Rapid economic development in coastal areas has gradually increased the risk of coastal water quality deterioration. The assessment methods of coastal water quality are multifarious, but many depend on either subjective judgment or objective calculation. We proposed a weighted sum methodology by integrating the subjective analytic hierarchy process and objective entropy theory (AHP-entropy weight methodology) to obtain an overall evaluation of coastal water quality. The mathematical models to transform the biochemical and physical parameter values and soluble substance concentrations into index scores have been formulated in comparison to the national water quality classification scheme. The application of the AHP-entropy weight methodology was demonstrated in the nearshore area of Yangjiang city, China, based on 23 seawater sampling stations in autumn 2017 and spring 2018. Datasets including biochemical and physical parameters, nutrients, and heavy metals have been converted into water quality index scores based on the proposed mathematical model. Results revealed that the overall water quality fell into the “good” class in both sampling seasons. The spatial distribution of the water quality index scores demonstrated that the relatively worse water quality occurred in estuarine and nearshore areas, signifying the negative effect of coastal anthropogenic activities. The statistical analyses like the hierarchical cluster analysis interpreted that the river input acted as a main source of pollutants in the study area. The AHP-entropy weight methodology could be a preferred way to assist decision-makers in properly evaluating the current state of coastal water quality in an unbiased, objective manner.

Worldwide, nitrogen (N) deficiency is the main yield limiting factor owing to its losses via leaching and volatilization. Urease inhibitors slow down urea hydrolysis in soil by inhibiting urease enzyme activities whereas gibberellic acid is growth regulator. That is why, we evaluated the role of urease inhibitor [N-(n-butyl)thiophosphorictriamide (NBPT)] and gibberellic acid (GA₃) in improving nitrogen uptake and yield of maize under different N levels (120 and 150 kg ha⁻¹) along with control. Both N levels alone and in combination with GA₃ and NBPT significantly increased yield and yield components of maize over control. In addition, 150 kg N ha⁻¹ + NBPT + GA₃ produced highest biological, grain, and stover yields, 1000 grain weight, plant height, and N uptake exhibiting 33.15%, 56.46%, 27.56%, 19.56%, 23.24%, and 78% increase over 150 kg N ha⁻¹, respectively. The sole use of gibberellic acid or NBPT with each level of N also improved the yield and yield components of maize compared to sole N application and control. Furthermore, application of 120 kg N ha⁻¹ along with NBPT and GA₃ performed at par to 150 kg N ha⁻¹ + NBPT + GA₃ but it was superior than sole applied 150 kg N ha⁻¹ for all the studied traits. These results imply that application of GA₃ and/or NBPT can reduce dependence on urea and improve the yield and N uptake in maize by slowing urea hydrolysis in calcareous soils and shall be practiced.

In this contemporary era, wetlands and the entire aquatic diversity are suffering from major pollution problem. Not only the aggregation of higher population in metropolitan causes the production of plenty of solid, liquid and gaseous wastes, but also the high-technological industries contribute to a mammoth of wastes in the ecosystem. During the process of industrial effluent discharge into the water bodies, the toxic substances available in these wastes can affect the aquatic flora and fauna, resultantly disturbing the entire system and constituting human health hazards indirectly or directly. The objective of this study was to estimate the nutritional value of the liver and intestine of fish which is being discarded as waste during fish processing and pollution status by calculated water quality index (WQI) and comparison of both wetlands during diverse seasons. WQI of Harike Wetland was observed to be 56.68 which indicates that water quality in this wetland is “poor”, while at Nangal Wetland WQI was calculated to be 39.54 and comes under “good” water quality and safe for the entire ecosystem. HPI (heavy metal pollution index) for Harike Wetland was observed 144.9 and for Nangal Wetland was 3.12, indicating heavy load of heavy metal pollution at test sample site. MI (metal index) value was also detected higher at test sample site (4.76) as compared to that at control site (0.22). The mean total n-3 and n-6 polyunsaturated fatty acids (PUFAs) declined in the liver of test fish samples (Harike Wetland) as compared to control fish (Nangal Wetland) samples except in winter season. Similarly, mean total saturated fatty acids (SFAs) were also found to decline significantly (p<0.05) in the liver of test fish sample as compared to control fish sample during autumn and winter seasons. Significant (p<0.05) decline of mean total n-3 PUFAs (except winter) and total n-6 PUFAs (except rainy) in the intestine of test fish sample was observed during all the seasons when compared to control fish samples. However, total SFAs were found to increase in the intestine of test fish samples as compared to control fish samples during all the studied seasons. In the present investigation, fluctuations recorded in the water quality parameters and major groups of FAs in the tissues were due to the geographical location and pollution load in the fish samples taken from Harike Wetland.

