Weeds pose a significant challenge in maize fields in the Dang district, leading to a substantial 52% reduction in yield. Hence, this study was conducted in Satbariya village of Dang, Nepal, in 2023 to evaluate the impact of various weed management practices on weed dynamics, growth, and yield of spring maize. The experiment included seven treatments: a weedy check, weed-free plot, pre-emergence application of atrazine at 1.25 a.i. kg/ha (AtPrE), post-emergence application of atrazine at 1.25 a.i. kg/ha (AtPoE), manual weeding at 30 DAS, mini-tiller at 30 DAS, and LaPoE (tembotrione 42% SC + atrazine 50% WP) applied as post-emergence. The Subarna variety of maize was chosen for the study. Fifteen weed species from seven different families were identified in the experimental area. Specific morphological and phenological parameters, such as plant height and days to tasseling and silking, were not significantly influenced by the weed control methods. However, significantly lower weed density and biomass were observed in the weed-free plot and LaPoE. Similarly, weed-free plots and LaPoE exhibited significantly higher weed control efficiency (WCE) and weed control index at both 45 and 60 DAS, leading to a lower weed index (0.00–16.71%) and more effective weed control. Concerning the yield parameters, cob length, number of kernels per row, and 1000-grain weight were significantly higher in weed-free plots, followed by LaPOE, and the highest grain and biological yield were observed in weed-free plot (6.14–15.18 tons/ha) and LaPoE (5.12–13.32 tons/ha). Moreover, the benefit-cost ratio and net return were observed to be highest with LaPoE. This study suggests that LaPoE can be an effective and economical weed management strategy for increasing maize yield and profitability. Further research could explore the long-term effects of using LaPoE on weed control and crop productivity.