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Environmentally relevant concentrations of arsenite induces developmental toxicity and oxidative responses in the early life stage of zebrafish
2019
Sun, Hong-Jie | Zhang, Jing-Ying | Wang, Qiang | Zhu, Engao | Chen, Wenrong | Lin, Hongjun | Chen, Jianrong | Hong, Huachang
Arsenic (As) present in water is a nonignorable environmental issue, even at low concentrations (≤150 μg L⁻¹). To evaluate the toxic effect of low concentrations of As, zebrafish at early life stage were exposed to 0, 25, 50, 75, or 150 μg L⁻¹ AsIII for 120 h. Our results indicated that low concentration of AsIII decreased zebrafish larvae’s survival rate to 85%, 89% and 86% at 50, 75 and 150 μg L⁻¹. Furthermore, low concentrations of AsIII exposure caused oxidative stress (elevated superoxide dismutase (SOD) activity and influenced the mRNA transcriptional levels of Cu/ZnSOD and MnSOD) and damage (increased malondialdehyde levels). Meanwhile, zebrafish larvae regulated the mRNA transcription of metallothionein and heat shock protein 70 to alleviate toxicity caused by AsIII. These results revealed lower concentrations (≤150 μg L⁻¹) of AsIII had a detriment effect on the survival of fish at early life stage, moreover, oxidative stress caused by AsIII posed potential risk for the zebrafish. This study provides novel insight into low concentration AsIII-induced toxicity in zebrafish.
Show more [+] Less [-]Response of aerosol chemistry to clean air action in Beijing, China: Insights from two-year ACSM measurements and model simulations
2019
Zhou, Wei | Gao, Meng | He, Yao | Wang, Qingqing | Xie, Conghui | Xu, Weiqi | Zhao, Jian | Du, Wei | Qiu, Yanmei | Lei, Lu | Fu, Pingqing | Wang, Zifa | Worsnop, Douglas R. | Zhang, Qiang | Sun, Yele
Despite substantial mitigation of particulate matter (PM) pollution during the past decade in Beijing, the response of aerosol chemistry to clean air action and meteorology remains less understood. Here we characterized the changes in aerosol composition as responses to emission reductions by using two-year long-term measurements in 2011/2012 and 2017/2018, and WRF-Chem model. Our results showed substantial decreases for all aerosol species except nitrate from 2011/2012 to 2017/2018. Chloride exhibited the largest decrease by 65–89% followed by organics (37–70%), mainly due to reductions in coal combustion emissions in winter and agriculture burning in June. Primary and secondary organic aerosol (SOA) showed comparable decreases by 61–70% in fall and winter, and 34–63% in spring and summer, suggesting that reductions in primary emissions might also suppress SOA formation. The changes in nitrate were negligible and even showed increases due to less reductions in NOₓ emissions and increased formation potential from N₂O₅ heterogeneous reactions. As a result, nitrate exceeded sulfate and became the major secondary inorganic aerosol species in PM with the contribution increasing from 14–21% to 22–32%. Further analysis indicated that the reductions in aerosol species from 2011/2012 to 2017/2018 were mainly caused by the decreases of severely polluted events (PM₁ > 100 μg m⁻³). WRF-Chem simulations suggested that the decreases in OA and sulfate in fall and winter were mainly resulted from emission reductions (27–36% and 25–43%) and favorable meteorology (4–10% and 19–30%), while they were dominantly contributed by emission changes in spring and summer. Comparatively, the changes in nitrate were mainly associated with meteorological variations while the contributions of emissions changes were relatively small. Our results highlight different chemical responses of aerosol species to emission changes and meteorology, suggesting that future mitigation of air pollution in China needs species-targeted control policy.
