Microcystins (MCs) produced by cyanobacteria are potent toxins to humans that cannot be ignored. However, the toxicity of MCs to humans remains largely unknown. The study explored the role of MCs in the development of hematological parameters through human observations and a chronic mouse model to explore related mechanisms. The adjusted odds ratio of MC-LR to the risk of anemia was 4.954 (95 % CI, 2.423–10.131) in a case-control study in Nanjing. An inverse correlation between serum MC-LR and hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), and red blood cell count (RBC) was observed. MC-LR in the serum of the population was an independent risk factor for microcytic anemia. Animal experiments demonstrated that MC-LR resulted in microcytic anemia, which is associated with inflammation, dysregulation of iron homeostasis, and erythropoiesis. We first identified the possible signaling pathway of MC-LR-induced anemia that MC-LR significantly upregulated the levels of hepcidin via EPO/EPOR signaling pathway and the decreased levels of Twsg1 and Gdf15, thereby resulting in the decreased levels of Hbb and Fpn, and the increased expression of Fth1, and Tf in a chronic mouse model. Our study first identified that prolonged environmental exposure to MCs probably contribute to the occurrence of microcytic anemia in humans, which provides new insights into the toxicity of MCs for public health.

Recent studies suggested that long-term exposure to fine particulate matter (PM₂.₅) was related to a higher risk of dementia incidence or hospitalizations in western populations, but the evidence is limited in Asian cities. Here we explored the link between long-term PM₂.₅ exposure and dementia incidence in the Hong Kong population and whether it varied by population sub-group. We utilized a Hong Kong Chinese cohort of 66,820 people aged ≥65 years who were voluntarily enrolled during 1998–2001 and were followed up to 2011. Prevalent dementia cases were excluded based on the face-to-face interview at baseline. We ascertained the first occurrence of hospitalization for all-cause dementia and major subtypes during the follow-up period. We assessed PM₂.₅ concentrations using a satellite data-based model with a 1 × 1 km² resolution on the residential address. Cox proportional hazards models were adopted to estimate associations of annual mean PM₂.₅ exposure with dementia incidence, adjusting for potential confounders. We identified 1183 incident cases of all-cause dementia during the follow-up period, of which 655 (55.4%) were cases of Alzheimer’s disease, and 334 (28.2%) were those of vascular dementia. We found a positive association between annual mean PM₂.₅ exposure and all-cause dementia incidence in the fully adjusted model. The estimated hazard ratio was 1.06 (95% confidence interval (CI): 1.00, 1.13) per every 3.8 μg/m³ increase in annual mean PM₂.₅ exposure. And the estimated HRs for Alzheimer’s disease and vascular dementia were 1.03 (95% CI: 0.94, 1.12) and 1.09 (95% CI: 0.98, 1.22), respectively. We did not find effect modifications by age, sex, BMI, hypertension, diabetes, or heart disease on the associations. Results suggest that long-term exposure to PM₂.₅ is associated with a higher risk of dementia incidence in the Asian population.

Since 2004, there has been a marked diversification in the methods used to determine aquatic microplastic (MP) concentrations. Despite calls for a unified approach to MP sampling, the proliferation of new methods has accelerated in recent years. Both minor method adaptations and entirely novel approaches have been introduced to overcome barriers to reliable MP sampling, extraction and quantification, resulting in a variety of complimentary but also competing approaches. However, there is little clarity regarding the extent to which new methods are acknowledged and adopted, or of the apparent drivers of, as well as barriers to, said adoption. To explore these issues, the rate of method diversification was examined in a systematic review. The rate and degree of diversification were determined by scoring each method by its “degree of novelty”: highly novel methods, secondary adaptations of existing methods and smaller, tertiary adaptations of existing methods. This analysis revealed that the rate of method diversification has been greatest since 2011. Our results indicate limited use of these novel methods and adaptations in the subsequent literature, with many researchers falling back on methods that are well established in the existing literature. Importantly, there is little consistency in the units used when reporting MP concentrations. However, these differences are seldom driven by method selection and are rather the result of discrepancies between researchers. Thus, in understanding the requirements of comparability and consistent reporting for monitoring purposes, we can apply a diverse approach to sampling whilst maintaining the applicability and usefulness of the resulting data.

