Residential and employment attractions urge the population to reside in regions with appropriate potentials for development. The metropolitan regions of Iran have been attractive centers for the population; this attractiveness resulted in some changes in different spatial patterns. The present research examines the effect of spatial-physical, and demographic variables on metropolitan regions of Iran in order to achieve suitable planning for future spatial development of Iran. The objective of the study is to analyze correlation, centralization, and uniformity of distribution and composition of spatial patterns of development in the metropolitan regions. To do this, Shannon entropy, spatial Gini coefficient, spatial density index, and Kriging Estimator were employed. The results showed a trend that dictates on a decrease in concentration in metropolitan regions, which has manifested in different spatial patterns. In Tehran metropolitan region, the trend of development goes into polycentric with sprawl in the peri-urban and rural area. According to the development trend of population centers in Tehran, it can be said that at the same time of concentrated centralization, other settlements have played an effective role in the spatial structure of this metropolitan area, and strong road network has led to the formation of such pattern.  In Isfahan metropolitan region, the spatial structure has changed into concentration. This has happened with an unbalanced distribution to a radial pattern. While Mashhad metropolitan region has a monocentric linear pattern, Shiraz shows a monocentric and sprawl in the periphery. This can be attributed to the small growth of settlements compared to the metropolis.