Show more [+] Less [-]Effects of triphenyl phosphate exposure during fetal development on obesity and metabolic dysfunctions in adult mice: Impaired lipid metabolism and intestinal dysbiosis
2019
Wang, Dezhen | Yan, Sen | Yan, Jin | Teng, Miaomiao | Meng, Zhiyuan | Li, Ruisheng | Zhou, Zhiqiang | Zhu, Wentao
Previous in vitro studies have implied that triphenyl phosphate (TPHP) may act as an obesogen. However, its specific contributions to the progression of obesity and related metabolic diseases are still unclear in vivo in mice. In this study, we evaluated the effects of in utero and lactational exposure to three doses of TPHP (10, 100, and 1000 μg/kg BW) on obesity and metabolic dysfunctions in adult male mice fed a low-fat diet (LFD) or high-fat diet (HFD), by examining body weight, liver weight, histopathology, blood biochemistry, gene expression, and gut microbiota compositions and metabolic functions. Results showed that TPHP exposure led to increased body weight, liver weight, fat mass, hepatic steatosis, impaired glucose homeostasis, and insulin resistance, and mRNA levels of genes involved in lipid metabolism, especially lipogenesis and lipid accumulation, were significantly altered by TPHP treatment. Gas chromatography-mass spectrometry (GC-MS) analysis further supported the changes in fatty acid composition. Intestinal flora measurements by 16S rRNA gene sequencing and ¹H NMR based fecal metabolomics indicated that TPHP treatment modulated gut microbiome composition and influenced host-gut co-metabolism, especially for bile acids and short chain fatty acids (SCFAs). These results suggest that fetal exposure to TPHP can promote the development of obesity and metabolic dysfunctions in adult mice.
Show more [+] Less [-]Aircraft soot from conventional fuels and biofuels during ground idle and climb-out conditions: Electron microscopy and X-ray micro-spectroscopy
2019
Liati, A. | Schreiber, D. | Alpert, P.A. | Liao, Y. | Brem, B.T. | Corral Arroyo, P. | Hu, J. | Jonsdottir, H.R. | Ammann, M. | Dimopoulos Eggenschwiler, P.
Aircraft soot has a significant impact on global and local air pollution and is of particular concern for the population working at airports and living nearby. The morphology and chemistry of soot are related to its reactivity and depend mainly on engine operating conditions and fuel-type. We investigated the morphology (by transmission electron microscopy) and chemistry (by X-ray micro-spectroscopy) of soot from the exhaust of a CFM 56-7B26 turbofan engine, currently the most common engine in aviation fleet, operated in the test cell of SR Technics, Zurich airport. Standard kerosene (Jet A-1) and a biofuel blend (Jet A-1 with 32% HEFA) were used at ground idle and climb-out engine thrust, as these conditions highly influence air quality at airport areas. The results indicate that soot reactivity decreases from ground idle to climb-out conditions for both fuel types. Nearly one third of the primary soot particles generated by the blended fuel at climb-out engine thrust bear an outer amorphous shell implying higher reactivity. This characteristic referring to soot reactivity needs to be taken into account when evaluating the advantage of HEFA blending at high engine thrust. The soot type that is most prone to react with its surrounding is generated by Jet A-1 fuel at ground idle. Biofuel blending slightly lowers soot reactivity at ground idle but does the opposite at climb-out conditions. As far as soot reactivity is concerned, biofuels can prove beneficial for airports where ground idle is a common situation; the benefit of biofuels for climb-out conditions is uncertain.
Show more [+] Less [-]Effect of percolation and chemical form on Pb bioavailability and toxicity to the soil invertebrate Enchytraeus crypticus in freshly spiked and aged soils
2019
Zhang, Lulu | Van Gestel, Cornelis A.M.
In standard terrestrial ecotoxicological tests, soils usually are spiked with highly soluble metal salts leading to overestimation of bioavailability and introducing counterions that may contribute to toxicity. Leaching is suggested as an efficient method to avoid the effects of the associated counterions. The present study aimed at investigating the effects of leaching on the bioavailability and toxicity of Pb(NO₃)₂ and PbO to the potworm Enchytraeus crypticus in LUFA 2.2 soil freshly spiked or after 18 months ageing. Percolation decreased porewater Pb concentrations as well as the toxicity of both Pb forms. The influence of percolation differed between the two Pb forms and between freshly spiked and aged soils. Percolation slightly increased LC50s based on total soil Pb concentrations for Pb(NO₃)₂, but not for PbO, and only affected Pb toxicity to enchytraeid reproduction in freshly spiked soils. The differences in Pb uptake in E. crypticus and toxicity between the two Pb forms as well as between different treatments could be minimized by relating them to 0.01 M CaCl₂-extractable concentrations. In addition, body Pb concentrations could well explain enchytraeid survival across all soils and treatments, indicating its suitability as a good proxy for Pb toxicity in soil.
