Consumption of polythene is unavoidable in this era and it is increasing day by day. Polythene’s hazardous waste is adversely effecting environment. In fact any form of polythene is a nuisance to the environment because of strong resistance against degradation thus; they remain in nature for a very long time. Biodegradation is the only promising solution to overcome this problem.  Fungi, a group of saprophytic organisms are evolved to adapt for almost every environment, specially marine and freshwater source. This property drives fungi to grown on polythene even in adverse environment. So, present study was planned to compare biological degradation of low density polythene [LDPE] and biodegradable polythene by potential fungus to find out an eco-friendly and economic solution of polythene waste. Ten fungal strains were isolated from rotting polythene debris those are Penicillium chrysogenum, Rhizopus nigricans, Chaetomium murorum, Memnoniella echinata, Aspergillus fumigatus, Stachybotrys chartarum, Aspergillus niger, Chaetomium globosum, Aspergillus flavus and Fusarium oxysporum, in which Penicillium chrysogenum, Rhizopus nigricans, Aspergillus fumigatus, Aspergillus niger and Aspergillus flavus showed greatest results in terms of degrading both Low density polythene and biodegradable polythene. These isolates also showed good enzymatic reaction and weight loss. SEM analysis of polythene surface was also in support of these findings.