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Lipid responses to environmental perfluoroalkyl substance exposure in a Taiwanese Child cohort
2021
Lee, Sheng-Han | Tseng, Wei-Chen | Du, Zhi-Yi | Lin, Wan-Yu | Chen, Mei-Huei | Lin, Ching-Chun | Lien, Guang-Wen | Liang, Hao-Jan | Wen, Hui-Ju | Guo, Yue-Leon | Chen, Pau-Chung | Lin, Jingyu
Although recent epidemiologic studies have focused on some of the health effects of perfluoroalkyl substance (PFASs) exposure in humans, the associations between PFASs exposure and the lipidome in children are still unclear. The purpose of this study was to assess lipid changes in children to understand possible molecular events of environmental PFASs exposure and suggest potential health effects. A total of 290 Taiwanese children (8–10 years old) were included in this study. Thirteen PFASs were analyzed in their serum by high-performance liquid chromatography-tandem mass spectrometry (LC-MS). MS-based lipidomic approaches were applied to examine lipid patterns in the serum of children exposed to different levels of PFASs. LC coupling with triple quadrupole MS technology was conducted to analyze phosphorylcholine-containing lipids. Multivariate analyses, such as partial least squares analysis along with univariate analyses, including multiple linear regression, were used to analyze associations between s exposure and unique lipid patterns. Our results showed that different lipid patterns were discovered in children exposed to different levels of specific PFASs, such as PFTrDA, PFOS, and PFDA. These changes in lipid levels may be involved in hepatic lipid metabolism, metabolic disorders, and PFASs-membrane interactions. This study showed that lipidomics is a powerful approach to identify critical PFASs that cause metabolite perturbation in the serum of children and suggest possible adverse health effects of these chemicals in children.
Show more [+] Less [-]Traffic-related air pollution and endurance exercise: Characterizing non-targeted serum metabolomics profiling
2021
Cruz, Ramon | Pasqua, Leonardo | Silveira, André | Damasceno, Mayara | Matsuda, Monique | Martins, Marco | Marquezini, Mônica V. | Lima-Silva, Adriano Eduardo | Saldiva, Paulo H. N. (Paulo Hilário Nascimento) | Bertuzzi, Romulo
Although the exposure to traffic-related air pollution (TRAP) has emerged as one of main problem worldwide to inhabitants’ health in urban centers, its impact on metabolic responses during exercise is poorly understood. The aim of study was to characterize the profile of non-target serum metabolomics during prolonged exercise performed under TRAP conditions. Ten healthy men completed two 90 min constant-load cycling trials under conditions of either TRAP or filtered air. Experimental trials were performed in a chamber located on an avenue with a high volume of vehicle traffic. Blood samples were taken at 30 min, 60 min, and 90 min of exercise. Based on Nuclear Magnetic Resonance metabolomics, the non-target analysis was used to assess the metabolic profile. Twelve, 16 and 18 metabolites were identified as discriminants. These were: at 30 min of exercise, the coefficient of determination (R²) 0.98, the predictive relevance, (Q²) 0.12, and the area under the curve (AUC) 0.91. After 60 min of exercise: (R²: 0.99, Q²: 0.09, AUC: 0.94); and at 90 min of exercise (R²: 0.91, Q²: <0.01, AUC: 0.89), respectively. The discriminant metabolites were then considered for the target analysis, which demonstrated that the metabolic pathways of glycine and serine metabolism (p = 0.03) had been altered under TRAP conditions at 30 min of exercise; arginine and proline metabolism (p = 0.04) at 60 min of exercise; and glycolysis (p = 0.05) at 90 min of exercise. The present results suggest that exposure to TRAP during prolonged exercise leads to a significant change in metabolomics, characterized by a transitional pattern and lastly, impairs the glucose metabolism.
