A detailed study was conducted in order to evaluate the effects of heavy metal pollution in the sediments in terms of environmental, ecological, and human health. Sediment samples were collected from 5 different points in two seasons, namely summer (August 2017) and winter (December 2017), to determine the distribution of heavy metals, potential pollutants, and toxic and ecological risks in the river sediments in Samsun-Tekkeköy district located in the Mid-Black Sea Region of Turkey and to evaluate the human health risk. The distribution of heavy metals at the sampling points was Fe>Al>Mn>Zn>Cu>Cr>Ni>Pb>Cd based on their averages. According to the toxic risk index (TRI) results, sampling point OIZ (Organized Industrial Zone) Channel (T3) was also found to have a moderate risk, and it was determined that the highest contribution was from Cu>Ni>Cd>Cr, respectively. Potential ecological risk index (PERI) results revealed a low risk except for Cd metal at all sampling points. While the sediment enrichment factor (EF) did not show much metallization at many points, the highest enrichment was observed in Cd, Cu, and Zn metals at sampling point T3. According to the geoaccumulation index (Igₑₒ) and contamination factor (CF), sampling point T3 showed contamination with Cd, Cu, Cr, and Zn. Evaluation of human health risk showed that the hazard index (HI) results of carcinogenic and non-carcinogenic risks were higher among children than adults. The total lifetime cancer risks (TLCR) of heavy metals were within the limits determined by USEPA. However, the risk was ranked as Cr>Cd>Pb. Sediment quality guidelines (SQGs) and pollution index results showed that heavy metal contamination was due to anthropogenic and industrial activities since the region was an industrial zone. It was determined that heavy metals posed ecological risks and that the Samsun-Tekkeköy region was moderately and significantly contaminated.

The acoustical properties of a barrier are highly dependent on the physical properties of the material and the internal structure of the material. The acoustical material can curtail the quality of sound or enhance the dispersion, depending on the application being considered. The efficient acoustic performance of noise barriers possessing different shapes and materials including waste materials is reviewed for field implementation to achieve the low-cost sustainable noise barrier application in the Indian context. The review analysis of research papers demonstrates that the acoustic performance of barriers is dependent on different shapes, materials, and textures as well as onsite geometry. Based on the review study, T-shaped barriers with a soft top surface are found to be efficient at noise attenuation. For transparent barriers, perceived loudness and noise annoyance are assessed lower than that for opaque barriers and utilization of waste materials viz. plastic, rubber, bottom coal ash, etc. gives high noise attenuation along with low-cost efficiency. Noise pollution levels are high from prescribed noise limits in most of the Indian metropolitan cities. The Indian government is working on mitigation strategies of noise pollution as well as abiding laws regarding noise standards for the zone (residential, industrial, commercial, and silences) wise. In contrast, some communities which are adjacent to roads are suffering from high noise levels in the ambience. Therefore, it requires a coherent strategy for long-term measures intended at minimizing exposure of noise hence providing much more comfort to live, work, and shop near high-traffic roads. Noise barriers are highly beneficial in mitigating the emitted noise from the traffic.

As a contribution to the technological innovation-natural resource rent-environment literature, this study examines the technological innovation and natural resource rent in an environmental Kuznets curve (EKC) multivariate framework. We employed reliable, robust, and efficient novel panel estimations methods on a sample of 10 newly industrialized countries (NICs) over the periods 1990 and 2018. To achieve our study objective, we employ the method of moments quantile regression (MMQR) approach to analyze the effects of the exogenous variables over the range of diverse quantiles of carbon emissions. Results generated from the MMQR mimic that of the three heterogeneous linear panel estimations (fully modified ordinary least square, the dynamic ordinary least square, and the fixed effects ordinary least square) in terms of the sign and magnitude. The result affirms the existence of the environmental Kuznets curve (EKC) hypothesis in NICs across all quantiles (0.1–0.95). In addition, technological innovation and renewable energy consumption improve environmental quality in NICs across quantiles (0.1–0.95), while the joint impact of technological and natural resource rent mitigates environmental degradation from lower to higher quantiles (0.1–0.90). Moreover, technological innovation is found to exert an indirect favorable impact on the environment through the pathway of natural resources. Thus, technological innovation can be anticipated to enhance sustainable natural resources exploration in the NICs. In line with these crucial outcomes, this research proposes that the NICs should promote technological innovation, promote sustainable natural resource exploitation, and expedite economic expansion rates via the sustainable transformation of their production and consumption processes.

