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The minimum detectable difference (MDD) and the interpretation of treatmentr related effects of pesticides in experimental ecosystems
2015
Brock, T.C.M. | Hammers-Wirtz, M. | Hommen, U. | Preuss, T.G. | Ratte, H.T. | Roessink, I. | Strauss, T. | Brink, van den, P.J.
In the European registration procedure for pesticides, microcosm and mesocosm studies are the highest aquatic experimental tier to assess their environmental effects. Evaluations of microcosm/mesocosm studies rely heavily on no observed effect concentrations (NOECs) calculated for different population-level endpoints. Ideally, a power analysis should be reported for the concentration–response relationships underlying these NOECs, as well as for measurement endpoints for which significant effects cannot be demonstrated. An indication of this statistical power can be provided a posteriori by calculated minimum detectable differences (MDDs). The MDD defines the difference between the means of a treatment and the control that must exist to detect a statistically significant effect. The aim of this paper is to expand on the Aquatic Guidance Document recently published by the European Food Safety Authority (EFSA) and to propose a procedure to report and evaluate NOECs and related MDDs in a harmonised way. In addition, decision schemes are provided on how MDDs can be used to assess the reliability of microcosm/mesocosm studies and for the derivation of effect classes used to derive regulatory acceptable concentrations. Furthermore, examples are presented to show how MDDs can be reduced by optimising experimental design and sampling techniques.
Show more [+] Less [-]An expert support model for in situ soil remediation
2000
Okx, J.P. | Stein, A.
Multitracer study on absorption of radionuclides in atmosphere-plant model system
1998
Shinonaga, T. (Institute of Physical and Chemical Research, Wako, Saitama (Japan). Nuclear Chemistry Lab.) | Ambe, S.
Base cation supply in spruce and beech ecosystems of the Strengbach catchment (Vosges mountains, N-E France)
1998
Fichter, J. (Equipe Cycles Biogeochimiques de l'Unite Ecosystemes Forestiers INRA, Champenoux (France).) | Dambrine, E. | Turpault, M.P. | Ranger, J.
Assessing Se cycling and toxicity in aquatic ecosystems
1991
Porcella, D.B. (Electric Power Research Inst., Palo Alto, CA (USA)) | Bowie, G.L. | Sanders, J.G. | Cutter, G.A.
A model framework for assessing the effects of selenium on aquatic ecosystems
1991
Bowie, G.L. (Tetra Tech Inc., Lafayette, CA (USA)) | Grieb, T.M.
Modeling study of SO(x) and NO(x) transport during the January 1985 smog episode
1990
Leeuw, F.A.A.M. de (Rijksinstituut voor Volksgezondheid en Milieuhygiene, Bilthoven (Netherlands)) | Rheineck Leyssius, H.J. van
Defluoridation of water by adsorption on fly ash
1990
Chaturvedi, A.K. (Banaras Hindu Univ., Varanasi (India). Dept. of Applied Chemistry) | Yadava, K.P. | Pathak, K.C. | Singh, V.N.
Modelling of throughfall chemistry and indirect measurement of dry deposition
1986
Johannes, A.H. (Oklahoma State Univ., Stillwater (USA). School of Chemical Engineering) | Chen, Y.L. | Dackson, K. | Suleski, T.
The distribution of pollutants near a frontal surface: a comparison between field experiment and modelling
1986
Banic, C.M. (Atmospheric Environment Service, Downsview, Ont. (Canada)) | Isaac, G.A. | Cho, H.R. | Iribarne, J.V.
