This research investigates the potential of two Plant Growth-Promoting Bacteria (PGPB) strains, EP1-AS and EP1-BM, isolated from the halophyte Euphorbia prostrata, to enhance plant growth and provide abiotic stress resilience. The study addresses the urgent need for sustainable agricultural practices in the face of challenges like soil salinization and heavy metal contamination. The investigation comprehensively analyzes the heavy metal and salt tolerance of the PGPB strains, revealing their potential applications in promoting plant growth under adverse environmental conditions. The research further explores the impact of these PGPB strains on wheat plants subjected to varying concentrations of heavy metals and salts. Results indicate that both PGPB strains, especially EP1-BM, exhibit significant tolerance to heavy metals and salt stress. EP1-BM demonstrates remarkable resilience even under high concentrations of these stressors. The study extends its findings to in vitro testing on wheat plants, revealing the positive influence of PGPB strains on germination, shoot length, and root length in the presence of salt and heavy metals. This research underscores the significance of understanding plant-microbe interactions, particularly in the context of promoting sustainable agriculture in challenging environments. The identified resilience of PGPB strains, especially EP1-BM, suggests their potential application as bio-remediators and plant growth promoters in soils affected by salinity and heavy metal stress. The promising results observed will be followed-up field trials. They will highlight the translational potential of these PGPB strains, offering a novel avenue for developing biofertilizer formulations with a cautious approach to safety concerns. Overall, this study contributes valuable insights into harnessing the untapped potential of resilient plants and their associated microbial communities for sustainable agriculture. It addresses key global challenges outlined by the United Nations Sustainable Development Goals.