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Ecological risk assessment of mixtures of radiological and chemical stressors: Methodology to implement an msPAF approach
2017
Beaumelle, Léa | Della Vedova, Claire | Beaugelin-Seiller, Karine | Garnier-Laplace, Jacqueline | Gilbin, Rodolphe
A main challenge in ecological risk assessment is to account for the impact of multiple stressors. Nuclear facilities can release both radiological and chemical stressors in the environment. This study is the first to apply species sensitivity distribution (SSD) combined with mixture models (concentration addition (CA) and independent action (IA)) to derive an integrated proxy of the ecological impact of combined radiological and chemical stressors: msPAF (multisubstance potentially affected fraction of species). The approach was tested on the routine liquid effluents from nuclear power plants that contain both radioactive and stable chemicals. The SSD of ionising radiation was significantly flatter than the SSD of 8 stable chemicals (namely Cr, Cu, Ni, Pb, Zn, B, chlorides and sulphates). This difference in shape had strong implications for the selection of the appropriate mixture model: contrarily to the general expectations the IA model gave more conservative (higher msPAF) results than the CA model. The msPAF approach was further used to rank the relative potential impact of radiological versus chemical stressors.
Show more [+] Less [-]Antimicrobial activity of pharmaceutical cocktails in sewage treatment plant effluent – An experimental and predictive approach to mixture risk assessment
2017
Menz, Jakob | Baginska, Ewelina | Arrhenius, Åsa | Haiß, Annette | Backhaus, Thomas | Kümmerer, Klaus
Municipal wastewater contains multi-component mixtures of active pharmaceutical ingredients (APIs). This could shape microbial communities in sewage treatment plants (STPs) and the effluent-receiving ecosystems. In this paper we assess the risk of antimicrobial effects in STPs and the aquatic environment for a mixture of 18 APIs that was previously detected in the effluent of a European municipal STP. Effects on microbial consortia (collected from a separate STP) were determined using respirometry, enumeration of culturable microorganisms and community-level physiological profiling. The mixture toxicity against selected bacteria was assessed using assays with Pseudomonas putida and Vibrio fischeri. Additional data on the toxicity to environmental bacteria were compiled from literature in order to assess the individual and expected joint bacterial toxicity of the pharmaceuticals in the mixture. The reported effluent concentration of the mixture was 15.4 nmol/l and the lowest experimentally obtained effect concentrations (EC10) were 242 nmol/l for microbial consortia in STPs, 225 nmol/l for P. putida and 73 nmol/l for V. fischeri. The lowest published effect concentrations (EC50) of the individual antibiotics in the mixture range between 15 and 150 nmol/l, whereas 0.9–190 μmol/l was the range of bacterial EC50 values found for the non-antibiotic mixture components. Pharmaceutical cocktails could shape microbial communities at concentrations relevant to STPs and the effluent receiving aquatic environment. The risk of antimicrobial mixture effects was completely dominated by the presence of antibiotics, whereas other pharmaceutical classes contributed only negligibly to the mixture toxicity. The joint bacterial toxicity can be accurately predicted from the individual toxicity of the mixture components, provided that standardized data on representative bacterial strains becomes available for all relevant compounds. These findings argue for a more sophisticated bacterial toxicity assessment of environmentally relevant pharmaceuticals, especially for those with a mode of action that is known to specifically affect prokaryotic microorganisms.
