Sustainable clinical trials involve conducting trials in a socially conscious and environmentally responsible manner. This involves considering the effects of clinical trials on the environment and the populations engaged in the studies. The pharmaceutical sector, particularly clinical research, is a large contributor to greenhouse gas emissions. The need for a legal framework considering the environmental impact of hundreds of global clinical trials cannot be overstated. Clinical trials’ carbon footprint is a complex subject that calls for cooperation from various parties, including researchers, trial sponsors, healthcare providers, and regulatory organizations. The waste generated during clinical trials, including packaging materials, laboratory supplies, and hazardous waste from the disposal of clinical samples, can adversely affect public health and the environment. Therefore, addressing this issue is essential to ensure that clinical trials are conducted in an environmentally and socially responsible manner. The purpose of this study is to discuss potential strategies to cut down on carbon emissions, discuss the challenges in setting up clinical trials in an environmentally sustainable way, and highlight the importance of a precautionary approach during the various phases of conducting clinical trials. Although there is limited research on greenhouse gas emissions generated by clinical trials, it is evident that more work needs to be done in this field.

This work aims to explore the impact of fulvic acid (FA) on denitrification within the purification process of sewage in the deep subsurface wastewater infiltration system (DSWIS). In the system, an organic glass column (height = 2.40 m; radius = 0.30 m) was filled with several layers of soil. Simulated domestic wastewater and extracted FA from landfill leachate were used in the experiments. It was found that before and after the addition of FA, COD, and NH4+-N were efficiently removed when a hydraulic load was 8 cm·d-1. Moreover, after FA addition, the removal efficiency of TN was enhanced from 67.74% to 78.01%. Organic matter transformation analysis indicated that in the under part, the shortage of carbon sources limited the denitrification prior to FA addition, resulting in a low TN removal efficiency. However, after adding FA, more FA-like substances were transferred into protein-like matters than before the addition of FA, which has helped produce more easily biodegradable organics for denitrification. So, the addition of FA could enhance the denitrification process in the system of DSWIS.

This study investigated the water quality and the organic pollution level of rivers in Cotabato City, specifically the Rio Grande de Mindanao, Matampay, Esteros, and Tamontaka rivers. The physicochemical characteristics of water in these rivers were determined in the laboratory, and the level of organic pollution was determined using Palmer’s algal pollution index. Water quality assessment showed that the dissolved oxygen (DO) in Matampay River and the biological oxygen demand (BOD) in Esteros River exceed the minimum standard set by the Department of Environment and Natural Resources (DENR) for water quality in class C rivers. Results also showed that there were thirty (30) algal genera belonging to twelve (12) classes were observed in Cotabato City rivers. Algal genera belonging to Chlorophyceae and Bacillariophyceae were found to be the most abundant in these rivers. Using Palmer’s algal pollution index, the Rio Grande de Mindanao showed a probability of high organic pollution, while the rest of the rivers indicated a lack of organic pollution. For a more thorough assessment of the Cotabato City rivers, it is advisable to consider more comprehensive measures, such as extending the sampling duration and expanding the number of sampling stations.

In this paper, greywater samples are collected from the kitchens of different types of buildings (residential and commercial) located in different districts within the city of Jeddah, Saudi Arabia. The collected samples are analyzed and compared with the potable water from the same region. The parameters investigated are pH, conductivity, total solids (TS), total dissolved solids (TDS), total suspended solids (TSS), total hardness, temporary hardness, permanent hardness, alkalinity, chloride, and biochemical oxygen demand (BOD). It was found that the amount of total suspended solids is very high in the greywater samples. It shows the presence of both temporary and permanent hardness. Their alkalinity values are greater than hardness. It may be due to the number, lifestyle, age of the occupants, presence of children, and social and cultural behavior of residents. The concentration of BOD level is very low, which shows that the greywater samples have lower concentrations of organic compounds. Design details of the greywater treatment plant are suggested based on the results of the analysis. This includes a screening chamber, grit chamber, settling tank, and filtration unit. The treated greywater is recommended for reuse for gardening, landscaping, and toilet flushing purposes.

A common heavy metal pollutant of water resources, copper (II), can cause serious health problems or even death. Over the past few years, several filamentous fungi strains have been isolated, identified, and tested for their ability to bio-adsorb heavy metals for potential use in the bio-remediation of copper from wastewater. In this study, variables, including the dosage of fungal pellets, temperature, pH, time, initial copper concentration, and agitation rate, were assessed to select the best conditions for the adsorption of copper by Dictyuchus sterile pellets. To identify the active groups responsible for metal adsorption, microscopic observations were made using a light microscope and scanning electron microscope. The copper adsorbent was then analyzed before and after adsorption using an atomic adsorption spectrophotometer and Fourier transform infrared spectroscopy. The ideal adsorption conditions were: fungal pellets with a wet weight of 1 g.L-1 at a temperature of 25°C, pH 5.5, the initial copper concentration of 100 ppm, and shaking at a speed of about 250 rpm for 72 h to achieve a removal efficiency rate of 95%. Copper adsorbed with the biomass of the fungal pellets was 57 mg.g-1. The use of fungal pellets would be a method that can be used to increase the surface area of adsorption and also is thought to be one of the most cost-effective ways to remove trace metals from polluted water.

