Ports in most parts of the world play a great role in creating integrity between the prosperous of the regions and balancing the supply chain (production, distribution, and consumption). This article is to analyze the spatial interaction between the southern ports of Iran and local-regional hinterlands and explain the role of ports in shaping the spatial structure. For this purpose, a network analysis of commodity flows method is used in 1996, 2006 and 2015. The findings indicate that southern Iran's ports are often the importer of consumer goods in the populated centers, located in regional hinterlands, and, at best, have exported energy sources and raw materials. While urban centers, located in local hinterlands, do not play an effective role in the production and delivery of goods to ports, they are often dependent on the regional center (Shiraz) to meet their consumption needs. It revealed that although the process of spatial inequality has been moving towards greater balance over the past two decades, the development of medium-sized ports and local nodes in the contiguous hinterlands and forelands has led to a balanced monocentric spatial structure in this region.