Show more [+] Less [-]The burden of ambient air pollution on years of life lost in Wuxi, China, 2012–2015: A time-series study using a distributed lag non-linear model
2017
Zhu, Jingying | Zhang, Xuhui | Zhang, Xi | Dong, Mei | Wu, Jiamei | Dong, Yunqiu | Chen, Rong | Ding, Xinliang | Huang, Chunhua | Zhang, Qi | Zhou, Weijie
Ambient air pollution ranks high among the risk factors that increase the global burden of disease. Previous studies focused on assessing mortality risk and were sparsely performed in populous developing countries with deteriorating environments. We conducted a time-series study to evaluate the air pollution-associated years of life lost (YLL) and mortality risk and to identify potential modifiers relating to the season and demographic characteristics. Using linear (for YLL) and Poisson (for mortality) regression models and controlling for time-varying factors, we found that an interquartile range (IQR) increase in a three-day average cumulative (lag 0–2 day) concentrations of PM2.5, PM10, NO2 and SO2 corresponded to increases in YLL of 12.09 (95% confidence interval [CI]: 2.98–21.20), 13.69 (95% CI: 3.32–24.07), 26.95 (95% CI: 13.99–39.91) and 24.39 (95% CI: 8.62–40.15) years, respectively, and to percent increases in mortality of 1.34% (95% CI: 0.67–2.01%), 1.56% (95% CI: 0.80–2.33%), 3.36% (95% CI: 2.39–4.33%) and 2.39% (95% CI: 1.24–3.55%), respectively. Among the specific causes of death, cardiovascular and respiratory diseases were positively associated with gaseous pollutants (NO2 and SO2), and diabetes was positively correlated with NO2 (in terms of the mortality risk). The effects of air pollutants were more pronounced in the cool season than in the warm season. The elderly (>65 years) and females were more vulnerable to air pollution. Studying effect estimates and their modifications by using YLL to detect premature death should support implementing health risk assessments, identifying susceptible groups and guiding policy-making and resource allocation according to specific local conditions.
Show more [+] Less [-]Development of electrostatic-based bioavailability models for interpreting and predicting differential phytotoxicity and uptake of metal mixtures across different soils
2017
Qiu, Hao | He, Erkai
Metals are ubiquitous and normally co-occur as mixtures in soil, but there remains much to do regarding the development of appropriate models which incorporate mixture interactions and bioavailability to estimate their phytotoxicity and phytoaccumulation. Here, we developed a probability-based electrostatic toxicity model (ETM) and a Langmuir-type electrostatic uptake model (EUM) to predict and normalize toxicity and uptake of zinc-copper mixtures in Hordeum vulgare L. in different soils. For model development, the electrical potential (ψ0) and metal ion activities ({M2+}0) at the cell-membrane surface was computed based on plant physiological properties and soil solution chemistry. Single metal toxicity correlated more closely to their corresponding {M2+}0 than to ion activities in soil solution or total soil metal concentrations. The ETM explained up to 89% of the variance in mixture toxicity across different soils. Incorporation of ψ0 into the EUM improved the model's ability for predicting metal uptake. Besides, cell-surface H+ appeared to significantly inhibit copper uptake via competition or other mechanisms, beyond its effect upon ψ0. Our results for the first time demonstrate that electrostatic theory can be used to predict and reconcile mixture toxicity and uptake data in different soils, indicating the potential of electrostatic-based models in risk assessment of multimetal-contaminated soils.
Show more [+] Less [-]Baseline tissue concentrations of metal in aquatic oligochaetes: Field and laboratory approaches
2017
Méndez-Fernández, Leire | Martinez-Madrid, Maite | Pardo, Isabel | Rodríguez, Pilar
Metal tissue residue evaluation in benthic macroinvertebrates is an important component of an integrated approach to ecological risk assessment of metals and metalloids in the Nalón River basin (North Spain), where historic mining activities took place. The purpose of this study was to know the baseline tissue concentration of 7 metals (Cd, Cu, Cr, Hg, Ni, Pb, and Zn) and one metalloid (As) in aquatic oligochaetes, sediment burrower organisms, representative of the collector-gatherer functional feeding group in the macroinvertebrate community. Metal concentration was measured in sediment and field aquatic oligochaetes at several reference (minimally disturbed) sites of the Nalón River basin, selected following Water Framework Directive criteria. Metal tissue residues were measured separately in field microdriles and lumbricids and compared with tissue concentrations measured in the aquatic oligochaete Tubifex tubifex exposed to reference sediments from the Nalón and other Cantabrian River basins in 28-d chronic laboratory bioassays. Metal tissue residues in bioassay organisms attained usually higher levels than in field worms, in special for As, Cu, Hg and Zn, although metal levels were within the same order of magnitude. The baseline values for metals were calculated from 90th percentile (P90) values in field aquatic oligochaetes (microdriles and lumbricids). The P90 for Hg, As and Zn could efficiently discriminate Toxic and Non-Toxic sites, while baseline values calculated for the other metals deserve further research due either to the low range of values found in the present study, or to the regulation of the metal body concentration, as in the case of Cu.