In the present study, toxic effects, both alone and combined, of bisphenol A (BPA), lead (Pb) and endosulfan (ES) in the low doses were investigated in rat liver and kidney functions. In the study, bisphenol A (BPA), lead (Pb) and endosulfan (ES) were chosen because although they are the chemicals people are most frequently exposed to, no combined toxic effect studies were conducted with these chemicals. Sixty-four male Wistar albino rats were used in the study, and they were randomly divided into eight groups (n = 8 per group); control, BPA (5 mg/kg), Pb (100 ppm), ES (0.61 mg/kg), BPA+Pb, BPA+ES, Pb+ES and BPA+P+ES. The rats were sacrificed after 65 days of treatment. Severe histopathological changes in the liver and kidney tissues were observed in the rats exposed to BPA+Pb+ES combination. Elevated malondialdehyde (MDA) in the liver and decreased superoxide dismutase activity (SOD) in the kidney tissue were detected in the BPA+Pb+ES group compared to those of the control group. It was found that serum alanine aminotransferase (ALT) and blood urea nitrogen (BUN) and creatinine (CREA) levels were higher in the BPA+Pb+ES combination group than the control group. Also, combined exposure of BPA, Pb and ES caused apoptotic cell numbers and inducible nitric oxide (iNOS) to increase in the liver and kidney tissues. The results of the present study suggested that the BPA, Pb and ES caused more dramatic changes to both histological architecture and cell apoptosis in the liver and kidney tissues when there was a combined exposure.

Mercury (Hg) is one of the most hazardous pollutants, due to its toxicity, biological magnification and worldwide persistence in aquatic systems. Thus, new efficient nanotechnologies (e.g. graphene oxide functionalized with polyethyleneimine (GO-PEI)) have been developed to remove this metal from the water. Aquatic environments, in particular transitional systems, are also subjected to disturbances resulting from climate change, such as salinity shifts. Salinity is one of the most relevant factors that influences the distribution and survival of aquatic species such as mussels. To our knowledge, no studies assessed the ecotoxicological impairments induced in marine organisms exposed to remediate seawater (RSW) under different salinity levels. For this, the focus of the present study was to evaluate the effects of seawater previously contaminated with Hg and remediated with GO-PEI, using the species Mytilus galloprovincialis, maintained at three different salinities (30, 20 and 40). The results obtained demonstrated similar histopathological and metabolic alterations, oxidative stress and neurotoxicity in mussels under RSW treatment at stressful salinity conditions (20 and 40) in comparison to control salinity (30). On the other hand, the present findings revealed toxicological effects including cellular damage and histopathological impairments in mussels exposed to Hg contaminated seawater in comparison to non-contaminated ones, at each salinity level. Overall, these results confirm the high efficiency of GO-PEI to sorb Hg from water with no noticeable toxic effects even under different salinities, leading to consider it a promising eco-friendly approach to remediate contaminated water.

Global warming and food security have led to increasing concern about agricultural crop production efficiency, especially wheat and rice farming. The purpose of the current study is to measure wheat and rice production efficiency scores with environmental quality in China, India, and Pakistan by using a data envelopment analysis (DEA) model. The DEA results show that China and India are more efficient in wheat and rice production but it is not efficient in the environment in the study period. The results also show that Pakistan has also relatively small wheat and rice efficiency compared with China and India and increased the efficiency with the passage of time. The practical outcomes also show that Pakistan has the most efficient and effective states from the periods 2008 to 2019 in terms of wheat and rice efficiency and also a small increase in carbon emission. Based on the findings, policymakers should pay attention to the role of green technology in reducing agricultural CO2 emissions.

Accurate and simple prediction of farmland groundwater level (GWL) is an important aspect of agricultural water management. A farmland GWL prediction model, GWPRE, was developed that integrates four machine learning (ML) models (support vector machine regression, random forest, multiple perceptions, and the stacking ensemble model) with weather forecasts. Based on the GWL and meteorological data of five monitoring wells (N1, N2, N3, N4, and N5) in Huaibei plain from 2010 to 2020, the feasibility of predicting GWL by meteorological factors and ML algorithm was tested. In addition, the stacking ensemble model and future meteorological data after Bayesian model averaging were introduced for the first time to predict GWL under future climate conditions. The results showed that GWL showed an increasing trend in the past decade, but it will decrease in the future. The performance of the stacking ensemble model was better than that of any single ML model, with RMSE reduced by 4.26 ~ 96.97% and the running time reduced by 49.25 ~ 99.40%. GWL was most sensitive to rainfall, and the sensitivity index ranged from 0.2547 to 0.4039. The fluctuation range of GWL of N1, N2, and N3 was 1.5 ~ 2.5 m in the next decade. Due to the possible high rainfall, the GWL decreased in 2024 under RCP 2.6 and 2026 under RCP 8.5. It is worth noting that although the stacking ensemble model can improve the accuracy, it is not always the best among ML models in terms of portability. Nevertheless, the stacking ensemble model was recommended for GWL prediction under climate change.