In this study, the flower-shaped Bi₂S₃/g-C₃N₄-2.6 heterojunction obtained by solvothermal method and its photocatalytic degradation efficiency of rhodamine B (RhB) and tetracycline (TC) in aqueous solution within 40 min is as high as 98.8% and 94.6%. For RhB degradation, the photocatalytic reaction rate constant (k) of Bi₂S₃/g-C₃N₄-2.6 is approximately 1.8 and 45.5 times that of Bi₂S₃ and g-C₃N₄. For TC, k is 3.1 and 2.4 times that of Bi₂S₃ and g-C₃N₄, respectively. The key to determining the high catalytic activity of Bi₂S₃/g-C₃N₄ lies in the formation of a good heterojunction between Bi₂S₃ and g-C₃N₄, which accelerates the electron transfer rate between the heterojunction interface and effectively avoids electron–hole recombination. The effects of catalyst dosage, different pH values, inorganic anions, and capture agents on the photodegradation performance of RhB were investigated. The results show that the catalyst dosage is 1.33 g/L, and the solution pH is in the range of 5–9, which has the best removal effect on pollutants, and the isolation of holes (h⁺) with strong oxidizing ability promotes the collapse of pollutant molecules. Combined with electrochemical tests, a possible degradation mechanism was advised.

Co-digestion between sugarcane vinasse (Vn) and water hyacinth (WH) at various mixing ratios of 0:1, 1:0, 1:3, 3:1, and 1:1 was carried out under thermophilic conditions (55 °C) for 60 days. The effect of various mixing ratios on the pH changes, soluble chemical oxygen demand (sCOD) reduction, and cumulative biogas production was investigated. The first order, modified Gompertz, and logistic function kinetic models were selected to fit the experimental data. Model discrimination was conducted through the Akaike Information Criterion (AIC). The study revealed that co-digestion shows better performance compared to the mono-digestion of both substrates. Vn:WH mixing ratio 1:1 with inoculum to substrate ratio (ISR) of 0.38 g VSᵢₙₒcᵤₗᵤₘ/g VSₛᵤbₛₜᵣₐₜₑ is the most favorable ratio, achieving sCOD reduction efficiency and cumulative biogas production of 71.6% and 1229 mL, respectively. Model selection through AIC revealed that ratio 1:1 was best fitted to the logistic function kinetic model (R² = 0.9897) with Yₘ and K values of 1232 mL and 31 mL/day, respectively.

Atrazine (ATZ), a widely used herbicide, had received a significant amount of attention due to its widespread detection in aquatic environments as well as its potential risks to human health. UV/persulfate (PS) process is an emerging technology for degrading organic pollutants in water. Thus, the degradation of ATZ by a UV/PS process was investigated in this study. The results showed that the removal rate of ATZ was 98.4% with a PS dosage of 2 mg/L and an initial ATZ concentration of 0.1 mg/L. In addition, a relatively high degradation efficiency was obtained under pH = 7. However, the addition of humic acid (HA) reduced the removal rate of ATZ. Hydroxyl radicals (•OH) and sulfate radicals (•SO₄⁻) respectively contributed to 21.7% and 29% of the ATZ degradation. The ATZ degradation pathway was proposed, and the main reactions of ATZ in this UV/PS process included dechlorination, demethylation, and deethylation. Moreover, the toxicity of ATZ and its degradation products was assessed using the Toxicity Estimation Software Tool (TEST), and the results showed that the toxicity of the ATZ solution was reduced after the UV/PS process. These results indicate that UV/PS shows good promise as a remediation technique for the treatment of persistent herbicides such as ATZ in contaminated water.

Air pollution is a critical risk factor for the prevalence of COVID-19. However, few studies have focused on whether air pollution affects the efficacy of the SARS-CoV-2 vaccine. To better guide the knowledge surrounding this vaccination, we conducted a cross-section study to identify the relationships between air pollutant exposure and plasma neutralizing antibody (NAb) titers of an inactivated SARS-CoV-2 vaccine (Vero cell, CoronaVac, SINOVΛC, China). We recruited 239 healthcare workers aged 21–50 years who worked at Suining Central Hospital. Of these, 207 were included in this study, depending on vaccination date. The data regarding air pollutants were collected to calculate individual daily exposure dose (DED). The geometric mean of all six pollutant DEDs was applied to estimate the combined toxic effects (DEDcₒₘₚₗₑₓ). Then, the participants were divided into two groups based on the mean value of DEDcₒₘₚₗₑₓ. The median plasma NAb titer was 12.81 AU/mL, with 85.99% vaccine efficacy in healthcare workers against SARS-CoV-2. In exposure group, observations included lower plasma NAb titers (median: 11.13 AU/mL vs. 14.56 AU/mL), more peripheral counts of white blood cells and monocytes (mean: 6.71 × 10⁹/L vs. 6.29 × 10⁹/L and 0.49 × 10⁹/L vs. 0.40 × 10⁹/L, respectively), and a higher peripheral monocyte ratio (7.38% vs. 6.50%) as compared to the reference group. In addition, elevated air pollutant DEDs were associated with decreased plasma NAb titers. To our knowledge, this study is the first to report the relationship between air pollutant exposure and plasma NAb titers of the SARS-CoV-2 vaccine. This suggests that long-term exposure to air pollutants may inhibit plasma NAb expression by inducing chronic inflammation. Therefore, to achieve early herd immunity and hopefully curb the COVID-19 epidemic, vaccinations should be administered promptly to those eligible, and environmental factors should be considered as well.

