université de Bordeaux(2010)
International audience | In the last 10 years, behavior assessment has been developed as an indicator of neurotoxicity and an integrated indicator of physiological disruption. Polycyclic aromatic hydrocarbon (PAH) release into the environment has increased in recent decades resulting in high concentrations of these compounds in the sediment of contaminated areas. We evaluated the behavioral consequences of long-term chronic exposure to PAHs, by exposing zebrafish to diets spiked with three PAH fractions at environmentally relevant concentrations. Fish were exposed to these chemicals from their first meal (5 days postfertilization) until they became reproducing adults (at 6 months old). The fractions used were representative of PAHs of pyrolytic (PY) origin and of two oils differing in composition (a heavy fuel oil (HO) and a light crude oil (LO)). Several tests were carried out to evaluate circadian spontaneous swimming activity, responses to a challenge (photomotor response), exploratory tendencies, and anxiety levels. We found that dietary PAH exposure was associated with greater mobility, lower levels of exploratory activity, and higher levels of anxiety, particularly in fish exposed to the HO fraction and, to a lesser extent, the LO fraction. Finally, our results indicate that PAH mixtures of different compositions, representative of situations encountered in the wild, can induce behavioral disruptions resulting in poorer fish performance.
Show more [+] Less [-]Whole genome data for omics-based research on the self-fertilizing fish Kryptolebias marmoratus
2014
Rhee, Jae-Sung | Lee, Jae-seong
Genome resources have advantages for understanding diverse areas such as biological patterns and functioning of organisms. Omics platforms are useful approaches for the study of organs and organisms. These approaches can be powerful screening tools for whole genome, proteome, and metabolome profiling, and can be used to understand molecular changes in response to internal and external stimuli. This methodology has been applied successfully in freshwater model fish such as the zebrafish Danio rerio and the Japanese medaka Oryzias latipes in research areas such as basic physiology, developmental biology, genetics, and environmental biology. However, information is still scarce about model fish that inhabit brackish water or seawater. To develop the self-fertilizing killifish Kryptolebias marmoratus as a potential model species with unique characteristics and research merits, we obtained genomic information about K. marmoratus. We address ways to use these data for genome-based molecular mechanistic studies. We review the current state of genome information on K. marmoratus to initiate omics approaches. We evaluate the potential applications of integrated omics platforms for future studies in environmental science, developmental biology, and biomedical research. We conclude that information about the K. marmoratus genome will provide a better understanding of the molecular functions of genes, proteins, and metabolites that are involved in the biological functions of this species. Omics platforms, particularly combined technologies that make effective use of bioinformatics, will provide powerful tools for hypothesis-driven investigations and discovery-driven discussions on diverse aspects of this species and on fish and vertebrates in general.
Show more [+] Less [-]Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish—part II: behavior
2014
Vignet, Caroline | Le Menach, Karyn | Lyphout, Laura | Guionnet, Tiphaine | Frere, Laura | Leguay, Didier | Budzinski, Helene | Cousin, Xavier | Begout, Marie-laure
In the last 10 years, behavior assessment has been developed as an indicator of neurotoxicity and an integrated indicator of physiological disruption. Polycyclic aromatic hydrocarbon (PAH) release into the environment has increased in recent decades resulting in high concentrations of these compounds in the sediment of contaminated areas. We evaluated the behavioral consequences of long-term chronic exposure to PAHs, by exposing zebrafish to diets spiked with three PAH fractions at environmentally relevant concentrations. Fish were exposed to these chemicals from their first meal (5 days postfertilization) until they became reproducing adults (at 6 months old). The fractions used were representative of PAHs of pyrolytic (PY) origin and of two oils differing in composition (a heavy fuel oil (HO) and a light crude oil (LO)). Several tests were carried out to evaluate circadian spontaneous swimming activity, responses to a challenge (photomotor response), exploratory tendencies, and anxiety levels. We found that dietary PAH exposure was associated with greater mobility, lower levels of exploratory activity, and higher levels of anxiety, particularly in fish exposed to the HO fraction and, to a lesser extent, the LO fraction. Finally, our results indicate that PAH mixtures of different compositions, representative of situations encountered in the wild, can induce behavioral disruptions resulting in poorer fish performance.
Show more [+] Less [-]Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish - part I: Survival and growth
2014
Vignet, Caroline | Le Menach, Karyn | Mazurais, David | Lucas, Julie | Perrichon, Prescilla | Le Bihanic, Florane | Devier, Marie-hélène | Lyphout, Laura | Frere, Laura | Begout, Marie-laure | Zambonino Infante, Jose-luis | Budzinski, Helene | Cousin, Xavier
The release of polycyclic aromatic hydrocarbons (PAHs) into the environment has increased very substantially over the last decades leading to high concentrations in sediments of contaminated areas. To evaluate the consequences of long-term chronic exposure to PAHs, zebrafish were exposed, from their first meal at 5 days post fertilisation until they became reproducing adults, to diets spiked with three PAH fractions at three environmentally relevant concentrations with the medium concentration being in the range of 4.6–6.7 μg g−1 for total quantified PAHs including the 16 US-EPA indicator PAHs and alkylated derivatives. The fractions used were representative of PAHs of pyrolytic (PY) origin or of two different oils of differing compositions, a heavy fuel (HO) and a light crude oil (LO). Fish growth was inhibited by all PAH fractions and the effects were sex specific: as determined with 9-month-old adults, exposure to the highest PY inhibited growth of females; exposure to the highest HO and LO inhibited growth of males; also, the highest HO dramatically reduced survival. Morphological analysis indicated a disruption of jaw growth in larvae and malformations in adults. Intestinal and pancreatic enzyme activities were abnormal in 2-month-old exposed fish. These effects may contribute to poor growth. Finally, our results indicate that PAH mixtures of different compositions, representative of situations encountered in the wild, can promote lethal and sublethal effects which are likely to be detrimental for fish recruitment.
Show more [+] Less [-]