There is limited focus on the water-energy-food (WEF) nexus approach at the local scale, particularly considering the social contexts of neglected territories. To contribute to this debate, we propose a framework to address this topic in an area in Angra dos Reis, Rio de Janeiro State, Brazil, as a case study. A survey was conducted regarding residents' perceptions, choices, practices and access to water, energy, and food. The interviews highlighted important topics on the WEF nexus. As a result, a set of 12 indicators with data available on official datasets was proposed, reflecting residents' perceptions of WEF safety. For each indicator, thresholds were established based mainly on the goals defined by Brazilian policies across different spheres-federal, state, or municipal. Thus, each indicator is multi-scale and integrative, since it comprises a local perspective (from the interview results), an official perspective (from the official databases), and a threshold. The results showed problems with energy and water supply, and the presence of home cropping, contrasting with residents who do not have access to basic food and experience extreme poverty. All these elements drew attention to the possibility of applying the WEF nexus approach, searching for feasible solutions which can support better decisions and governance in neglected territories.