Show more [+] Less [-]Plasticizer contamination in the urine and hair of preschool children, airborne particles in kindergartens, and drinking water in Hong Kong
2021
Common plasticizers and their alternatives are environmentally ubiquitous and have become a global problem. In this study, common plasticizers (phthalates and metabolites) and new alternatives [bisphenol analogs, t-butylphenyl diphenyl phosphate (BPDP), and bisphenol A bis(diphenyl phosphate) (BDP)] were quantified in urine and hair samples from children in Hong Kong, drinking water (tap water/bottled water) samples, and airborne particle samples from 17 kindergartens in Hong Kong. The results suggested that locally, children were exposed to various plasticizers and their alternatives. High concentrations of BPDP and BDP were present in urine, hair, tap water, bottled water, and air particulate samples. The geometric mean (GM) concentrations of phthalate metabolites in urine samples (126–2140 ng/L, detection frequencies < 81%) were lower than those detected in Japanese and German children in previous studies. However, a comparison of the estimated daily intake values for phthalates in tap water [median: 10.7–115 ng/kg body weight bw/day] and air particles (median: 1.23–7.39 ng/kg bw/day) with the corresponding reference doses indicated no risk. Bisphenol analogs were detected in 15–64% of urine samples at GM concentrations of 5.26–98.1 ng/L, in 7–74% of hair samples at GM concentrations of 57.5–2390 pg/g, in 59–100% of kindergarten air samples at GM concentrations of 43.1–222 pg/m³, and in 33–100% of tap water samples at GM concentrations of 0.90–3.70 ng/L. A significant correlation was detected between the concentrations of bisphenol F in hair and urine samples (r = 0.489, p < .05). The estimated daily urinary excretion values of bisphenol analogs suggest that exposure among children via tap water intake and airborne particle inhalation in kindergartens cannot be ignored in Hong Kong.
Show more [+] Less [-]Contrasting seasonal variations of geochemistry and microbial community in two adjacent acid mine drainage lakes in Anhui Province, China
2021
Xin, Ruirui | Banda, Joseph Frazer | Hao, Chunbo | Dong, Huiyuan | Pei, Lixin | Guo, Dongyi | Wei, Pengfei | Du, Zerui | Zhang, Yi | Dong, Hailiang
Acid mine drainage (AMD) is generated by the bio-oxidation of sulfide minerals. To understand the AMD formation and evolution, it is necessary to determine the composition and variation of acidophilic community, and their role in AMD ecosystem. In this study, we compared seasonal variations of geochemistry and microbial composition of two adjacent AMD lakes with different formation histories in Anhui Province, China. Lake Paitu (PT) formed in 1970s near a mine dump and the pH was in the range of 3.01–3.16, with the lowest in spring and summer while the highest in winter. The main ions in PT were Al and SO₄²⁻, whereas Fe concentration was relatively low. The concentrations of these ions were the lowest in summer and the highest in winter. Lake Tafang (TF) formed in around 2013 in a pit was more acidic (pH 2.43–2.75), but the seasonal variation of pH was the same as PT. Compared with Lake PT, TF had higher Fe, lower Al and SO₄²⁻ concentrations, and showed no significant seasonal changes. Despite salient seasonal variations of prokaryotic composition in Lake PT, Ferrovum was the major iron-oxidizing bacterium in most seasons. Furthermore, Lake PT was also rich in heterotrophic bacteria (48.6 ± 15.9%). Both prokaryotic diversity and evenness of Lake TF were lower than PT, and chemolithotrophic iron-oxidizing bacteria (71.7 ± 25.4%) were dominant in almost all samples. Besides Ferrovum, more acid tolerant iron-oxidizer Leptospirillum and Acidithiobacillus were also abundant in Lake TF. Chlamydomonas was the major eukaryote in Lake PT and it flourished repeatedly at the end of December, causing an extremely high chlorophyll a concentration (587 μg/L) at one sampling site in 2016, which provided rich nutrients for heterotrophic bacteria. The main alga in Lake TF was Chrysonebula, but its concentration was low, apparently because of the strong acidity and dark red color of lake water.
Show more [+] Less [-]Linking pollution to biodiversity and ecosystem multifunctionality across benthic-pelagic habitats of a large eutrophic lake: A whole-ecosystem perspective
2021
Zhang, Weizhen | Shen, Ji | Wang, Jianjun
Biodiversity loss is often an important driver of the deterioration of ecosystem functioning in freshwater ecosystems. However, it is far from clear how multiple ecosystem functions (i.e., ecosystem multifunctionality, EMF) relate to biodiversity across the benthic-pelagic habitats of entire ecosystems or how environmental stress such as eutrophication and heavy metals enrichment might regulate the biodiversity-EMF relationships. Here, we explored the biodiversity and EMF across benthic-pelagic habitats of the large eutrophic Lake Taihu in China, and further examined abiotic factors underlying the spatial variations in EMF and its relationships with biodiversity. In our results, EMF consistently showed positive relationships to the biodiversity of multiple taxonomic groups, such as benthic bacteria, bacterioplankton and phytoplankton. Both sediment heavy metals and total phosphorus significantly explained the spatial variations in the EMF, whereas the former were more important than the latter. Further, sediment heavy metals mediated EMF through the diversity of benthic bacteria and bacterioplankton, while nutrients such as phosphorus in both the sediments and overlaying water altered EMF via phytoplankton diversity. This indicates the importance of pollution in regulating the relationships between biodiversity and EMF in freshwater environments. Our findings provide evidence that freshwater biodiversity loss among phytoplankton and bacteria will likely weaken ecosystem functioning. Our results further suggest that abiotic factors such as heavy metals, beyond nutrient enrichment, may provide relatively earlier signals of impaired ecosystem functioning during eutrophication process.
