Indoor air pollution is associated with numerous adverse health outcomes. Air purifiers are widely used to reduce indoor air pollutants. Ionization air purifiers are becoming increasingly popular for their low power consumption and noise, yet its health effects remain unclear. This randomized, double-blind crossover study is conducted to explore the cardiorespiratory effects of ionization air purification among 44 children in Beijing. Real or sham purification was performed in classrooms for 5 weekdays. Size-fractionated particulate matter (PM), black carbon (BC), ozone (O₃), and negative air ions (NAI) were monitored, and cardiorespiratory functions were measured. Mixed-effect models were used to establish associations between exposures and health parameters. Real purification significantly decreased PM and BC, e.g. PM₀.₅, PM₂.₅, PM₁₀ and BC were decreased by 48%, 44%, 34% and 50%, respectively. O₃ levels were unchanged, while NAI was increased from 12 cm⁻³ to 12,997 cm⁻³. Real purification was associated with a 4.4% increase in forced exhaled volume in 1 s (FEV₁) and a 14.7% decrease in fractional exhaled nitrogen oxide (FeNO). However, heart rate variability (HRV) was altered negatively. Interaction effects of NAI and PM were observed only on HRV, and alterations in HRV were greater with high NAI. Ionization air purifier could bring substantial respiratory benefits, however, the potential negative effects on HRV need further investigation.

This study aimed to determine if there is a co-elevation of human blood arsenic and mercury levels in the Midwestern population of the United States (U.S.) and to determine any geographical patterns and variation of arsenic and mercury that may exist in Michigan. 58,800 blood specimens along with associated demographic/geographic data from the contiguous United States were reviewed. Univariate and multivariable logistic regression were used to analyze demographic/geographic variables associated with elevated arsenic concentrations. Furthermore, blood data from patients in Michigan were aggregated to the ZIP code tabulation area (ZCTA) in order to assess geographic variation using spatial regression models. SaTScan software was also used to analyze potential clustering of arsenic and mercury across Michigan ZCTAs. Within the contiguous United States, elevated mercury blood concentrations, older age, female sex, and coastal status were all associated with elevated arsenic blood concentrations (elevated mercury odds ratio (OR) 3.18 (3.04–3.33); female sex OR 1.06 (1.02–1.11); +10 yr age OR 1.12 (1.11–1.14); coastal state OR 1.33 (1.27–1.40). Within the state of Michigan, as with the continuous U.S., elevated mercury blood concentrations and older age were associated with elevated arsenic blood concentrations (elevated mercury OR 2.75 (2.38–3.18); female sex OR 1.06 (0.95–1.19); +10 yr age OR 1.10 (1.06–1.13). Using spatial regression, it was determined that within Michigan, economic inequality (measured via the Gini coefficient) was also associated with elevated concentrations of mercury in the blood. Clinical reference laboratory data, in conjunction with spatial analysis methods, may enhance our understanding of how elemental exposure affects human health and should be considered for studying how environmental contaminants, socioeconomics and geography affect the health of populations.

Short-chain chlorinated paraffins (SCCPs) were added to the Stockholm Convention on Persistent Organic Pollutants (POPs) at the eighth meeting of the conference of the parties in 2017. As a consequence, increasing environmental attention and international regulation on SCCPs is expected in the future. Inhalation uptake of particulate matter (PM) was an important exposure pathway for POPs into the human body. In the present study, a total of eighty PM2.5 samples were collected in the four seasons of the year at an urban site (Shandong University, Jinan) in Shandong province to investigate the seasonal changes of SCCPs and their inhalation exposure risks to human health. The concentrations of SCCPs ranged from 9.80 to 105 ng m−3, with the mean value of 38.7 ng m−3. The highest concentrations of SCCPs were detected in winter, while the lowest concentrations were in summer. SCCPs concentrations were positively correlated with the mass concentrations of PM2.5 (r = 0.629, p < 0.01), and negatively correlated with the ambient temperature (r = −0.447, p < 0.01). The SCCPs congeners with 10 carbon atoms (C10 congeners) and 7 chlorine numbers (Cl7 congeners) were the predominant congeners, which contributed 35% and 37% of the total SCCPs contamination, respectively. The average inhalation exposure was estimated to be 1.75 × 10−4 mg kg−1 day−1 for adults, which is much lower than the “no observed adverse effect level” (NOAEL) of 100 mg kg−1 day−1 given by European risk assessment for SCCPs.

