The main geological landform in southwest China is karst, and hydrological resources in the region are rich. The water resources in this region cannot be efficiently and rationally used due to the complex topography and difficulty in developing water resources, which has led to problems such as desertification and soil erosion. The most typical area of karst landforms is in Guizhou Province. A water management method for an interconnected river system network is proposed, taking Guiyang as an example. This study provides a foundation for China’s South-to-North Water Diversion Project and can improve socioeconomic conditions in China.