Pesticides are widely used to alleviate pest pressure in agricultural systems, and atrazine is a typical diffuse pollutant and serves a sensitivity index for environmental characteristics. Based on the physicochemical properties of parent substances, degradation products of pesticides may pose a greater threat to aquatic ecosystems than pesticides. Atrazine and three primary degradation products (deethylatrazine (DEA), deisopropylatrazine (DIA) and didealkylatrazine (DDA)) were investigated in a semienclosed bay of the western Pacific Ocean. Seasonal surface water and suspended particulate sediment (SPS) samples were collected from the estuary and bay in January, April, and August 2019. The level of pesticide contamination was lower in the bay than in the estuary, and the pesticide concentration in the dissolved phase was higher than that in the adsorbed phase. The average concentrations of atrazine and the three degradation products in the three seasons ranged from 2.42 to 328.46 ng/L in water and from 0.07 to 12.75 ng/L in SPS. The proportion of atrazine among the four detected pollutants decreased from 0.7 to 0.1 in surface water and from 0.3 to 0.1 in SPS over the seasons. As the main degradation products, the concentration proportions of DDA and DEA reached as high as 0.6 in August. The ratio of DEA to atrazine (DEA/ATR) increased from January to August, which indicated the progressive degradation process in the bay. Single-factor analysis of variance and principal component analysis indicated that atrazine degradation was sensitive to temperature, dissolved oxygen, and salinity. These three factors accounted for almost 70% of the seasonal variance in atrazine without a quantification assessment of photolysis or bacteria. The spatial distributions of DEA in the three seasons demonstrated that wind and currents also played important roles in pollutant redistribution. The seasonal temporal and spatial correlations between water and SPS demonstrated the degradation patterns of atrazine in marine conditions, supporting the need for future detailed toxicity studies.

We aimed to update the evidence-base of long-term noise exposures from road, rail, and aircraft traffic on both non-accidental and cardiovascular mortality.A systematic review and meta-analysis were conducted following PRISMA guidelines. The literature was searched using PubMed, Scopus, Web of Science, and EMBASE for the period between January 01, 2000 and October 05, 2020. 13 studies were selected for final review. The risk of bias and overall quality of evidence was evaluated using a pre-defined list of criteria. Risk estimates from each study were converted into per 10 dB higher of Ldₑₙ for each traffic source. Inverse-Variance heterogeneity (I-Vhet) meta-analysis was used to pool these individual risk estimates, along with assessment of heterogeneity and publication bias. Sensitivity analyses include using random-effect model and leave-one-out meta-analysis. Subgroup analyses by study design and noise exposure assessment were conducted to explore potential sources of heterogeneity.For road traffic, the pooled relative risk (RR) per 10 dB higher Ldₑₙ for mortality from non-accidental causes was 1.01 (95% CI: 0.98, 1.05) (5 studies, I² = 78%), CVD was 1.01 (95% CI: 0.98, 1.05) (5 studies, I² = 41%), ischemic heart disease (IHD) was 1.03 (95% CI: 0.99, 1.08) (7 studies, I² = 46%), and stroke was 1.05 (95% CI: 0.97, 1.14) (5 studies, I² = 62%). The overall quality of evidence for most meta-analyses was rated as very low to low, except for CVD or IHD mortality, for which the quality of evidence was rated as moderate. A possible threshold of 53 dB was visually suggested for CVD-related mortality from road traffic noise in the trend analysis. For aircraft noise, pooled estimates were based on fewer studies and varied by mortality outcomes.Evidence of long-term exposure to traffic noise on mortality remains weak except the association between road traffic noise and IHD mortality. High-quality longitudinal studies are required to better characterise mortality effects of traffic noise.

Aquatic pollution from emerging organic contaminants (EOCs) is of key environmental importance in India and globally, particularly due to concerns of antimicrobial resistance, ecotoxicity and drinking water supply vulnerability. Here, using a broad screening approach, we characterize the composition and distribution of EOCs in groundwater in the Gangetic Plain around Patna (Bihar), as an exemplar of a rapidly developing urban area in northern India. A total of 73 EOCs were detected in 51 samples, typically at ng.L⁻¹ to low μg.L⁻¹ concentrations, relating to medical and veterinary, agrochemical, industrial and lifestyle usage. Concentrations were often dominated by the lifestyle chemical and artificial sweetener sucralose. Seventeen identified EOCs are flagged as priority compounds by the European Commission, World Health Organisation and/or World Organisation for Animal Health: namely, herbicides diuron and atrazine; insecticides imidacloprid, thiamethoxam, clothianidin and acetamiprid; the surfactant perfluorooctane sulfonate (and related perfluorobutane sulfonate, perfluorohexane sulfonate, perfluorooctanoic acid and perfluoropentane sulfonate); and medical/veterinary compounds sulfamethoxazole, sulfanilamide, dapson, sulfathiazole, sulfamethazine and diclofenac. The spatial distribution of EOCs varies widely, with concentrations declining with depth, consistent with a strong dominant vertical flow control. Groundwater EOC concentrations in Patna were found to peak within ∼10 km distance from the River Ganges, indicating mainly urban inputs with some local pollution hotspots. A heterogeneous relationship between EOCs and population density likely reflects confounding factors including varying input types and controls (e.g. spatial, temporal), wastewater treatment infrastructure and groundwater abstraction. Strong seasonal agreement in EOC concentrations was observed. Co-existence of limited transformation products with associated parent compounds indicate active microbial degradation processes. This study characterizes key controls on the distribution of groundwater EOCs across the urban to rural transition near Patna, as a rapidly developing Indian city, and contributes to the wider understanding of the vulnerability of shallow groundwater to surface-derived contamination in similar environments.

