This article summarizes data of determining a therapeutic dose of a new immunocorrecting drug, dermatocytoglobulin, developed by the authors of this study. It has been established that this drug has a therapeutic immunocorrecting effect on allergic dermatitis. Subjects of the study cattle, horses, of Raimbek – Commercial Diary Farm, 56 dogs and 35 cats admitted to a veterinary clinic. It has been established that administration of dermatocytoglobulin in trial groups reduces autoantibody titers until their elimination on the 12th day, dose of 0.2 cm3 per 10 kg while autoantibody titers in control groups were identified on the 30th day.

High economic losses in agriculture can be caused by pig disease like Postweaning Multisystemic Wasting Syndrome (PMWS). Porcine circovirus-2 (PCV2) is the primary agent of PMWS. It is known that PMWS causes cellular and humoral immunity disorders, therefore it is considered a general immune deficiency disease in piglets. It is still unknown, why piglets with PMWS have severe loss of lymphocytes in lymphoid tissues and in the blood. Thus, the hypothesis of the study was that lymphocyte depletion occurs because of lymphocyte life-cycle delay in pigs infected by PCV2. The activity of cell life-cycle is attributed to protein Ki67. This protein is found in all active phases of the cell like interphase G1, S, G2 and mitoses. However, protein Ki67 is not observed at all in the cell’s “quiet” phase G0. The aim of our work was to investigate the lymph node cell proliferation activity of pigs infected by PCV2. In total, 42 pig carcasses were collected from 5 to 15 weeks old pigs with PMWS clinical manifestation. Lymph nodes were selected from each pig carcass for histological and immunohistochemical testing. We concluded that B lymphocyte population was reduced first in the lymph node with PCV2, but the number of T lymphocytes decreased later. PCV2 decreased B lymphocyte proliferation activity.

The aim of this study was to detect radiodensity of a medial coronoid process of elbow joints with a medial coronoid disease and normal elbow joints in dogs. The study includes 91 large and giant breed dogs at the age from 6 to 30 months. Medial coronoid disease was diagnosed in 65 dogs and 26 dogs had normal elbow joints. Computed tomography was performed with Philips MX – 16 CT scanner and imaging data analysis performed using Horos v.2.2.0 software. CT technical data included 140 kVp, 250 mAs, 1 second rotation time and 0.75 slice thickness. The density of a medial coronoid process (MCP) was measured by two unrelated measurement methods. The study describes Hounsfield unit values in different areas of MCP in normal elbow joints and in medial coronoid disease affected joints. In 91.8% cases, MCP subchondral sclerosis observed with MCP fragmentation or fissure. We conclude that both bone density measurement methods are suitable for veterinary diagnostic imaging and can be used to evaluate canine elbow joints.

Canine elbow dysplasia is an heritable orthopaedic disease which includes medial coronoid disease, osteochondritis dissecans and ununited anconeal process, as well as, elbow incongruity. Medial coronoid disease (MCD) is one of the most frequent parts of elbow dysplasia syndrome. The aim of the study was to describe medial coronoid process CT findings in dogs with thoracic limb lameness. In cases where there is suspicion of medial coronoid disease for dogs with lameness, an orthopaedic examination and CT were performed. CT examination was done with Philips MX-16 – slice CT scanner. The study represents data from a time frame between September 2014 and December 2015. Examinations were done at The Faculty of Veterinary Medicine, Latvia University of Agriculture. The study included 20 large breed dogs, 14 males and 6 females, ages ranging from 6 to 60 months, with a median age of 21.7 ± 13.7 months. Results showed that, in most cases, the dogs had subtrochlear sclerosis of the ulna and fragmentation of medial coronoid. Computed tomography revealed 12 dogs with medial coronoid disease in both elbows, whereas 8 dogs only in one of the elbow joints.

The present work aimed to evaluate the effect of sea buckthorn (Hippophae rhamnoides) extract on Cryptosporidium spp. invasion in calves. Sea buckthorn is a good source of vitamins, carotenoids, organic acids and tannins. It has been reported that it possesses anti-inflammatory effect, as well as anthelmintic and antibacterial activity. Research was conducted in a dairy cattle farm ‘Mežacīruļi’ during April and July 2015. Experimental (n = 10) and control (n = 10) groups of calves were used. The experimental group received a mix of aqueous alcohol sea buckthorn leaf and berry pomace extract, administered with milk, at dose of 5 – 8 mL twice a day for 20 days. The control group received only milk. Samples were analysed with the concentration McMaster technique. The results showed that there is no significant (p is greater than 0.05) difference in the number of oocysts per gram of faeces between the experimental and control groups. It was concluded that the administration of sea buckthorn leaf and berry pomace extract had no effect on Cryptosporidium spp. invasion in calves. Studies will be continued with a higher dose of extract.

Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. Animal clinical studies suggest that PRP is a promising treatment for cartilage injuries and relieving symptoms due to its three biological properties: an anabolic effect, enhancement of cartilage regeneration and inhibition of inflammation. The aim of this article is to analyse the available evidence on the clinical application of this biological approach to animals for the injective treatment of cartilage lesions and joint degeneration, and also to support the rationale for the use of platelet concentrates and to give indications on what to expect from intra-articular injections of platelet-rich plasma (PRP) in animals. This article is a summary of analytical research papers about the use of platelet-rich plasma as a treatment for the osteoarthritis. The intra-articular injections do not just target cartilage; instead, platelet-rich plasma might influence the entire joint environment, leading to clinical improvement. Many biological variables might influence the clinical outcome and have to be studied to optimize PRP injective treatment of cartilage degeneration and osteoarthritis.

The aim of research was to analyse the spread of goats eimeriosis in Latvia, determine the structure of eimeria species as well as the efficiency of treatment of goats eimeriosis. Coprological examination of goats, carried out with Fileborn method, showed that the average level of eimeriosis influence on goats was about 25.2% and 3 dominant species of emeria such as E.arloingi, E.ninakohlyakimovae and E.alijevi. The highest level of influence was discovered to animals under 1 year of age, as with E.ninakohlyakimovae (62.5%) as the dominant specie, to animal above 1 year of age - E.arloingi (57.3%-66.7%), respectively. As the result, such preparations as sulfadimetoxine in dosage 75 mg kg*[-1) amprolsol 50 mg kg*[-1) showed high level (about 91%) of efficiency of emeriosis treatment.