Pesticide application has increased globally with increasing demand for food, and modernized Agriculture as a result of an explosion in the world’s population growth, especially in developing nations in Africa, Asia, and South America. However, pesticides have helped to improve productivity, protect the nutritive integrity of food crops, and ensure year-round food supplies worldwide. The production and consumption of pesticides persisted from one decade to another until the ecosystem started to suffer from its adverse effects on the environment and human health. Previous investigations revealed that pesticides found entry into the human food chain. In response to these problems, researchers all over the world have conducted several kinds of research on pesticide applications, and their residual contamination in food. This review crosses from the past to present researches on the usage of pesticides, their accumulation in food, and possible methods of their reduction as highlighted by researchers over many years. There is a need for continuous monitoring of pesticide residue profile in soil, crop produce, and animal products in developing countries so that it will not exceed maximum residue limits (MRLs).