Ulcerative colitis (UC) is an idiopathic chronic inflammatory disorder mainly affecting the colon and rectum. The present investigation was undertaken to evaluate the potential protective effect of flavocoxid, a dual COX and LOX inhibitor, in colitis model in rats. UC was induced by instillation of 2 ml of 4% acetic acid (AA) into the colon using a pediatric catheter in rats, and flavocoxid (10 and 20 mg·kg⁻¹) was given once daily for 7 days before induction of colitis. Rats were sacrificed; sera were collected; colons and livers were isolated and then analyzed by biochemical, macroscopic, and histopathological examination. Pretreatment with flavocoxid (10 and 20 mg·kg⁻¹) significantly reduced serum levels of alanine transaminase (ALT) (43.7 ± 7 and 76.2 ± 7.3 vs. 288.7 ± 31.4 in AA group) and aspartate transaminase (AST) (179.5 ± 22.2 and 200.5 ± 14 vs. 392.7 ± 35.6 in AA group) (p>0.05). Also, it decreased malondialdehyde (MDA) and nitric oxide (NOx) levels in both colonic and hepatic tissues. Moreover, flavocoxid effectively elevated colonic and hepatic reduced glutathione (GSH) level and superoxide dismutase (SOD) activity when compared to AA group (p>0.05). Additionally, flavocoxid significantly decreased levels of tumor necrosis factor-α (TNF-α) (878.2 ± 13.4 and 560.1 ± 2.9 vs. 1378.1 ± 31 in AA group) in colonic tissues and (701 ± 6.9 and 442.5 ± 8.2 vs. 1501 ± 9.4 in AA group) in hepatic tissues, nuclear factor kappa B (NF-κBp65) (493.8 ± 6.8 and 368.7 ± 3.1 vs. 659.2 ± 9.4 in AA group) in colonic tissues and (358 ± 5.1 and 163.5 ± 7.8 vs. 732.5 ± 4.5 in AA group) in hepatic tissues, myeloperoxidase (MPO) (15.7 ± 0.3 and 13 ± 0.2 vs. 20.9 ± 0.5 in AA group) in colonic tissues and (20.4 ± 0.3 and 16.3 ± 0.3 vs. 23.9 ± 1.2 in AA group) in hepatic tissues, and inducible nitric oxide synthase (iNOS) (12.5 ± 0.3 and 10 ± 0.2 vs. 16 ± 0.1 in AA group) in colonic tissues and (14.1 ± 0.04 and 11.5 ± 0.08 vs. 17.8 ± 0.1 in AA group) in hepatic tissues (p>0.05). Furthermore, it down-regulated Bax and caspase-3 expression in colonic and hepatic tissues upon comparison with AA group. Collectively, flavocoxid conferred a protective impact against acetic acid-induced colitis in rats via attenuating oxidative stress, inflammation, and apoptosis.

The drive mode is an important factor that affects the adjustment requirements for emission factors of the conventional simulation methods in multi-story car parks. In order to propose comprehensive emission factor adjustments for passenger cars based on the drive modes, the present study is aimed to investigate the effects of different drive modes on emission factors for multi-story car parks. Thus, to achieve this aim, the tailpipe emissions based on the on-board measurement and international vehicle emission (IVE) model are obtained. The results indicate that the drive modes significantly affect the emissions. Accordingly, the change in drive mode from minimum to maximum leads to an increase in the vehicle-specific power (VSP) by 106%. Furthermore, the results of emission factors show the discrepancy between on-board measurement and IVE model with the maximum and minimum adjustment factors by 3.28 and 1.28 for carbon monoxide (CO) and carbon dioxide (CO₂), respectively.

The current study was designed to assess the in vivo hepatoprotective properties of trans-Anethole, which is a principal aromatic component of star anise. The hepatoprotective effects of trans-Anethole were evaluated at three doses [40, 80, and 160 mg/kg body weight (b.wt.)] against carbon tetrachloride (CCl₄)-induced hepatic damage in male Wistar rats for 4 weeks. Forty-two male Wistar rats were equally divided into seven groups; the control (group I) received only distilled water. Rats of group II received CCl₄ (1 ml/kg b.wt.) in a 1:1 ratio of CCl₄ and olive oil via intraperitoneal doses, while rats of group III received silymarin (50 mg/kg b.wt.), followed by CCl₄ intraperitoneal doses, 3 days in a week. Rats of group IV received trans-anethole (160 mg/kg b.wt.) for 28 days as a negative control. Trans-anethole at the doses of 40, 80, and 160 mg/kg b.wt. was administered to groups V, VI, and VII, respectively, for 28 days, followed by CCl₄ (i.p). Results showed that CCl₄ treatment (group II) elevated the levels of different serum markers like aspartate aminotransferase (AST) by 4.74 fold, alanine aminotransferase (ALT) by 3.47 fold, aspartate alkaline phosphatase (ALP) by 3.55 fold, direct bilirubin by 3.48 fold, and total bilirubin by 2.38 fold in contrast to control. Furthermore, it was found that the decreased levels of liver antioxidant enzymes viz. catalase (CAT) and glutathione reductase (GR) were significantly modulated by the pre-administration of rats with different doses (40, 80, and 160 mg/kg b.wt.) of trans-anethole. Furthermore, pre-treatment of trans-anethole reduced the level of phase I enzymes and elevated the level of phase II detoxifying enzymes. Histopathological investigations showed that the treatment with trans-anethole was effective in ameliorating CCl₄-induced liver injury and restored the normal hepatic architecture. Moreover, trans-anethole restored p53 and cyclin D levels in liver tissue relative to group II. Western blot analysis revealed that the trans-anethole treatment downregulated the expression of Bax and caspase-3 while upregulated the expression of Bcl-xL. Collectively, the findings of the study showed the strong efficacy of trans-anethole in ameliorating the hepatic damage caused by CCl₄ through the modulation of antioxidants and xenobiotic-metabolizing enzymes.