Show more [+] Less [-]A systematic review and ecological risk assessment for organic ultraviolet filters in aquatic environments
2021
Carve, Megan | Nugegoda, Dayanthi | Allinson, Graeme | Shimeta, Jeff
Organic ultraviolet filters (OUVFs) are used in a wide range of manufactured products including personal care (e.g. sunscreens) and plastic items. This review summarizes the available data regarding the toxic effects of OUVFs on marine and freshwater organisms and generates the predicted no-effect concentration (PNEC) values necessary for assessing ecological risk. Through a systematic search of the literature, 89 studies were identified and ecotoxicological data extracted. Collectively, these studies described toxicity testing with 39 OUVF from 10 structural classes, with derivatives of benzophenones (49%) and camphors (16%) most studied. There was a bias towards selecting freshwater species (61%), and evaluating single OUVF effects (87%) rather than OUVF mixtures. Short-term (acute) experimentation (58%) was marginally more common than long-term (chronic) testing (42%). Reproductive, developmental, genetic, and neurological toxicity were the most commonly identified effects in aquatic organism, and were associated with molecular interactions with steroid receptors, DNA, or the production of reactive oxygen species. Species sensitivity distribution and/or assessment factors were used to calculate PNECs for 22 OUVFs and the risk quotients for 12 OUVFs. When using maximum concentrations, high risk was observed for six OUVFs in marine environments (4-methylbenzylidene-camphor, octocrylene, padimate-O, benzophenone-1, and oxybenzone, ethylhexyl-4-methoxycinnamate), and for four OUVFs in freshwater environments (ethylhexyl-4-methoxycinnamate, octocrylene, avobenzone and oxybenzone). When using median concentrations, a risk to marine environments was observed for oxybenzone. The results of this review underline that there is limited knowledge of the pathological effects of OUVFs and their metabolites in aquatic environments, and this inhibits the development of informed water-quality guidelines.
Show more [+] Less [-]microRNA-146a-5p negatively modulates PM2.5 caused inflammation in THP-1 cells via autophagy process
2021
Shang, Yu | Liu, Qianyun | Wang, Lu | Qiu, Xinghua | Chen, Yingjun | An, Jing
Ambient fine particulate matter (PM₂.₅) can change the expression profile of microRNAs (miRs), which may play important roles in mediating inflammatory responses. The present study attempts to investigate the roles of miR-146a-5p in regulating cytokine expression in a human monocytic leukemia cell line (THP-1). Four types of PM₂.₅ extracts obtained from Beijing, China, were subjected to cytotoxic tests in THP-1 cells. These four PM₂.₅ extracts included two water extracts collected from non-heating and heating season (WN and WH), and two organic extracts from non-heating and heating season (DN and DH). Firstly, the four PM₂.₅ extracts caused cytotoxicity, oxidative stress responses, cytokine gene expressions and interleukin 8 (IL-8) release in THP-1 cells, with WH showing the highest cytotoxicity, WN showing the highest oxidative stress and inflammatory responses. Additionally, we observed expression of miR-146a-5p was significantly increased, with the maximal response of six folds in WN group. Cellular autophagy was initiated by PM₂.₅ indicated by related protein and gene expressions. Both RNA interference and autophagy inhibitor were applied to interrupt autophagy process in THP-1 cells. Autophagy dysfunction could alleviate IL-8 expression, suggesting autophagy process regulated cytokine expression and inflammatory response caused by PM₂.₅. A chemical inhibitor was applied to inhibit the function of miR-146a-5p, and then the expressions of IL-8 and autophagic genes were significantly aggravated. Meanwhile, two target genes of miR-146a-5p, interleukin-1 associated-kinase-1 (IRAK1) and tumor-necrosis factor receptor-associated factor-6 (TRAF6) were increased dramatically, which also played important roles in regulation of autophagy. These data suggested miR-146a-5p negatively modulated cytokine expression caused by PM₂.₅ via autophagy process through the target genes of IRAK1 and TRAF6. Our findings raised the concerns of the changes of miR expression profile and following responses caused by PM₂.₅.