Over the last decades, plastic debris has been identified and quantified in the marine environment. Coastal and riverine input have been recognized as sources of plastic debris, whereas oceanic gyres and sediments are understood to be sinks. However, we have a limited understanding of the fate of plastic debris in the nearshore environment. To investigate the movement and distribution of plastic debris in the nearshore environment, we collected samples at three distinct locations: below the high tide line, the turbulent zone created by the combination of breaking wave and backflush (defined as the boundary), and the outer nearshore. We estimated the abundance and physical characteristics (e.g. density, hardness, etc.) of macroplastic and microplastics. Four times and 15 times more macroplastics and microplastics are observed, respectively, at the boundary than in the outer nearshore waters, which suggests an accumulation driven by the physical properties of the plastic particles such as density, buoyancy and surface area. We further report that highly energetic conditions characteristic of the boundary area promote the long-term suspension and/or degradation of low density, highly buoyant or large surface area plastic debris, leading to their preferential accumulation at the boundary. Contrastingly, denser and low surface area plastic pieces were transported to the outer nearshore. These results emphasize the role of selective plastic movement at the nearshore driven by physical properties, but also by the combined effects of several hydrodynamics forces like wave action, wind or tide in the resuspension, as well as degradation and transport of plastic debris out of the nearshore environment.

Birnessites are abundant naturally occurring minerals with high sorption and oxidation capacity that could therefore play an important role in antimony (Sb) migration and transformation. There are various types of birnessites in the environment. However, little is known about the similarities and differences in Sb oxidation and sorption on birnessites with different properties. In this study, the behavior of Sb oxidation and sorption on two contrasting birnessites (δ-MnO₂ and triclinic birnessite (TrBir)) were investigated via batch and kinetic experiments and various spectroscopic techniques. Our results showed that the reaction mechanisms between Sb and the two birnessites were similar. The edge sites of birnessites were responsible for Sb(III) oxidation. Mn(IV) was reduced to Mn(III) and Mn(II), bound with birnessites and released to the solution, respectively. Because of the rapid rate of electron transfer of adsorbed Sb(III) to birnessites, the only Sb species on δ-MnO₂ after the oxidation reaction was Sb(V). Sb(V) was adsorbed at the edge sites of birnessites by replacing the OH group of birnessites, forming corner-sharing complexes with birnessites. However, the Sb sorption and oxidation capacities of the two birnessites were significantly different. Poorly-crystallized δ-MnO₂ exhibited a much higher oxidation and sorption capacity than well-crystallized TrBir because the former had many more edge sites than the latter. This study reveals the general mechanism of the reaction between Sb and birnessite and indicates that birnessite with a high number of edge sites would exhibit a huge capacity in Sb oxidation and sorption.

Many cities fail to meet air quality standards, which results in increased risk for pulmonary disorders, including asthma. Human and experimental studies have shown that diesel exhaust (DE) particles are associated with worsening of allergic asthma. Biodiesel (BD), a cleaner fuel from renewable sources, was introduced in the eighties. Because of the reduction in particulate matter (PM) emissions, BD was expected to cause fewer adverse pulmonary effects. However, only limited data on the effect of BD emissions in asthma are available.Determine whether BD exhaust exposure in allergic sensitized mice leads to different effects on inflammatory and functional responses compared to DE exposure.Balb/C mice were orotracheally sensitized with House Dust Mite (HDM) or a saline solution with 3 weekly instillations. From day 9 until day 17 after sensitization, they were exposed daily to filtered air (FA), DE and BD exhaust (concentration: 600 μg/m³ PM₂.₅). Lung function, bronchoalveolar lavage fluid (BALF) cell counts, cytokine levels (IL-2, IL-4, IL-5, IL-17, TNF-α, TSLP) in the BALF, peribronchiolar eosinophils and parenchymal macrophages were measured.HDM-sensitized animals presented increased lung elastance (p = 0.046), IgG1 serum levels (p = 0.029), peribronchiolar eosinophils (p = 0.028), BALF levels of total cells (p = 0.020), eosinophils (p = 0.028), IL-5 levels (p = 0.002) and TSLP levels (p = 0.046) in BALF. DE exposure alone increased lung elastance (p = 0.000) and BALF IL-4 levels (p = 0.045), whereas BD exposure alone increased BALF TSLP levels (p = 0.004). BD exposure did not influence any parameters after HDM challenge, while DE exposed animals presented increased BALF levels of total cells (p = 0.019), lymphocytes (p = 0.000), neutrophils (p = 0.040), macrophages (p = 0.034), BALF IL-4 levels (p = 0.028), and macrophagic inflammation in the lung tissue (p = 0.037), as well as decreased IgG1 (p = 0.046) and IgG2 (p = 0.043) levels when compared to the HDM group.The results indicate more adverse pulmonary effects of DE compared to BD exposure in allergic sensitized animals.

In order to accurately monitor the changes in a freshwater ecosystem in response to anthropogenic stressors, microbe–environment correlations and microbe–microbe interactions were combined to determine crucial indicator taxa in contaminated sediments. The diversity, composition, and co–occurrence pattern of bacterial communities in 23 sediment samples collected from Lake Taihu were explored using 16S rRNA amplicon sequencing analysis. Fisher's exact test showed that the cluster analyses of samples could show a direct correlation between the relative abundance of bacterial communities and the physicochemical properties of the sediment (P < 0.0001), suggesting that bacterial communities can be used to monitor contamination gradients in freshwater sediments. According to the microbe–environment correlation, 24 orders and 60 families were initially identified via indicator species analysis as indicator taxa of different pollution levels. The co–occurrence network further showed that topological features of bacterial communities were clearly different at different pollution levels, although the diversity and composition of bacterial communities displayed similarities between minimally and moderately polluted sites. Indicator taxa were then screened for keystone species, which co–occurrence relationships showed the high degree and low betweenness centrality values (i.e. degree >5, betweenness centrality <1000) of the network. Nine orders and 13 families were finally extracted as crucial indicator taxa of the different pollution levels in eutrophic Lake Taihu. Obtaining crucial indicator taxa from environmental sequences allows to trace increasing levels of pollution in aquatic ecosystems and provides a novel mean to monitor watersheds sensitive to anthropic influences.

