The purpose of this study was to investigate and analyze the logistics spatial structure changes and to explain the objective factors affecting it in the Tehran metropolitan region during the period 1986-2011. The research method was descriptive-analytical, and in order to achieve the objectives of the research, three analytical methods – including indicators of number changes, growth rate, as well as the relative rate of changes in population density – employed in the logistics sector of each geographical area were used. On the other hand, analytical methods for measuring the degree of spatial concentration such as Gini coefficient and spatial autocorrelation as well as multiple regression analysis were used to estimate the correlation of effective factors with the spatial distribution of the employees working in the logistics sector (as the independent variable). The results of the analysis show that from 1986 to 2011, the spatial pattern of the logistics geographical distribution in the Tehran metropolitan region was centralized, consisting of the logistics cluster of Tehran metropolis. That is to say, tracking the process of spatial changes showed the decentralization of the population working in the logistics sector of Tehran metropolis and the concentration of this working population in the western and southwestern geographical areas surrounding the metropolis. From 1986 to 1996, among the objective factors affecting the logistics spatial patterns of metropolitan areas, the spatial distribution of the population working in the logistics sector had a higher correlation with the spatial distribution of population and labor force. That is to say, the higher the number and density of population and labor force in the geographical area, the higher the population working in the logistics sector. However, from 2006 to 2011, the spatial distribution of the population working in the logistics sector had a higher correlation with the spatial distribution of the population and the literacy rate.