Show more [+] Less [-]Evidence of low dose effects of the antidepressant fluoxetine and the fungicide prochloraz on the behavior of the keystone freshwater invertebrate Gammarus pulex
2017
De Castro-Català, N. | Muñoz, I. | Riera, J.L. | Ford, A.T.
In recent years, behavior-related endpoints have been proposed as rapid and reliable ecotoxicological tools for risk assessment. In particular, the use of detritivores to test the toxicity of pollutants through feeding is currently becoming a well-known method. Experiments combining feeding with other behavioral endpoints can provide relevant information about direct and indirect toxicological effects of chemicals. We carried out a feeding experiment with the shredder Gammarus pulex in order to detect indirect (through leaf conditioning) and direct effects (through water exposure) of two pollutants at environmentally relevant concentrations: the fungicide prochloraz (6 μg/L) and the antidepressant fluoxetine (100 ng/L). Prochloraz inhibited fungal growth on leaves, but it did not affect either the microbial breakdown rates or the C:N ratio of the leaves. Individuals of G. pulex that were fed with treated leaves presented lower consumption rates, not only those fed with prochloraz-treated leaves, but also those fed with fluoxetine-treated leaves, and those fed with the mixture-treated leaves. Mixed-effects models revealed that the swimming velocity of the amphipods after the experiment was modulated by the exposure to fluoxetine, and also by the exposure to prochloraz. We demonstrate that both the antidepressant and the fungicide may cause significant sublethal effects at low concentrations. The combination of behavioral endpoints together with the application of mixed models provided a useful tool for early detection of the effects of toxicity mixtures in freshwater ecosystems.
Show more [+] Less [-]Photo- and thermo-chemical transformation of AgCl and Ag2S in environmental matrices and its implication
2017
Yin, Yongguang | Xu, Wei | Tan, Zhiqiang | Li, Yanbin | Wang, Weidong | Guo, Xiaoru | Yu, Sujuan | Liu, Jingfu | Jiang, Guibin
AgCl and Ag2S prevalently exist in the environment as minerals and/or the chlorination and sulfidation products of ionic silver and elemental silver nanoparticles (AgNPs). In this work, we investigated the chemical transformation of AgCl and Ag2S under simulated sunlight (in water) and incineration (in sludge and simulated municipal solid waste, SMSW). In the presence of natural organic matter, AgCl in river water was observed to be transformed into AgNPs under simulated sunlight, while photo-reduction of Ag2S could not take place under the same experimental conditions. During the course of incineration, pure Ag2S was transformed into elemental silver while AgCl remained stable; however, both Ag2S in sludge and AgCl in SMSW can be transformed to elemental silver under incineration, evident by the results of X-ray absorption spectroscopy and scanning electron microscopy measurements. Incineration temperature played an important role in the transformation of Ag2S and AgCl into elemental silver. These results suggest that chemical transformations of Ag2S and AgCl into elemental silver could be a possible source of naturally occurring or unintentionally produced AgNPs, affecting the fate, transport, bioavailability and toxicity of silver. Therefore, it is necessary to include the contributions of this transformation process when assessing the risk of ionic silver/AgNPs and the utilization and management of incineration residues.
Show more [+] Less [-]Tetracyclines metal complexation: Significance and fate of mutual existence in the environment
2017
Pulicharla, Rama | Hegde, Krishnamoorthy | Brar, Satinder Kaur | Surampalli, Rao Y.