Show more [+] Less [-]Oil spill trajectory modelling and environmental vulnerability mapping using GNOME model and GIS
2021
Balogun, Abdul-Lateef | Yekeen, Shamsudeen Temitope | Pradhan, Biswajeet | Wan Yusof, Khamaruzaman B.
This study develops an oil spill environmental vulnerability model for predicting and mapping the oil slick trajectory pattern in Kota Tinggi, Malaysia. The impact of seasonal variations on the vulnerability of the coastal resources to oil spill was modelled by estimating the quantity of coastal resources affected across three climatic seasons (northeast monsoon, southwest monsoon and pre-monsoon). Twelve 100 m³ (10,000 splots) medium oil spill scenarios were simulated using General National Oceanic and Atmospheric Administration Operational Oil Modeling Environment (GNOME) model. The output was integrated with coastal resources, comprising biological, socio-economic and physical shoreline features. Results revealed that the speed of an oil slick (40.8 m per minute) is higher during the pre-monsoon period in a southwestern direction and lower during the northeast monsoon (36.9 m per minute). Evaporation, floating and spreading are the major weathering processes identified in this study, with approximately 70% of the slick reaching the shoreline or remaining in the water column during the first 24 h (h) of the spill. Oil spill impacts were most severe during the southwest monsoon, and physical shoreline resources are the most vulnerable to oil spill in the study area. The study concluded that variation in climatic seasons significantly influence the vulnerability of coastal resources to marine oil spill.
Show more [+] Less [-]Aggregation and stability of sulfate-modified polystyrene nanoplastics in synthetic and natural waters
2021
Wang, Junyu | Zhao, Xiaoli | Wu, Aiming | Tang, Zhi | Niu, Lin | Wu, Fengchang | Wang, Fanfan | Zhao, Tianhui | Fu, Zhiyou
Nanoplastics (NPs) are becoming emerging pollutants of global concern. Understanding the environmental behavior of NPs is crucial for their environmental and human risk assessment. In this study, the aggregation and stability of polystyrene (PS) NPs were investigated under different hydrochemical conditions such as pH, salt type (NaCl, CaCl₂, Na₂SO₄), ionic strength (IS), and natural organic matter (NOM). The critical coagulation concentrations of PS NPs were determined to be 158.7 mM NaCl, 12.2 mM CaCl₂, and 80.0 mM Na₂SO₄. Ca²⁺ was more effective in destabilizing PS NPs, compared to Na⁺, owing to its stronger charge screening effect. In the presence of monovalent ions, NOM reduced aggregation through steric repulsion, whereas in the case of divalent ions, NOM induced aggregation through cation bridging. Initial and long-term stability studies demonstrated that, in waters with high IS and NOM content, NOM was the most significant factor affecting NPs aggregation. PS NPs would be highly suspended in all freshwaters, and even in wastewater, whereas they would aggregate rapidly and deposit in seawater. Finally, a statistical model was established to evaluate the hydrodynamic diameter of NPs in different waters. The results indicated the stability of PS NPs in natural aquatic environments and their potential for long-term transport.
Show more [+] Less [-]Quantitative and qualitative evaluation of plastic particles in surface waters of the Western Black Sea
2021
Pojar, Iulian | Kochleus, Christian | Dierkes, Georg | Ehlers, Sonja M. | Reifferscheid, Georg | Stock, Friederike
Microplastic abundances have been studied intensively in the last years in marine and freshwater environments worldwide. Though several articles have been published about the Mediterranean Sea, only few studies about the Black Sea exist. The Black Sea drains into the Mediterranean Sea and may therefore significantly contribute to the Mediterranean marine pollution. So far, only very few articles have been published about micro-, meso- and macroplastic abundances in the Western Black Sea. In order to fill this knowledge gap and to decipher the number of plastics on the water surface, 12 samples were collected from surface waters with a neustonic net (mesh size 200 μm) in the Black Sea close to the Danube Delta and the Romanian shore. Organic matter was digested and plastic particles were isolated by density separation. The results of visual inspection, pyrolysis GC-MS (for microplastics) and ATR-FTIR (for mesoplastics >5 mm) revealed an average concentration of 7 plastic particles/m³, dominated by fibers (∼76%), followed by foils (∼13%) and fragments (∼11%). Only very few spherules were detected. The polymers polypropylene (PP) and polyethylene (PE) dominated which is in line with other studies analyzing surface waters from rivers in Western Europe as well as in China. Statistical analyses show that the plastic concentration close to the mouth of the Danube River was significantly higher than at four nearshore regions along the Romanian and Bulgarian coastline. This could be explained by plastic inputs from the Danube River into the western part of the Black Sea.
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