Formaldehyde has been documented to be naturally present in many common foods. There has been a big public concern over the use of formaldehyde in the preservation of food. Also, it is commonly used as a chemical substance, usually in the life and can interact with many bio-substance in the human body. The present study target to investigate the protective effects of  Cymbopogon schoenanthus (CS) extract against the reproductive and carcinogenic effects of formaldehyde on male rats. The Albino male rats were divided into equal six groups, first group: rendered as a control group; second group: received formalin (100 mg/kg bw) and third group and forth group: were received SC extract at (50 and 100 mg) respectively; fifth group and sixth group were received formalin (100mg /kg bw) + SC extract (50mg) and formalin (100mg /kg bw)+ SC extract (100 mg) respectively. At the end of the experiment the animals were scarified and blood samples were collected for measurement all tested parameters. The results showed that the oral exposure to formaldehyde at a dose of 100 mg/kg bw resulted in significant negative effects in all tested parameters, while the CS extract at tow doses (50 and 100 mg) alone or in combination with formalin restored the negative effects to normal levels compared with the untreated group. The histopathological examination was studied on testis tissues and the histopathological pictures showed the CS extract at tow mention doses had ameliorate the adverse effects that induced by formaldehyde hazards.

Asthma is a respiratory disease that can be exacerbated by certain environmental factors. Both formaldehyde (FA) and PM₂.₅, the most common indoor and outdoor air pollutants in mainland China, are closely associated with the onset and development of asthma. To date, however, there is very little report available on whether there is an exacerbating effect of combined exposure to FA and PM₂.₅ at ambient concentrations. In this study, asthmatic mice were exposed to 1 mg/m³ FA, 1 mg/kg PM₂.₅, or a combination of 0.5 mg/m³ FA and 0.5 mg/kg PM₂.₅, respectively. Results demonstrated that both levels of oxidative stress and inflammation were significantly increased, accompanied by an obvious decline in lung function. Further, the initial activation of p38 MAPK and NF-κB that intensified the immune imbalance of asthmatic mice were found to be visibly mitigated following the administration of SB203580, a p38 MAPK inhibitor. Noteworthily, it was found that combined exposure to the two at ambient concentrations could significantly worsen asthma than exposure to each of the two alone at twice the ambient concentration. This suggests that combined exposure to formaldehyde and PM₂.₅ at ambient concentrations may have a synergistic effect, thus causing more severe damage in asthmatic mice. In general, this work has revealed that the combined exposure to FA and PM₂.₅ at ambient concentrations can synergistically aggravate asthma via the p38 MAPK pathway in mice.

India struggles with frequent exceedances of the ambient air quality standard for particulate matter and benzene. In the past two decades, India has made considerable progress in tackling indoor air pollution, by phasing out kerosene lamps, and pushing biofuel using households towards Liquefied Petroleum Gas (LPG) usage. In this study, we use updated emission inventories and trends in residential fuel consumption, to explore changes in the contribution of different sectors towards India's largest air pollution problem. We find that residential fuel usage is still the largest air pollution source, and that the <10% households using cow dung as cooking fuel contribute ∼50% of the residential PM₂.₅ emissions. However, if current trends persist, residential biofuel usage in India is likely to be phased out by 2035. India's renewable energy policies are likely to reduce emissions in the heat and electricity sector, and manufacturing industries, in the mid-term. PM₂.₅ emissions from open waste burning, on the other hand, hardly changed in the decade from 2010 to 2020. We conclude that without strong policies to promote recycling and upcycling of non-biodegradable waste, and the conversion of biodegradable waste to biogas, open waste burning is likely to become India's largest source of air pollution by 2035. While our study is limited to India, our findings are of relevance for other countries in the global South suffering from similar waste management challenges.

Indoor air quality ((IAQ) in classrooms was associated with the daily exposure of school-age children who are particularly vulnerable to air pollutants exposure, while few data exist to evaluate classroom indoor air quality nationwide in China. The subsample of the CIEHS 2018 study was performed in 66 classrooms of 22 primary schools nationwide in China. Temperature, relative humidity, PM₂.₅, PM₁₀, CO₂, CO, formaldehyde concentrations, bacteria and fungi were detected in all classrooms by using the instruments that meet the specified accuracy. The ratios of indoor to outdoor (I/O) of PM₂.₅ were calculated in each classroom to identify whether the indoor environment the pollutants comes from outdoors. The indoor PM₂.₅, PM₁₀, CO, HCHO, bacteria and fungi GM concentration are 47.40 μg/m³, 72.91 μg/m³, 0.37 mg/m³, 0.02 mg/m³, 347.51 CFU/m³ and 362.76 CFU/m³, respectively. We observed that there were 66.5%, 52.6%, 22.4%, 1.8%, and 9.6% of the classrooms that exceeded the guideline values of PM₂.₅, PM₁₀, CO₂, HCHO, and bacteria, respectively. It should be attention that all of the classroom's PM₂.₅ concentrations in Shijiazhuang and Nanning, PM₁₀ concentrations in Nanning, CO₂ concentration in Lanzhou were exceeded the suggested values. Bacteria contamination in Shijiazhuang's classrooms is also serious. All classroom CO concentrations meet the requirement. The results indicated that classroom indoor PM₂.₅ was significantly positively correlated with indoor PM₁₀ and CO₂, while was negative correlated with temperature, CO, and fungi. Our results suggest that indoor air pollution in classrooms was a severe problem in Chinese primary schools. It is necessary to strengthen ventilation in the classroom to improve indoor air quality. What's more, a healthy learning environment should be created for primary school students.