Concern over tetracyclines (TCs) complexation with metals in the environment is growing as a new class of emerging contaminants. TCs exist as a different net charged species depending on their dissociation constants, pH and the surrounding environment. One of the key concerns about TCs is its strong tendency to interact with various metal ions and form metal complexes. Moreover, co-existence of TCs and metals in the environment and their interactions has shown increased antibiotic resistance. Despite extensive research on TCs complexation, investigations on their antibiotic efficiency and pharmacological profile in bacteria have been limited. In addition, the current knowledge on TCs metal complexation, their fate and risk assessment in the environment are inadequate to obtain a clear understanding of their consequences on living systems. This indicates that vital and comprehensive studies on TCs-metal complexation, especially towards growing antibiotic resistance trends are required. This review summarizes the role of TCs metal complexation on the development of antibiotic resistance. Furthermore, impact of metal complexation on degradation, toxicity and the fate of TCs in the environment are discussed and future recommendations have been made.
Show more [+] Less [-]Effects of the summer holiday season on UV filter and illicit drug concentrations in the Korean wastewater system and aquatic environment
2017
Kim, Ki-yŏng | Ekpeghere, Kalu Ibe | Jeong, Hee-Jin | Oh, Jeong-Eun
Seasonal variations in the concentrations of eight ultraviolet (UV) filters and 22 illicit drugs including their metabolites in the Korean aquatic environment were investigated. Seawater samples from three beaches, water samples from two rivers, and influents and effluents from three wastewater treatment plants were analyzed. The UV filter concentrations in the seawater, river water, and effluent samples were 39.4–296, 35.4–117, and 6.84–51.1 ng L-1, respectively. The total UV filter concentrations in the seawater samples were 1.9–4.4 times higher at the peak of the holiday season than outside the peak holiday season. An environmental risk assessment showed that ethylhexyl methoxy cinnamate (EHMC) could cause adverse effects on aquatic organisms in the seawater at the three beaches during the holiday period. Seven of the 22 target illicit drugs including their metabolites were detected in the wastewater influent samples, and the total illicit drug concentrations in the influent samples were 0.08–65.4 ng L-1. The estimated daily consumption rates for cis-tramadol (Cis-TRM), methamphetamine (MTP), meperidine (MEP), and codeine (COD) were 25.7–118.4, 13.8–36.1, 1.36–12.6, and 1.75–8.64 mg d-1 (1000 people)−1, respectively. In popular vacation area, the illicit drug consumption rates (Cis-TRM, MTP and MEP) were 1.6–2.6 times higher at the peak of the summer holiday season than at the beginning of the summer.
Show more [+] Less [-]The enantioselective toxicity and oxidative stress of beta-cypermethrin on zebrafish
2017
Although the toxicity of beta-cypermethrin (beta-CYP) to aquatic organisms has become a significant concern in recent years, its enantioselective effects on non-target organisms is poorly understood. To investigate the enantioselective toxicity of beta-CYP on zebrafish, adult zebrafish were exposed to a series of isometric concentrations of four beta-CYP enantiomers and the beta-CYP racemate for 96 h. In addition, the activities of four antioxidant enzymes and the malondialdehyde (MDA) content in zebrafish liver and brain were tested after 15 and 30 days beta-CYP enantiomers and racemate exposure under environmentally relevant dosages (0.01 and 0.1 μg/L). According to the acute toxicity results, the 1R-cis-αS and 1R-trans-αS enantiomers were more lethal than 1S-cis-αR and 1S-trans-αR. At 0.1 μg/L, the 1R-cis-αS and 1R-trans-αS enantiomers, and the beta-CYP racemate could significantly induce a hepatic MDA content at 30 days post exposure (dpe), while only 1R-cis-αS caused brain lipid peroxidation. An apparent regulation of antioxidase levels was observed in zebrafish liver and brain after exposure to the 1R-cis-αS and 1R-trans-αS enantiomers, and the beta-CYP racemate. In contrast, no significant oxidative stress was observed in zebrafish exposed to 1S-cis-αR and 1S-trans-αR enantiomers under the test concentrations. This work demonstrated the occurrence of enantioselectivity in toxicity and oxidative stress of beta-CYP to adult zebrafish, which should be considered in environmental risk assessments.
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