Anaerobic digestion produces biogas which usually contains 60-70% of methane (CH4), 30-40% of carbon-di-oxide (CO2), and 10-2,000 ppm hydrogen sulfide (H2S). The concentration of H2S depends upon the type of substrate. H2S tends to corrode pipes and machines carrying them. The high concentrations of H2S present in biogas may adversely affect electricity generation. Hence, the removal of H2S and enrichment of biogas with CH4 is an essential step towards higher energy production. In the present study, the biological method of removing H2S using Thiobacillus sp. was demonstrated for a one cu.m anaerobic co-digestion (ACD) unit running on an organic fraction of municipal solid waste (OFMSW) and septage sludge. Initial lab scale studies were conducted by collecting the biogas generated from 1 cu.m digesters, and continuous experiments were optimized for the process parameters such as flow rate, the volume of medium with culture, time, the height of the column, column composition, etc. The raw biogas was purged in a liquid medium (LM) with a culture containing Thiobacillus sp. The studies with the LM containing Thiobacillus sp. culture showed a 68% removal of H2S in the first 8 min, and the saturation occurred at 75 min when the time-dependent experiment was studied. The smaller flow rate (0.48 L.min-1) and highest volume of culture (500 mL) showed better results than other parameters. The highest and average oxidation rates of sulfate were recorded as 39 and 40.3 ppm.sec-1, respectively, for 0.48 L.min-1 flow rate and 500 mL of the culture volume. In the column studies, a column containing cocopeat (CP) was studied for its efficiency in removing H2S. At a flow rate of 0.9 L.min-1, 25% adsorption was encountered and reached saturation at 90 min. The bed height of 9 inches with CP and plastic support (PS) showed a 20% H2S removal. The filling ratio of CP and PS (1:1) was the best ratio for proper gas passage with optimal time for adsorption/absorption. The kinetic, isotherm, and continuous models helped to understand the capacity of the adsorbent. Freundlich, Yoon-Nelson, and BDST model were best fit for the present study. A pilot scale setup for one cu.m biogas reactor showed an average of 50% removal of H2S for LM with culture, and an additional 20% removal was possible by the introduction of a column along with the liquid bed in series. An overall efficiency of 70-75% of H2S removal was achieved. No significant CH4 loss was encountered during the study.

As climate change continues to cause more frequent weather shocks such as droughts and floods and increasingly erratic rainfall, people in developing regions are threatened by crop failures and hunger. In this study, the researchers describe how climate change influences food security in Central Java, seen from the frequency of floods, rainfall, and rainy days. This study also added another variable, i.e., economic growth, reviewed through GRDP and the amount of rice production. Using the Common effect model, the study results revealed that rainy days and population were the variables significantly influencing food security in cities/regencies in Central Java Province. Meanwhile, two other variables, i.e., rainfall and GRDP, had no significant effect on food security in cities/regencies in Central Java Province.

Extreme floods have become common in Asian cities, with recent increases in urbanization and extreme rainfall driving increasingly severe and frequent events. Understanding the flood dynamic is essential for developing strategies to reduce risk and damage, thus ensuring the city’s protection. Channel roughness is a sensitive parameter in developing a hydraulic model for flood forecasting and flood inundation mapping. A High-resolution 2D HEC-RAS model was used to simulate the flood events of 1994, 1998, 2002, 2006, and 2015. The calibrated model, in terms of channel roughness, has been used to simulate the flood for the year 2006 in the river. The performance of the calibrated HEC-RAS-based model has been accessed by capturing the flood peaks of observed and simulated floods and computation of root mean squared error (RMSE) for the intermediated gauging stations on the lower Tapi River. Results revealed that there is good agreement between simulated and observed floods.

The COVID-19 first case was reported in India on January 30, 2020, and in Chhattisgarh on March 19, 2020, and since then a sharp surge has been noticed. The government of India imposed a nationwide lockdown on March 25, 2020, a complete suspension of human activities, viz., industry, construction, transport, academic institutions, etc., which resulted in an improvement in air quality (a decrease in PM2.5 and PM10, alteration in NO2 and an increase in O3). But the rate of cases of COVID-19 has increased sharply, and eventually, under economic pressure, the lockdown was withdrawn on June 1, 2020, which further accelerated the exponential growth of COVID-19 cases. We noticed that in the Chhattisgarh State of India, the alteration in the air quality index during the lockdown period is continuing even after the restoration of anthropogenic activities. Among PM2.5, PM10, NO2, and O3, the behavior of NO2 was found to be different than others; it was found to increase during the lockdown period but further decreased with the resumption of anthropogenic activities. We conclude that the air quality index has an insignificant impact on COVID-19 infection.

The water, food, and energy demands are the basic requirements of society. These demands are increasing daily due to an increase in population or lifestyle changes. To fulfill these ever-increasing demands, several water resource projects have come up which require the storage or diversion of river water. These interventions have caused widespread degradation of aquatic ecosystems. Due to the degradation of the aquatic ecosystem, several programs all around the globe began. In this series, Brisbane Declaration (2007) provided a more holistic definition of Environmental Flows (EFs) as the quantity, timing, duration, frequency, and quality of flows required to sustain freshwater, estuarine and near-shore ecosystems and the human livelihoods and well-being that depend on them. The present study was envisaged to assess for environmental flows of the Tawi river with a major objective of assessing the environmental flows of the Tawi river using the Global Environmental Flow Calculator developed by IWMI. The method provides E-Flows for different Environmental Management Classes. For the western Himalayan region, the river stretches in Environmental Management Class ‘B’ and ‘C’. The assessment provides E-Flows in two ways: (i) the percentage of Mean Annual Runoff and (ii) average monthly environmental flows. E-Flows were estimated as 42.34% to 56.96% of Mean Annual Runoff and varied from 5.73 cumecs during November to 68.23 during August.