Dichloromethane (DCM) is a volatile halogenated hydrocarbon with teratogenic, mutagenic and carcinogenic effects. Biodegradation is generally regarded as an effective and economical approach of pollutant disposal. In this study, a novel strain was isolated and its cytochrome P450 was heterologously expressed for DCM degradation. The isolate, Microbacterium keratanolyticum ZY, was characterized as a Gram-positive, rod-shaped and flagella-existed bacterium without spores (GenBank No. SUB8814364; CCTCC M 2019953). After successive whole-genome sequencing, assembly and annotation, eight identified functional genes (encoding cytochrome P450, monooxygenase, dehalogenase and hydrolase) were successfully cloned and expressed in Escherichia coli BL21 (DE3). The recombinant strain expressing cytochrome P450 presented the highest degradation efficiency (90.6%). Moreover, the specific activity of the recombinant cytochrome P450 was more than 1.2 times that of the recombinant dehalogenase (from Methylobacterium rhodesianum H13) under their optimum conditions. The kinetics of DCM degradation by recombinant cytochrome P450 was well fitted with the Haldane model and the value of maximum specific degradation rate was determined to be 0.7 s⁻¹. The DCM degradation might occur through successive hydroxylation, dehydrohalogenation, dechlorination and oxidation to generate gem-halohydrin, formyl chloride, formaldehyde and formic acid. The study helps to comprehensively understand the DCM dechlorination process under the actions of bacterial functional enzymes (cytochrome P450 and dehalogenase).

There is growing evidence that the very presence of human beings in an enclosed environment can impact air quality by affecting the concentrations of certain airborne volatile organic compounds (VOC). This influence increases considerably when humans perform different activities, such as using toiletries, or simply eating and drinking. To understand the influence of these parameters on the concentrations of selected airborne constituents, a study was performed under simulated residential conditions in an environmentally-controlled exposure room. The human subjects either simply remained for a certain time in the exposure room, or performed pre-defined activities in the room (drinking wine, doing sport, using toiletries, and preparation of a meal containing melted cheese). The impact of each activity was assessed separately using our analytical platform and exposure room under controlled environmental conditions. The results showed that prolonged human presence leads to increased levels of isoprene, TVOCs, formaldehyde and, to a lesser extent, acetaldehyde. These outcomes were further supported by results of meta-analyses of data acquired during several internal studies performed over two years. Furthermore, it was seen that the indoor concentrations of several of the selected constituents rose when the recreational and daily living activities were performed. Indeed, an increase in acetaldehyde was observed for all tested conditions, and these higher indoor levels were especially notable during wine-drinking as well as cheese meal preparation. Formaldehyde increased during the sessions involving sport, using toiletries, and cheese meal preparation. Like acetaldehyde, acrolein, crotonaldehyde and particulate matter levels rose significantly during the cheese meal preparation session. In conclusion, prolonged human residence indoors and some recreational and daily living activities caused substantial emissions of several airborne pollutants under ventilation typical for residential environments.

Household air pollution is the dominant contributor to population air pollutant exposure, but it is often of less concern compared with ambient air pollution. One of the major knowledge gaps in this field are detailed quantitative source contributions of indoor pollutants, especially for gaseous compounds. In this study, temporally, spatially, and vertically resolved monitoring for typical indoor gases including CO₂, CO, formaldehyde, methane, and the total volatile organic compounds (VOCs) was conducted to address pollution dynamics and major sources in an urban apartment. The indoor concentrations were significantly higher than the simultaneously measured outdoor concentrations. A new statistic approach was proposed to quantitatively estimate contributions of different sources. It was estimated that outdoor CO₂ contributed largely to the indoor CO₂, while main indoor sources were human metabolism and cooking. Outdoor infiltration and cooking contributed almost equally to the indoor CO. The contribution of outdoor infiltration to methane was much higher than that to formaldehyde. Cooking contributed to 24%, 19%, and 25% of indoor formaldehyde, methane, and VOCs, whereas the other unresolved indoor sources contributed 61%, 19%, and 35% of these pollutants, respectively. Vertical measurements showed that the uplifting of hot air masses led to relatively high concentrations of the pollutants in the upper layer of the kitchen and in the other rooms to a lesser extent.