Show more [+] Less [-]Carbonaceous aerosol characteristics on the Third Pole: A primary study based on the Atmospheric Pollution and Cryospheric Change (APCC) network
2019
Chen, Pengfei | Kang, Shichang | Li, Yizhong | Zhang, Qianggong | Guo, Junming | Tripathee, Lekhendra | Zhang, Yulan | Li, Gang | Gul, Chaman | Cong, Zhiyuan | Wan, Xin | Niu, Hewen | Panday, Arnico K. | Rupakheti, Maheswar | Ji, Zhenming
Carbonaceous aerosols (CAs) scatter and absorb incident solar radiation in the atmosphere, thereby influencing the regional climate and hydrological cycle, particularly in the Third Pole (TP). Here, we present the characteristics of CAs at 19 observation stations from the Atmospheric Pollution and Cryospheric Change network to obtain a deep understanding of pollutant status in the TP. The organic carbon (OC) and elemental carbon (EC) concentrations decreased noticeably inwards from outside to inland of the TP, consistent with their emission load and also affected by transport process and meteorological condition. Urban areas, such as Kathmandu, Karachi, and Mardan, exhibited extremely high OC and EC concentrations, with low and high values occurring in the monsoon and non-monsoon seasons, respectively. However, remote regions inland the TP (e.g., Nam Co and Ngari) demonstrated much lower OC and EC concentrations. Different seasonal variations were observed between the southern and northern parts of the TP, suggesting differences in the patterns of pollutant sources and in distance from the sources between the two regions. In addition to the influence of long-range transported pollutants from the Indo-Gangetic Plain (IGP), the TP was affected by local emissions (e.g., biomass burning). The OC/EC ratio also suggested that biomass burning was prevalent in the center TP, whereas the marginal sites (e.g., Jomsom, Dhunche, and Laohugou) were affected by fossil fuel combustion from the up-wind regions. The mass absorption cross-section of EC (MACEC) at 632 nm ranged from 6.56 to 14.7 m² g⁻¹, with an increasing trend from outside to inland of the TP. Urban areas had low MACEC values because such regions were mainly affected by local fresh emissions. In addition, large amount of brown carbon can decrease the MACEC values in cities of South Asia. Remote sites had high MACEC values because of the coating enhancement of aerosols.Influenced by emission, transport process, and weather condition, the CA concentrations and MACEC presented decreasing and increasing trends, respectively, from outside to inland of the TP.
Show more [+] Less [-]Sublethal insecticide exposure of an herbivore alters the response of its predator
2019
Müller, Thorben | Gesing, Matthias Alexander | Segeler, Markus | Muller, Caroline
Sublethal insecticide exposure poses risks for many non-target organisms and is a challenge for successful implementation of integrated pest management (IPM) programs. Next to detrimental effects of short-term insecticide exposure on fitness-related traits of organisms, also properties such as chemical signaling traits can be altered, which mediate intra- and interspecific communication. We investigated the effects of different durations of larval sublethal exposure to the pyrethroid lambda-cyhalothrin on performance traits of larvae and adults of the herbivorous mustard leaf beetle, Phaedon cochleariae. Moreover, by applying a direct contact and olfactometer bioassays, we determined the reaction of a generalist predator, the ant Myrmica rubra, towards insecticide-exposed and unexposed herbivore larvae and their secretions. Already short-term sublethal insecticide exposure of a few days caused a prolonged larval development and a reduced adult body mass of males. These effects may result from an insecticide-induced reduction in energy reserves. Furthermore, ants responded more frequently to insecticide-exposed than to unexposed larvae of P. cochleariae and their secretions. This increased responsiveness of ants towards insecticide-exposed larvae may be due to an insecticide-induced change in synthesis of chrysomelidial and epichrysomelidial, the dominant compounds of the larval secretion, which act defensive against various generalist predators. In conclusion, the results highlight that short-term insecticide exposure can impair the fitness of an herbivorous species due to both direct toxic effects and an increased responsiveness of predators. Consequently, exposure of single non-target species can have consequences for ecological communities in both natural habitats and IPM programs.
Show more [+] Less [-]Source specific sound mapping: Spatial, temporal and spectral distribution of sound in the Dutch North Sea
2019
Sertlek, Hüseyin Özkan | Slabbekoorn, Hans | Cate, Carel ten | Ainslie, Michael A.