China has been the world’s largest emitter of carbon dioxide since 2006. To achieve the goal of carbon neutrality by 2060, social scientists must become involved in China’s deep decarbonization process. However, Chinese social scientists have given little attention to climate change in their bibliometric research. Based on the Chinese Social Sciences Citation Index journal catalog of the four essential social sciences, namely, management, economics, politics, and sociology, we used the China National Knowledge Infrastructure database to quantify the extent to which Chinese social scientists are concerned about climate change. The results showed that from 1978 to 2020, 1179 articles on climate change were published in management, economics, politics, and sociology journals, which represented only 26.8% of the 4397 articles published on pollution in the same journals. Politics journals published the most articles (38.76%), while sociology journals published the fewest (2.37%). Thus, Chinese social scientists rarely considered climate change, mainly because this topic remains controversial in some fields and because of the influence of international politics in addition to the promotion and incentive mechanisms for researchers. We analyzed the keywords and evolution of climate change research in the four social sciences and our results show that social scientists should give greater emphasis to climate change in their research.

Non-small cell lung cancer (NSCLC) is reported to have a high incidence rate and is one of the most prevalent types of cancer contributing towards 85% of all incidences of lung cancer. Berberine is an isoquinoline alkaloid which offers a broad range of therapeutical and pharmacological actions against cancer. However, extremely low water solubility and poor oral bioavailability have largely restricted its therapeutic applications. To overcome these limitations, we formulated berberine-loaded liquid crystalline nanoparticles (LCNs) and investigated their in vitro antiproliferative and antimigratory activity in human lung epithelial cancer cell line (A549). 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), trypan blue staining, and colony forming assays were used to evaluate the anti-proliferative activity, while scratch wound healing assay and a modified Boyden chamber assay were carried out to determine the anti-migratory activity. We also investigated major proteins associated with lung cancer progression. The developed nanoparticles were found to have an average particle size of 181.3 nm with spherical shape, high entrapment efficiency (75.35%) and have shown sustained release behaviour. The most remarkable findings reported with berberine-loaded LCNs were significant suppression of proliferation, inhibition of colony formation, inhibition of invasion or migration via epithelial mesenchymal transition, and proliferation related proteins associated with cancer progression. Our findings suggest that anti-cancer compounds with the problem of poor solubility and bioavailability can be overcome by formulating them into nanotechnology-based delivery systems for better efficacy. Further in-depth investigations into anti-cancer mechanistic research will expand and strengthen the current findings of berberine-LCNs as a potential NSCLC treatment option.

In this study, the performance of shortcut nitrification–denitrification (SCND) at different TC and SD stress conditions (0 μg/L, 1–97 days; 100 μg/L, 98–138 days; 500 μg/L, 139–175 days) was investigated. Higher level antibiotic stress (500 μg/L) led to the serious deterioration of nitrogen removal, and denitrification was more sensitive to antibiotic stress than nitrification. The dynamics of antibiotic resistance genes (ARGs) and microbial community were revealed by quantitative real-time PCR and 16S rDNA high-throughput sequencing, respectively. Tet-genes (tetA, tetQ, tetW), sul-genes (sulI, sulII), and mobile genetic element (intI1) in activated sludge increased by 1.2 ~ 2.5 logs with long-term exposure of antibiotic stress, and sulI, tetA, tetQ, and tetW were significantly positively correlated with intI1. Long-term antibiotics stress caused the decrease of most denitrifiers, and five genera were identified as the potential host of ARGs. The key impact factors of SCND drove the dynamics of ARGs and microbial community. Except for sulII gene, DO and FA were significantly positively correlated with ARGs, while FNA, NAR, and NO₂⁻-N showed opposite effects to ARGs. Overall, maintaining relative lower DO, higher FNA, NAR, and NO₂⁻-N conditions are not only benefit to the stable operation of SCND, but may also conducive to the control of ARG dissemination. This study provides theoretical basis on the control of ARGs in the SCND process.