Isoprene, formaldehyde and acetaldehyde are important reactive organic compounds which strongly impact atmospheric oxidation processes and formation of tropospheric ozone. Monsoon meteorology and the topography of Himalayan foothills cause surface emissions to get rapidly transported both horizontally and vertically, thereby influencing atmospheric processes in distant regions. Further in monsoon, Indo-Gangetic Plain is a major rice growing region of the world and daytime hourly ozone can frequently exceed phytotoxic dose of 40 ppb O₃. However, the sources and ambient variability of these compounds which are potent ozone precursors are unknown. Here, we investigate the sources and photochemical processes driving their emission/formation during monsoon season from a sub-urban site at the foothills of the Himalayas. The measurements were performed in July, August and September using a high sensitivity mass spectrometer. Average ambient mixing ratios (±1σ variability) of isoprene, formaldehyde, acetaldehyde, and the sum of methyl vinyl ketone and methacrolein (MVK+MACR), were 1.4 ± 0.3 ppb, 5.7 ± 0.9 ppb, 4.5 ± 2.0 ppb, 0.75 ± 0.3 ppb, respectively, and much higher than summertime values in May. For isoprene these values were comparable to mixing ratios observed over tropical forests. Surprisingly, despite occurrence of anthropogenic emissions, biogenic emissions were found to be the major source of isoprene with peak daytime isoprene driven by temperature (r ≥ 0.8) and solar radiation. Photo-oxidation of precursor hydrocarbons were the main sources of acetaldehyde, formaldehyde and MVK+MACR. Ambient mixing ratios of all the compounds correlated poorly with acetonitrile (r ≤ 0.2), a chemical tracer for biomass burning suggesting negligible influence of biomass burning during monsoon season. Our results suggest that during monsoon season when radiation and rain are no longer limiting factors and convective activity causes surface emissions to be transported to upper atmosphere, biogenic emissions can significantly impact the remote upper atmosphere, climate and ozone affecting rice yields.

This study aimed to provide a comprehensive characterisation of the indoor air quality during the sleeping period of 10 couples at Lisbon dwellings, using a multi-pollutant approach, and to understand how the compliance with legislation and guidelines was to assure a good indoor air quality. The assessment of indoor air quality was conducted in the cold season using real time monitors during the sleeping period for comfort parameters (temperature and relative humidity) and air pollutants (carbon dioxide – CO₂, carbon monoxide – CO, formaldehyde – CH₂O, total volatile organic compounds – VOCs, and particulate matter – PM₂.₅ and PM₁₀), together with active sampling of bioaerosols (fungi and bacteria) before and after the sleeping period. Lower compliance (less than 50% of the cases) with the Portuguese legislation was found for temperature, CO₂ (3440 ± 1610 mg m⁻³), VOCs (1.79 ± 0.99 mg m⁻³) and both bioaerosol types. In 70% of the cases, PM₂.₅ (15.3 ± 9.1 μg m⁻³) exceeded the WHO guideline of 10 μg m⁻³. All bedrooms presented air change rates above the recommended minimum value of 0.7 h⁻¹, highlighting that a good indoor air quality during sleep is not guaranteed.

Seasonal and diurnal variations of carbonyl compounds were investigated in the ambient air of a mountainous city in China, from September 2014 to July 2015. The most abundant carbonyl compounds are formaldehyde, acetaldehyde and acetone, propionaldehyde and methacryladehyde (MACR), which were all measured in most samples. The average concentrations of formaldehyde, acetaldehyde, acetone, propionaldehyde and MACR in the atmosphere in Changsha were broken down into each season: 6.57, 3.29, 3.66, 0.67 and 0.54 μg/m³ respectively during Spring, 14.09, 8.28, 9.02, 1.28 and 0.6 μg/m³, respectively during Summer, 9.24, 5.48, 8.62, 0.73 and 0.62 μg/m³, respectively during Autumn, and 5.88, 4.84, 7.84, 0.87 and 0.26 μg/m³ respectively during Winter. And majority of the species had higher concentration during noon, showing photochemical oxidation and human activities played an important role in diurnal variation. The highest average C1/C2 (formaldehyde/acetaldehyde) ratio was observed in summer (2.10) compared to those (1.33–2.03) in other seasons, implying the photochemical activities had a positive effect on increasing the ratio of C1/C2. In this study, the monthly concentration of formaldehyde produced from isoprene accounts for 4.8%–39.1% of formaldehyde in ambient air. Strong correlation among some carbonyl compounds means that they came from the same sources. Photochemical reaction was the main source of carbonyl compounds in summer and vehicular exhaust (gasoline and diesel engines) in winter. Changsha is not a completely urbanized city and it is rich in vegetation of broadleaf evergreen shrubs. Both atmospheric photochemical reactions and anthropogenic sources, including vehicular exhaust and industrial processes, dominate the levels of carbonyls. The ILTCR and HQ values of formaldehyde and acetaldehyde are 1.23E-04 and 1.34E-05, 2.80E-01 and 1.86E-01, respectively.