Effective measures for protecting and preserving the marine environment require an understanding of the potential impact of anthropogenic sound on marine life. A crucial component is a proper assessment of the anthropogenic soundscape: which sounds are present where, when and how strong? We provide an extensive case study modelling the spatial, temporal and spectral distribution of sound radiated by several anthropogenic sources (ships, seismic airguns, explosives) and a naturally occurring one (wind) in the Dutch North Sea. We present the results as a series of sound maps covering the whole of the Dutch North Sea, showing the spatial and temporal distribution of the energy from these sources. Averaged over a two year period, shipping is responsible for the largest amount of acoustic energy (∼1800 J), followed by seismic surveys (∼300 J), explosions (∼20 J) and wind (∼20 J) in the frequency band between 100 Hz and 100 kHz. Our study shows that anthropogenic sources are responsible for 100 times more acoustic energy (averaged over 2 years) in the Dutch North Sea than naturally occurring sound from wind. The potential impact of these sounds on aquatic animals depends not only on these temporally averaged and spatially integrated broadband energies, but also on the source-specific spatial, spectral and temporal variation. Shipping is dominant in the southern part and along the coast in the north, throughout the years and across the spectrum. Seismic surveys are relatively local and spatially and temporally dependent on exploration activities in any particular year, and spectrally shifted to low frequencies relative to the other sources. Explosions in the southern part contribute wide-extent high energy bursts across the spectrum. Relating modelled sound fields to the temporal and spatial distribution of animal species may provide a powerful tool for understanding the potential impact of anthropogenic sound on marine life.
Show more [+] Less [-]The association between prenatal cadmium exposure and birth weight: A systematic review and meta-analysis of available evidence
2019
Huang, Shouhe | Kuang, Jie | Zhou, Fankun | Jia, Qiyue | Lu, Qi | Feng, Zhang | Yang, Wei | Fan, Guangqin
We conducted a meta-analysis to evaluate the association between prenatal cadmium (Cd) exposure and birth weight. PubMed, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases were searched for studies published before March 2019. We used a model-based method, standardizing effect size from linear regression models to include a maximum number of studies during our quantitative evaluations. As a result, 11 articles from the general population, containing 10 birth cohorts and one cross-sectional study, were included. Our meta-analysis demonstrated that a 50% increase of maternal urine Cd (UCd) would be associated with a 6.15 g decrease in neonatal birth weight (β = −6.15 g, 95% CI: −10.81, −1.49) as well as a 50% increase of maternal blood Cd (BCd) would be associated with an 11.57 g decrease (β = −11.57 g; 95% CI: −18.85, −4.30). Stratified analysis of UCd data indicated that the results of female newborns were statistically significant (β = −8.92 g, 95% CI: −17.51, −0.34), as was the first trimester (β = −11.34 g, 95% CI: −19.54, −3.14). Furthermore, increased UCd levels were associated with a higher rate of low birth weight (LBW) risk (OR = 1.12, 95% CI: 1.03, 1.22). This meta-analysis demonstrated that elevated maternal Cd levels are associated with decreased birth weight and higher LBW risk.
Show more [+] Less [-]Influence of macromolecules on aggregation kinetics of diesel soot nanoparticles in aquatic environments
2019
Chen, Chengyu | Wei, Jingyue | Li, Jing | Duan, Zhihui | Huang, Weilin
Soot nanoparticles (SNPs) produced from incomplete combustion have strong impacts on aquatic environments as they eventually reach surface water, where their environmental fate and transport are largely controlled by aggregation. This study investigated the aggregation kinetics of SNPs in the presence of macromolecules including fulvic acid (FA), humic acid (HA), alginate polysaccharide, and bovine serum albumin (BSA, protein) under various environmentally relevant solution conditions. Our results showed that increasing salt concentrations induced SNP aggregation by suppressing electrostatic repulsion and that CaCl2 exhibited stronger effect than NaCl in charge neutralization, which is in agreement with the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. The aggregation rates of SNPs were variously reduced by macromolecules, and such stabilization effect was the greatest by BSA, followed by HA, alginate, and FA. Steric repulsion resulting from macromolecules adsorbed on SNP surfaces was mainly responsible for enhancing SNP stability. Such steric repulsion appeared to be affected by macromolecular structure, as BSA having a more compact globular structure on SNP surfaces imparted long-range steric repulsive forces and retarded the SNP aggregation rate by 10–100 times. In addition, alginate was shown to enhance SNP aggregation by ∼10 times at high CaCl2 concentrations due to alginate gel formation via calcium bridging. The results may bear strong significance for the fate and transport of SNPs in both natural and controlled environmental systems.
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