This study was conducted to examine the soil fertility of the Büyük Menderes Basin, where wheat is widely cultivated. Soil samples were taken from 50 different points at a depth of 0-30 cm and various physical and chemical properties and amounts of nutrient elements were determined. With regard to the results of the study, the soils were generally sandy-clay-loam in texture, with slightly alkaline reaction, limy, rich in organic matter and showed no risk of salinity. The examined soils were found to be insufficient as 34% for total N, 14% for available K, 26% Mg, 10% Fe, 94% Zn and 98% Mn contents while all of the soils were determined as sufficient in terms of available P, Cu and Ca contents. When relationships between nutrient elements and soil physical-chemical properties were examined, negative correlations were found between soil pH and EC, organic matter, total N, available K, Zn; lime contents and available Mg, Fe, Cu; clay and available K and Mn contents. The positive correlations were found between EC and available K, Ca and Zn; organic matter % and total N, available K, Cu, Zn and Mn; sand % and available Mn; clay % and available Fe contents. Investigation of relationships between plant nutrients demonstrated that, there were positive correlations between total N and available K, Cu, Zn, Mn; available P and Zn; available K and Cu, Zn, Mn; available Ca and Fe; available Mg and Fe, Cu; available Fe and Cu, Mn; available Cu and Mn contents. The results of the study showed that attention should be paid to fertilization programs to fertilization with Zn and Mn, which were found to be insufficient in the greater part of the basin’s soils, and also to nitrogen deficiency is observed, as this directly affects the protein content of wheat.