The presence of phenols, such as nonylphenol (NP), bisphenol (BPA), and octylphenol (OP), in the environment have been receiving increased attention due to their potential risks to human health and environment. The use of reclaimed water for irrigation may be one of the sources of these phenols in the agricultural system. A field experiment was conducted to assess the effects of reclaimed water irrigation on phenol contamination of agricultural topsoil and products in the North China Plain between 2015 and 2016. Three irrigation treatments were applied to all crops: reclaimed water irrigation, groundwater irrigation and alternative irrigation with reclaimed water and groundwater (1:1, v/v). The results showed that the concentrations of NP, BPA, and OP in the topsoil were 0.02–0.54, 0.004–0.06, and ND–9.9 × 10⁻³ mg/kg, respectively; the corresponding values in agricultural products were 0.007–0.70, 0.004–0.24, and ND–1.08 mg/kg, respectively. The concentration of NP in the topsoil and agricultural products and that of BPA in the agricultural products were all less than the recommended limits. The yields of wheat, maize, vegetables were 4.35–7.08, 1.03–6.46, and 10.9–67.0 t/ha, respectively. The bioaccumulation factors (BCFs) of OP, NP, and BPA for cereals were 0.7–4.77, 0.16–4.59, and 1.3–23.9, respectively; the corresponding values in vegetables were 0.0–4.53 (except cucumber and eggplant), 0.38–12.6, and 0.57–24.3, respectively. No significant differences in phenol concentrations, BCFs, or yields of wheat and vegetables were observed among the three irrigation treatments. In conclusion, compared with groundwater irrigation, reclaimed water irrigation in this experiment did not significantly affect phenol concentrations in the topsoil and agricultural products as well as BCFs and yields of wheat and vegetables. However, because the quality of reclaimed water may vary across collected areas, additional experiments are warranted to analyze the effects of reclaimed water irrigation on the risk of phenol contamination.

In order to study the co-existing environment of pests and economic animals, the toxicity of 15 insecticides to Plutella xylostella, Monopterus albus, and Paramisgurnus dabryanus was tested. Combined with the recommended maximum doses in the field and bioassay, the results showed that for the three insecticides that were of relatively low toxicity to M. albus and P. dabryanus, spinetoram showed the best control effect on P. xylostella, followed by chlorfenapyr and chlorantraniliprole. However, P. xylostella showed a relatively high resistance to chlorfenapyr. Therefore, the best insecticide suitable for the fields with the cauliflower-finless eel or cauliflower-loach planting and rearing combination was spinetoram, followed by chlorantraniliprole and chlorfenapyr. Other insecticides such as emamectin benzoate, Bacillus thuringiensis (Bt), matrine, and so on were effective against the diamondback moth, but they were not suitable for use because of their high toxicity to the finless eel and loach.

Knowledge of the concentration of the bioavailable forms of mercury in the soil is necessary, especially, if these soils contain above-limit total mercury concentrations. The bioavailability of mercury in soil samples collected from the vicinity of abandoned cinnabar mines was evaluated using diffusive gradients in the thin films technique (DGT) and mercury phytoaccumulation by vegetables (lettuce, spinach, radish, beetroot, carrot, and green peas). Mercury was accumulated primarily in roots of vegetables. The phytoaccumulation of mercury into edible plant parts was site-specific as well as vegetable species-specific. The mercury concentration in edible parts decreased in the order: spinach leaf ≥ lettuce leaf ≥ carrot storage root ≥ beetroot storage root > radish storage root > pea legume. The translocation index as well as the target hazard quotient indicate the possible usability of soils from the vicinity of abandoned cinnabar mines for planting pod vegetables (peas). A strong positive correlation (r = 0.75 to 0.92, n > 30, p < 0.05) was observed between mercury concentration in secondary roots, the storage roots, leaves of vegetables and the flux of mercury from soil to the DGT units, and the effective concentration of mercury in soil solutions.

Rising of temperature in conjunction with acidification due to the anthropogenic climates has tremendously affected all aquatic life. Small changes in the surrounding environment could lead to physiological constraint in the individual. Therefore, this study was designed to investigate the effects of warm water temperature (32 °C) and low pH (pH 6) on physiological responses and growth of hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂) juveniles for 25 days. Growth performance was significantly affected under warm water temperature and low-pH conditions. Surprisingly, the positive effect on growth was observed under the interactive effects of warm water and low pH exposure. Hybrid grouper exposed to the interactive stressor of warm temperature and low pH exhibited higher living cost, where HSI content was greatly depleted to about 2.3-folds than in normal circumstances. Overall, challenge to warm temperature and low pH induced protein mobilization as an energy source followed by glycogen and lipid to support basal metabolic needs.