Selenium (Se) is a metalloid of potential interest from both a toxicological and nutritional perspective, having a range of safe intake. The adverse neuro-behavioural effects of Se have been investigated in both humans and fishes, but little is known about its effects on social behaviours or the serotonergic signaling pathway in the brain. In the present study, we investigated the effects of chorionic dietary exposure to Se (as selenomethionine) at different concentrations (control, 2.1, 11.6 or 31.5 μg/g dry wt.) on antipredator avoidance, shoaling behaviour, and social group preferences in adult zebrafish (Danio rerio). In addition, we also measured the expression of important genes in the serotonergic pathway that influence social behaviours. After 60 days of exposure, the highest dose (31.5 μg/g dry wt.) caused the highest level of baseline fear behaviour, with fish swimming lower in the water column and in tighter shoals compared to fish in the other treatments. With high levels of baseline fear, these fish did not significantly intensify fear behaviours in response to predation risk in the form of exposure to chemical alarm cues. When individual fish were given an opportunity to shoal with groups of differing sizes (3 vs. 4 individuals), fish exposed to the high dose spent less time with groups in general, and only control fish showed a significant preference for the larger group. In the zebrafish brain, we found significant upregulation in the mRNA expression of serotonin receptors (htr1aa and htr1b), a transporter (slc6a4a), and tryptophan hydroxylase-2 (tph2), whereas there was a downregulation of the monoamine oxidase (mao) gene. The results of this study suggest that disruption of serotonergic neurotransmission might have been responsible for Se-induced impairment of antipredator and social behaviour in zebrafish.

Corals are exposed to organic ultraviolet (UV) filters and other personal care product (PCP) ingredients in the environment, but the toxicities of organic UV filters and their related PCP to corals are not well understood. In this study, 7-day exposures were conducted to evaluate the toxicities and bioaccumulation of two organic UV filters, ethylhexylmethoxy-cinnamate (EHMC; octinoxate) and octocrylene (OC) (single- and combined-chemical tests), and diluted sunscreen wash-off water containing both active ingredients to the adult life stage of two hard coral species, Seriatopora caliendrum and Pocillopora damicornis. In the single-chemical tests, death (33.3%) and bleaching (83.3%) were only observed in the 1000 μg/L EHMC treatment of S. caliendrum. In the sunscreen product exposures, 5% sunscreen water (containing 422.34 ± 37.34 μg/L of EHMC and 33.50 ± 7.60 μg/L of OC at Day 0) caused high mortality in S. caliendrum (66.7–83.3%) and P. damicornis (33.3–50%), and tissue concentrations were up to 10 times greater than in the single-chemical exposures; co-exposure to EHMC and OC at similar levels to those in the sunscreen product resulted in bioaccumulation similar to the single-chemical tests. These results confirm the bioaccumulation potential of EHMC and OC and show that other ingredients in sunscreen products may increase the bioavailability of active ingredients to corals and exacerbate the toxicity of sunscreen products. Future studies on the toxicities of PCPs to aquatic organisms should not only focus on the toxicities of active ingredients.

Microplastics are emerging contaminants in the marine environment. They enter the ocean in a variety of sizes and shapes, with plastic microfiber being the prevalent form in seawater and in the guts of biota. Most of the laboratory experiments on microplastics has been performed with spheres, so knowledge on the interactions of microfibers and marine organisms is limited. In this study we examined the ingestion of microfibers by the sea anemone Aiptasia pallida using three different types of polymers: nylon, polyester and polypropylene. The polymers were offered to both symbiotic (with algal symbionts) and bleached (without algal symbionts) anemones. The polymers were introduced either alone or mixed with brine shrimp homogenate. We observed a higher percentage of nylon ingestion compared to the other polymers when plastic was offered in the absence of shrimp. In contrast, we observed over 80% of the anemones taking up all types of polymers when the plastics were offered in the presence of shrimp. Retention time differed significantly between symbiotic and bleached anemones with faster egestion in symbiotic anemones. Our results suggest that ingestion of microfibers by sea anemones is dependent both on the type of polymers and on the presence of chemical cues of prey in seawater. The decreased ability of bleached anemones to reject plastic microfiber indicates that the susceptibility of anthozoans to plastic pollution is exacerbated by previous exposure to other stressors. This is particularly concerning given that coral reef ecosystems are facing increases in the frequency and intensity of bleaching events due to ocean warming.