Numerous scientific publications have stirred a political debate about the impact of synthetic chemicals on the endocrine system of humans and animals. In an parliamentary inquiry, the Federal Government of Germany was requested to give its opinion on currently available information, to describe the measures taken so far and to outline the challenges for the future.The government’s reply — an abridged, translated version is published here — reviews crucial aspects of the present scientific debate. The main focus is on the critical examination of the request for immediate legal action (e.g. restricting the production or use of certain substances) to reduce exposure to endocrine disruptors. Furthermore, an overview is given on national and international measures taken so far to refine the assessment of the potential hazards emanating from these chemicals, to gain more insight into the underlying biological mechanisms and to improve the basis for targeted and adequate legal action.